Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts.
Salma Rahimi,Zhiping Qian,Jodi Layton,Karen Fox-Talbot,William M. Baldwin,Barbara A. Wasowska +5 more
TLDR
Non‐complement‐activating AlloAbs stimulate endothelial cells to produce chemokines and this effect is augmented in the milieu of proinflammatory cytokines, indicating that non-complement •activating •AlloAbs can augment injury to allografts by complement‐activated Allo Abs.About:
This article is published in American Journal of Transplantation.The article was published on 2004-03-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Complement system & Proinflammatory cytokine.read more
Citations
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Banff '09 meeting report: Antibody mediated graft deterioration and implementation of Banff working groups
Banu Sis,Michael Mengel,Mark Haas,Robert B. Colvin,Philip F. Halloran,Lorraine C. Racusen,Kim Solez,William M. Baldwin,Erika Bracamonte,V. Broecker,Fernando G. Cosio,Anthony J. Demetris,Cinthia B. Drachenberg,Gunilla Einecke,James M. Gloor,Denis Glotz,Edward S. Kraus,Christophe Legendre,Helen Liapis,Roslyn B. Mannon,Brian J. Nankivell,Volker Nickeleit,John C. Papadimitriou,Parmjeet Randhawa,Heinz Regele,Karine Renaudin,E. R. Rodriguez,Daniel Serón,Surya V. Seshan,Manikkam Suthanthiran,Barbara A. Wasowska,Andrea A. Zachary,A. Zeevi +32 more
TL;DR: The willingness of the Banff process to adapt continuously in response to new research and improve potential weaknesses, led to the implementation of six working groups on the following areas: isolated v‐lesion, fibrosis scoring, glomerular lesions, molecular pathology, polyomavirus nephropathy and quality assurance.
Journal ArticleDOI
Antibody-Mediated Renal Allograft Rejection: Diagnosis and Pathogenesis
TL;DR: Substantial practical experience by pathologists in the interpretation and pitfalls of C4d stains are reviewed along with considerations of the clinical significance and pathologic mechanisms of the different effects of antibody on the endothelium of the renal allograft.
Journal ArticleDOI
Antibody-mediated organ-allograft rejection
Robert B. Colvin,R. Neal Smith +1 more
TL;DR: Antibody induces rejection acutely through the fixation of complement, resulting in tissue injury and coagulation, and complement activation recruits macrophages and neutrophils, causing additional endothelial injury.
Journal ArticleDOI
De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival.
John D. Smith,Nicholas R. Banner,I. M. Hamour,Miyuki Ozawa,A. Goh,Derek R. Robinson,Paul I. Terasaki,Marlene L. Rose +7 more
TL;DR: Patients who are transplanted in the absence of pre‐existing DSA make de novo DSA after transplantation which are associated with poor survival, and early and regular monitoring of post‐transplant DSA is required to identify patients at risk of allograft failure.
Journal ArticleDOI
IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
Carmen Lefaucheur,Denis Viglietti,Carol Bentlejewski,Jean-Paul Duong Van Huyen,Dewi Vernerey,Olivier Aubert,Jérôme Verine,Xavier Jouven,Christophe Legendre,Denis Glotz,Alexandre Loupy,Adriana Zeevi +11 more
TL;DR: IgG iDSA subclasses identify distinct phenotypes of kidney allograft antibody-mediated injury as well as HLA class specificity, MFI level, C1q-binding status, and IgG subclasses in a Cox survival model are revealed.
References
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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
TL;DR: The importance of the membrane form of the μ chain in B-cell development is assessed by generating mice lacking this chain by disrupting one of the membranes exons of the gene encoding the μ-chain constant region by gene targeting in mouse embryonic stem cells.
Journal ArticleDOI
Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection.
Lorraine C. Racusen,Robert B. Colvin,Kim Solez,Michael J. Mihatsch,Philip F. Halloran,Patricia Campbell,Michael Cecka,Jean Pierre Cosyns,Anthony J. Demetris,Michael C. Fishbein,Agnes B. Fogo,Peter N. Furness,Ian W. Gibson,Denis Glotz,Pekka Häyry,Lawrence Hunsickern,Michael Kashgarian,Ronald H. Kerman,Alex J. Magil,Robert A. Montgomery,Kunio Morozumi,Volker Nickeleit,Parmjeet Randhawa,Heinz Regele,Daniel Serón,Surya V. Seshan,Stale Sund,Kiril Trpkov +27 more
TL;DR: This article presents international consensus criteria for and classification of AbAR developed based on discussions held at the Sixth Banff Conference on Allograft Pathology in 2001, to be revisited as additional data accumulate in this important area of renal transplantation.
Journal Article
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.
TL;DR: Strain distribution analyses so far indicate that the public specificities detected by these monoclonal antibodies are considerably different from those that had been established by traditional serology, which may have important implications relating to the structure and evolution of MHC gene products.
Journal ArticleDOI
Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications.
TL;DR: Receptors for the Fc domain of IgG (Fc gamma R) provide a critical link between specific humoral responses and the cellular branch of the immune system and, importantly, recent evidence points at the relevance of this Fc Gamma R heterogeneity.
Journal ArticleDOI
Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients
Robert A. Montgomery,Andrea A. Zachary,Lorraine C. Racusen,Mary S. Leffell,Karen E. King,James F. Burdick,Warren R. Maley,Lloyd E. Ratner +7 more
TL;DR: This protocol shows promise for eliminating DSA preemptively among patients with low-titer positive antihuman globulin-enhanced, complement-dependent cytotoxicity cross-matches, allowing the successful transplantation of these patients using a live donor without any cases of HAR.
Related Papers (5)
Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection.
Lorraine C. Racusen,Robert B. Colvin,Kim Solez,Michael J. Mihatsch,Philip F. Halloran,Patricia Campbell,Michael Cecka,Jean Pierre Cosyns,Anthony J. Demetris,Michael C. Fishbein,Agnes B. Fogo,Peter N. Furness,Ian W. Gibson,Denis Glotz,Pekka Häyry,Lawrence Hunsickern,Michael Kashgarian,Ronald H. Kerman,Alex J. Magil,Robert A. Montgomery,Kunio Morozumi,Volker Nickeleit,Parmjeet Randhawa,Heinz Regele,Daniel Serón,Surya V. Seshan,Stale Sund,Kiril Trpkov +27 more