Z
Zhihua Liu
Researcher at Chinese Academy of Sciences
Publications - 34
Citations - 4302
Zhihua Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Farnesyl Transferase Inhibitor & Paneth cell. The author has an hindex of 17, co-authored 32 publications receiving 3866 citations. Previous affiliations of Zhihua Liu include Brigham and Women's Hospital & National Institutes of Health.
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Journal ArticleDOI
Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu,Christina K. McPhee,Christina K. McPhee,Lixin Zheng,Gonzalo A. Mardones,Gonzalo A. Mardones,Yueguang Rong,Junya Peng,Na Mi,Ying Zhao,Zhihua Liu,Fengyi Wan,Dale W. Hailey,Viola Oorschot,Judith Klumperman,Eric H. Baehrecke,Michael J. Lenardo +16 more
TL;DR: It is shown that mTOR signalling in rat kidney cells is inhibited during initiation of autophagy, but reactivated by prolonged starvation, and this generates proto-lysosomal tubules and vesicles that extrude from autolysosomes and ultimately mature into functional lysosomes, thereby restoring the full complement of lysosity in the cell.
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The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility
TL;DR: In this article, a second, dimerization-dependent, ubiquityl ligase activity was found in the C-terminal hydrolase-L1 (UCHL1) enzyme.
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Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae
TL;DR: This paper provides the first global evidence that genes with similar expression profiles are more likely to encode interacting proteins, and shows how this correlation between transcriptome and interactome data can be used to improve the quality of hypotheses based on the information from both approaches.
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Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Xian Lin,Loukia Parisiadou,Xinglong Gu,Lizhen Wang,Hoon Shim,Lixin Sun,Chengsong Xie,Cai Xia Long,Wan Jou Yang,Jinhui Ding,Zsu Zsu Chen,Paul E. Gallant,Jung-Hwa Tao-Cheng,Juan C. Troncoso,Zhihua Liu,Zheng Li,Huaibin Cai +16 more
TL;DR: It is demonstrated that overexpression of LRRK2 enhances alpha-synuclein-mediated cytotoxicity and inhibition of L RRK2 expression is suggested as a potential therapeutic option for ameliorating alpha- synucleIn-induced neurodegeneration.
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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
TL;DR: A new step in the control of NFAT activation that involves an immunoregulatory function of LRRK2 is defined and has important implications for inflammatory bowel disease.