Z
Zhiping Qian
Researcher at Johns Hopkins University
Publications - 27
Citations - 734
Zhiping Qian is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Transplantation & Complement system. The author has an hindex of 14, co-authored 27 publications receiving 720 citations.
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Journal ArticleDOI
Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice.
Barbara A. Wasowska,Zhiping Qian,D. Cangello,E Behrens,Khanh Van Tran,Jodi Layton,Fred Sanfilippo,William M. Baldwin +7 more
TL;DR: A model of alloantibody-mediated graft injury is established using B10.A hearts transplanted to wild type or immunoglobulin knock out (IgKO) mice, indicating that macrophage- and T-cell-dependent immune responses were intact in IgKO recipients.
Journal ArticleDOI
Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts.
Salma Rahimi,Zhiping Qian,Jodi Layton,Karen Fox-Talbot,William M. Baldwin,Barbara A. Wasowska +5 more
TL;DR: Non‐complement‐activating AlloAbs stimulate endothelial cells to produce chemokines and this effect is augmented in the milieu of proinflammatory cytokines, indicating that non-complement •activating •AlloAbs can augment injury to allografts by complement‐activated Allo Abs.
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Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection
TL;DR: It is demonstrated that MAC causes vascular injury in lung allografts and that the location of injury is dependent on the source of C6, which is demonstrated at the mRNA and protein levels.
Journal ArticleDOI
Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants.
Kazunori Murata,Karen Fox-Talbot,Zhiping Qian,Kazue Takahashi,Gregory L. Stahl,William M. Baldwin,Barbara A. Wasowska +6 more
TL;DR: A novel role for non‐complement‐activating alloantibodies and MBL in humoral rejection is suggested, as demonstrated in mice reconstituted with monoclonal antibodies to MHC class I antigens.
Journal ArticleDOI
C6 produced by macrophages contributes to cardiac allograft rejection.
Zhiping Qian,Barbara A. Wasowska,E Behrens,D. Cangello,Jonathan R. Brody,Shri Hari S. Kadkol,Louis Horwitz,Jinhuan Liu,Charles J. Lowenstein,Allan D. Hess,Fred Sanfilippo,William M. Baldwin +11 more
TL;DR: Results indicate that C6 produced by macrophages can cause significant tissue damage in hearts grafted to hosts after C6 reconstitution by bone marrow transplantation.