Zhuo Deng

TL;DR: In this paper, the unfolded protein response transcription factor spliced X-box binding protein 1 (XBP1s) was shown to protect against diet-induced obesity as well as improve leptin and insulin sensitivity.

TL;DR: It is found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue.

TL;DR: This work shows that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure and increase food intake resulting in elevated body weight and demonstrates that the Ht2Cr agonist lorcaserin-induced improvements in glucose and insulin tolerance are blocked by TrpC 5 deficiency in Pomc neurons.

TL;DR: It is found that pro-opiomelanocortin (Pomc)–specific deficiency of Ire1α accelerated diet-induced obesity concomitant with a decrease in energy expenditure as well as “beiging” of white adipose tissue.