Y
Yongsheng Chang
Researcher at Peking Union Medical College
Publications - 63
Citations - 2847
Yongsheng Chang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Insulin resistance & Gluconeogenesis. The author has an hindex of 24, co-authored 55 publications receiving 2383 citations. Previous affiliations of Yongsheng Chang include Tianjin Medical University.
Papers
More filters
Journal ArticleDOI
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
Xingxing Kong,Rui Wang,Yuan Xue,Xiaojun Liu,Huabing Zhang,Yong Chen,Fude Fang,Yongsheng Chang +7 more
TL;DR: It is shown that Sirt3 functions as a downstream target gene of PGC-1α and mediates the P GC-1 α effects on cellular ROS production and mitochondrial biogenesis, and integrates cellular energy metabolism and ROS generation.
Journal ArticleDOI
Overexpression of Micro Ribonucleic Acid 29, Highly Up-Regulated in Diabetic Rats, Leads to Insulin Resistance in 3T3-L1 Adipocytes
TL;DR: It is demonstrated that Akt is not the direct target gene of miR-29 and that the negative effects of mi R-29 on insulin signaling might be mediated by other unknown intermediates, and taken together, these data reveal the crucial role of MiRNAs in type 2 diabetes.
Journal ArticleDOI
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.
Kevin W. Williams,Tiemin Liu,Xingxing Kong,Makoto Fukuda,Makoto Fukuda,Yingfeng Deng,Eric D. Berglund,Zhuo Deng,Zhuo Deng,Yong Gao,Yong Gao,Tianya Liu,Tianya Liu,Jong Woo Sohn,Lin Jia,Teppei Fujikawa,Daisuke Kohno,Daisuke Kohno,Michael Scott,Syann Lee,Charlotte E. Lee,Kai Sun,Yongsheng Chang,Philipp E. Scherer,Joel K. Elmquist +24 more
TL;DR: In this paper, the unfolded protein response transcription factor spliced X-box binding protein 1 (XBP1s) was shown to protect against diet-induced obesity as well as improve leptin and insulin sensitivity.
Journal ArticleDOI
PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα
Di Shao,Yang Liu,Xiaojun Liu,Liu-luan Zhu,Ying Cui,Anfang Cui,Aijun Qiao,Xingxing Kong,Yong Liu,Quan Chen,Nishith Gupta,Fude Fang,Yongsheng Chang +12 more
TL;DR: This study reveals that P GC-1 beta is highly induced during myogenic differentiation and knockdown of endogenous PGC-1beta by siRNA leads to a decrease in the expression of several mitochondria-related genes.
Journal ArticleDOI
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat
Lu Yao,Xiaona Cui,Qi Chen,Xiaoying Yang,Fude Fang,Jun Zhang,Guoqing Liu,Wanzhu Jin,Yongsheng Chang +8 more
TL;DR: A critical role for SIRT6 is revealed in regulating thermogenesis of fat and preventing browning of white adipose tissue following cold exposure or β3-agonist treatment.