Zhuo-Xun Wu

TL;DR: The role of microbiota in health and diseases is highlighted by numerous studies since its discovery as mentioned in this paper , which can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc.

TL;DR: The reversal of the dual functions of ABC-transporter-mediated and AKT-activation-enhanced MDR through the inhibition or knockout of PI3K 110α or 110β promises to improve current strategies based on combined drug treatments to overcome MDR challenges.

TL;DR: The recent progress in overcoming cancer drug resistance is summarized in three novel aspects: mRNA modification, which includes alternative splicing, A-to-I modification and mRNA methylation, and posttranslational modification on molecules, which encompasses drug inactivation/efflux, drug target modifications, DNA damage repair, cell death resistance, EMT, and metastasis.

TL;DR: The applications and mechanisms of action of CQ and HCQ in their conventional fields of anti-malaria and anti-rheumatism, as well as their repurposing prospects in anti-virus are reviewed.

TL;DR: A potential chemotherapeutic strategy of co-administrating tepotinib with other conventional chemotherAPEutic agents to overcome MDR and improve therapeutic effect is provided.