P
Patrick G. Shaw
Researcher at Johns Hopkins University
Publications - 13
Citations - 3709
Patrick G. Shaw is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Proteomics & Stable isotope labeling by amino acids in cell culture. The author has an hindex of 13, co-authored 13 publications receiving 3254 citations. Previous affiliations of Patrick G. Shaw include Johns Hopkins University School of Medicine & University of Pittsburgh.
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A draft map of the human proteome
Min-Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree S. Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,Bijesh George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Pavithra Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai-Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan K Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry H N Lam,Chris J. Mitchell,Susarla K. Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio-Donahue,Harsha Gowda,Akhilesh Pandey +73 more
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Journal ArticleDOI
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Aaron R. Haeusler,Christopher J. Donnelly,Goran Periz,Eric A J Simko,Patrick G. Shaw,Min-Sik Kim,Nicholas J. Maragakis,Juan C. Troncoso,Akhilesh Pandey,Rita Sattler,Jeffrey D. Rothstein,Jiou Wang +11 more
TL;DR: It is demonstrated that distinct C9orf72 HRE structural polymorphism at both DNA and RNA levels initiates molecular cascades leading to ALS/FTD pathologies, and provides the basis for a mechanistic model for repeat-associated neurodegenerative diseases.
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Plasma Proteome Database as a resource for proteomics research: 2014 update
Vishalakshi Nanjappa,Joji Kurian Thomas,Arivusudar Marimuthu,Babylakshmi Muthusamy,Aneesha Radhakrishnan,Rakesh Sharma,Aafaque Ahmad Khan,Lavanya Balakrishnan,Nandini A. Sahasrabuddhe,Satwant Kumar,Binit N Jhaveri,Kaushal V. Sheth,Ramesh Kumar Khatana,Patrick G. Shaw,S Srikanth,Premendu P. Mathur,Subramanian Shankar,Dindagur Nagaraja,Rita Christopher,Suresh Mathivanan,Rajesh Raju,Ravi Sirdeshmukh,Aditi Chatterjee,Richard J. Simpson,H. C. Harsha,Akhilesh Pandey,T. S. Keshava Prasad,T. S. Keshava Prasad +27 more
TL;DR: The latest version of the database also incorporates mass spectrometry-derived data including experimentally verified proteotypic peptides used for multiple reaction monitoring assays and a batch-based query designated Plasma Proteome Explorer, which will permit the users in screening a list of proteins or peptides against known plasma proteins to assess novelty of their data set.
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Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
Abena S. Agyeman,Raghothama Chaerkady,Patrick G. Shaw,Nancy E. Davidson,Kala Visvanathan,Akhilesh Pandey,Thomas W. Kensler,Thomas W. Kensler +7 more
TL;DR: Significant changes in transcriptomic and proteomic changes in the estrogen receptor negative, non-tumorigenic human breast epithelial MCF10A cell line were analyzed to identify potential biomarkers that can be used in clinical trials to investigate the initial pharmacodynamic action of SFN in the breast.
Journal ArticleDOI
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
TL;DR: This study suggests that LSD1 intimately interacts with histone deacetylases in human breast cancer cells, and may represent a promising and novel approach for epigenetic therapy of breast cancer.