Zaining Wu

TL;DR: It is found that virulence factors that are required for the initiation of acute infections are often selected against during chronic infections, including cystic fibrosis patient's P. aeruginosa strains.

TL;DR: These two genome sequences provide a platform for intra- and interspecies genomic comparisons in the genus Methylobacterium, and for investigations of the adaptive mechanisms which allow bacterial lineages to acquire methylotrophic lifestyles.

TL;DR: An Australian origin for B. pseudomallei is described, characterized by a single introduction event into Southeast Asia during a recent glacial period, and variable levels of lateral gene transfer within populations, to provide a framework for integrating the traditionally separate fields of population genetics and phylogenetics for other bacterial species with high levels ofateral gene transfer.

TL;DR: The genome of the strain responsible for HUS was sequenced and seven putative virulence determinants were identified, including two putative type III secretion system effector proteins, candidate genes that could result in increased pathogenicity or, alternatively, adaptation to plants, and an intact anaerobic nitric oxide reductase gene, norV.

TL;DR: Comparisons of whole-genome comparisons of clonal primary and relapse B. pseudomallei isolates recovered from four adult Thai patients provide new insights into pathogen evolution during long-term infections and have important implications for the development of intervention strategies to combat recurrent melioidosis.