Z
Zeynep Şıklar
Researcher at Ankara University
Publications - 159
Citations - 1811
Zeynep Şıklar is an academic researcher from Ankara University. The author has contributed to research in topics: Medicine & Short stature. The author has an hindex of 22, co-authored 143 publications receiving 1500 citations. Previous affiliations of Zeynep Şıklar include Turkish Ministry of Health.
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Journal ArticleDOI
Vitamin D Deficiency in Turkish Mothers and Their Neonates and in Women of Reproductive Age
Ayça Törel Ergür,Merih Berberoğlu,Begüm Atasay,Zeynep Şıklar,Pelin Bilir,Saadet Arsan,Feride Söylemez,Gönül Öcal +7 more
TL;DR: The study has shown that in Turkey VDD is an important problem in women of reproductive age, in mothers and their neonates, and the 25(OH)D levels obtained from the cord may serve as a guide in the determination of the high risk groups.
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Next-Generation Sequencing Reveals Deep Intronic Cryptic ABCC8 and HADH Splicing Founder Mutations Causing Hyperinsulinism by Pseudoexon Activation
Sarah E. Flanagan,Weijia Xie,Richard Caswell,Annet Damhuis,Christine Vianey-Saban,Teoman Akcay,Feyza Darendeliler,Firdevs Bas,Ayla Güven,Zeynep Şıklar,Gönül Öcal,Merih Berberoğlu,Nuala Murphy,Maureen J. O'Sullivan,Maureen J. O'Sullivan,Andrew Green,Andrew Green,Peter E. Clayton,Indraneel Banerjee,Indraneel Banerjee,Peter Clayton,Khalid Hussain,Khalid Hussain,Michael N. Weedon,Sian Ellard,Sian Ellard +25 more
TL;DR: This study investigated individuals with hyperinsulinaemic hypoglycaemia and biochemical or genetic evidence to suggest noncoding mutations by using NGS to analyze the entire genomic regions of ABCC8 and HADH from overlapping ~10 kb PCR amplicons, and identified two deep intronic mutations.
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Adherence to Growth Hormone Therapy: Results of a Multicenter Study
Banu Kucukemre Aydin,Zehra Aycan,Zeynep Şıklar,Merih Berberoğlu,Gönül Öcal,Semra Çetinkaya,Veysel Nijat Baş,Havva Nur Peltek Kendirci,Ergun Cetinkaya,Şükran Darcan,Damla Gökşen,Olcay Evliyaoğlu,Olcay Evliyaoğlu,Mine Sukur,Firdevs Bas,Feyza Darendeliler +15 more
TL;DR: Poor adherence to GH therapy was common in patients and was one of the factors underlying suboptimal growth during therapy and clinicians should confirm good adherence to therapy.
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Multiple Presentations of LRBA Deficiency: a Single-Center Experience
Sevgi Köstel Bal,Sule Haskologlu,Nina K. Serwas,Candan Islamoglu,Caner Aytekin,Tanıl Kendirli,Zarife Kuloğlu,Gulsan Yavuz,Buket Dalgic,Zeynep Şıklar,Aydan Kansu,Arzu Ensari,Kaan Boztug,Figen Dogu,Aydan Ikinciogullari +14 more
TL;DR: LRBA defects should always be kept in mind as a differential diagnosis for patients with autoimmune disease affecting multiple organs, chronic diarrhea, and organomegalies, and early HSCT is a life-saving therapeutic strategy.
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Recessively Inherited Lrba Mutations Cause Autoimmunity Presenting as Neonatal Diabetes.
Matthew B. Johnson,Elisa De Franco,Hana Lango Allen,Aisha Al Senani,Nancy Samir Elbarbary,Zeynep Şıklar,Merih Berberoğlu,Z. Imane,Alireza Haghighi,Alireza Haghighi,Alireza Haghighi,Zahra Razavi,Irfan Ullah,Saif Al-Yaarubi,Daphne Gardner,Sian Ellard,Andrew T. Hattersley,Sarah E. Flanagan +17 more
TL;DR: LRBA testing should be considered in patients with diabetes diagnosed <12 months, particularly if they have additional autoimmunity or are born to consanguineous parents, as it can enable personalized therapy with abatacept, a CTLA-4 mimetic, and inform genetic counseling.