Z
Z. Hong Zhou
Researcher at University of California, Los Angeles
Publications - 251
Citations - 13342
Z. Hong Zhou is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Capsid & Biology. The author has an hindex of 58, co-authored 225 publications receiving 11143 citations. Previous affiliations of Z. Hong Zhou include University of Texas Health Science Center at Houston & University of Science and Technology of China.
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Journal ArticleDOI
Visualizing Large RNA Molecules in Solution
TL;DR: The attached figure uses experimental and computational visualization methods to demonstrate that a 2774-nucleotide viral RNA has an elongated concave shape under in vitro assembly conditions and is physically slightly larger than the virus particle it ultimately packages into.
Journal ArticleDOI
Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses.
Ziyue Karen Jiang,Sok Boon S. Koh,Makoto Sato,Ivo Atanasov,Mai Johnson,Z. Hong Zhou,Timothy J. Deming,Lily Wu +7 more
TL;DR: The non-covalent modification was able to alter Ad's interactions with cells and organs with retention of transduction efficiency, and was potentially useful as a platform for adding functionalities to Ad to target cancer metastasis.
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The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses
Arvind Sharma,Xiaokang Zhang,Xiaokang Zhang,Wanwisa Dejnirattisai,Xinghong Dai,Danyang Gong,Wiyada Wongwiwat,Stéphane Duquerroy,Stéphane Duquerroy,Alexander Rouvinski,Marie-Christine Vaney,Pablo Guardado-Calvo,Ahmed Haouz,Patrick England,Ren Sun,Z. Hong Zhou,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Félix A. Rey +19 more
TL;DR: In this paper, the human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1-DENV4) and showed that C10 interaction with the latter viruses requires an E protein conformational landscape that limits binding to only one of the three independent epitopes per virion.
Journal ArticleDOI
Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity.
TL;DR: Cryo-electron tomography is employed to visualize synaptic ultrastructure in cultured hippocampal neurons and changes in subcellular features in response to chronic inactivity are investigated, consistent with a role for presynaptic DCVs in activity-dependent synapse maturation.
RAPID COMMUNICATION Three-Dimensional Visualization of Tegument/Capsid Interactions in the Intact Human Cytomegalovirus
TL;DR: The three-dimensional structure of the intact human cytomegalovirus (HCMV) was determined to 18-A resolution by electron cryomicroscopy and computer reconstruction as discussed by the authors.