Makoto Fukuda

TL;DR: It is shown that p110 is CRM1, which is an evolutionarily conserved protein originally found as an essential nuclear protein in fission yeast and known as a likely target of LMB, which indicates that CRM 1 is an essential mediator of the NES-dependent nuclear export of proteins in eukaryotic cells.

TL;DR: It is demonstrated that IRF‐3 transmits a virus‐induced signal from the cytoplasm to the nucleus, and it is suggested that IRf‐3 plays an important role in the virus‐inducible primary activation of type I IFN and IFN‐responsive genes.

TL;DR: It is shown that introduction of v‐Ras, active STE11 or constitutively active MAPKK can induce nuclear translocation of MAPK in mammalian cultured cells and evidence suggests that MAPK is localized to the cytoplasm through its specific association with MAPKK and that nuclear accumulation is accompanied by dissociation of a complex between MAPK and MAPKK following activation of the MAPK pathway.

TL;DR: It is concluded that direct action of insulin and leptin on POMC neurons is required to maintain normal glucose homeostasis and reproductive function.

TL;DR: It is shown that expression of the NES‐disrupted cyclin B1 or LMB treatment of the cells is able to override the DNA damage‐induced G2 checkpoint when combined with caffeine treatment, and this results suggest a role of nuclear exclusion ofCytoplasmic localization of cyclIn B1 during interphase is directed by its nuclear export signal (NES)‐dependent transport mechanism.