Z
Zhihong Wu
Researcher at University of Kiel
Publications - 22
Citations - 1062
Zhihong Wu is an academic researcher from University of Kiel. The author has contributed to research in topics: Desquamation & KLK5. The author has an hindex of 12, co-authored 22 publications receiving 949 citations. Previous affiliations of Zhihong Wu include Zhejiang University of Science and Technology.
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Journal ArticleDOI
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1
Bjoern O. Schroeder,Zhihong Wu,Sabine Nuding,Sabine Nuding,Sandra Groscurth,Moritz Marcinowski,Julia Beisner,Julia Beisner,Johannes Buchner,Martin Schaller,Eduard F. Stange,Jan Wehkamp,Jan Wehkamp,Jan Wehkamp +13 more
TL;DR: Reduced hBD-1 shields the healthy epithelium against colonisation by commensal bacteria and opportunistic fungi and against anaerobic, Gram-positive commensals of Bifidobacterium and Lactobacillus species.
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Molecular Identification and Expression Analysis of Filaggrin-2, a Member of the S100 Fused-Type Protein Family
TL;DR: It is provided that like filaggrin, FLG2 is initially expressed by upper granular cells, proteolytically processed and deposited in the stratum granulosum and stratum corneum layers of normal epidermis, and may have overlapping and perhaps synergistic roles in the formation of the epidermal barrier.
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Isolation of SPINK6 in Human Skin SELECTIVE INHIBITOR OF KALLIKREIN-RELATED PEPTIDASES
Ulf Meyer-Hoffert,Zhihong Wu,Tomasz Kantyka,Jan A. Fischer,Ties Latendorf,Britta Hansmann,Joachim Bartels,Yinghong He,Regine Gläser,Jens-Michael Schröder +9 more
TL;DR: The findings suggest that SPINK6 plays a role in modulating the activity of KLKs in human skin and might have therapeutic potential when KLK activity is elevated.
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Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.
TL;DR: It is suggested that LEKTI-2 contributes to the regulation of the desquamation process in human skin by specifically inhibiting KLK5.
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Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide.
Kyaw Zaw Hein,Hitoshi Takahashi,Toshiko Tsumori,Toshiko Tsumori,Yukihiko Yasui,Yasuko Nanjoh,Tetsuo Toga,Zhihong Wu,Joachim Grötzinger,Sascha Jung,Jan Wehkamp,Jan Wehkamp,Bjoern O. Schroeder,Jens Schroeder,Eishin Morita +14 more
TL;DR: RedS100A7 inhibits various filamentous fungi, including the mold Aspergillus fumigatus, but not Candida albicans, and cell-penetrating Zn2+-chelator TPEN was found to function as a broad-spectrum antifungal.