Z. Hong Zhou

TL;DR: By employing manual molecular modeling programs such as Coot, Phenix, and Chimera, a cohesive methodology for de novo modeling with and without homology models is provided, which may serve as a starting point for other undergraduates and researchers just entering the realm of cryoEM.

TL;DR: In this paper, the authors presented five high-resolution cryoEM structures of group B coxsackievirus (CVB) representing different stages of virus infection, and showed that the CAR penetrates deeper into the canyon than other uncoating receptors, leading to a cascade of events: collapse of the VP1 hydrophobic pocket, high-efficiency release of the pocket factor and viral uncoaking and genome release under neutral pH, as compared with low pH.

TL;DR: The assembly principle and the ligand-gating mechanism of GABAA receptors containing both α and β subunits are elucidated, and the cryo-EM density map reveals that five wellresolved subunits form a cylinder-shaped central ion channel in a pseudo-symmetrical arrangement.

TL;DR: Fits to solution-phase small-angle X-ray scattering data using a Dammin bead model support the hypothesis of a bridging connection between PFT micelles, even in dilute aqueous solutions.

TL;DR: Near-atomic-resolution structures of the EBV capsid with an asymmetrically attached DNA-translocating portal and capsid-associated tegument complexes are determined from cryogenic electron microscopy images of just 2,048 EBV virions obtained by chemical induction.