Institution
Aichi Gakusen University
Education•Toyota, Japan•
About: Aichi Gakusen University is a education organization based out in Toyota, Japan. It is known for research contribution in the topics: Capillary electrophoresis & Derivatization. The organization has 93 authors who have published 106 publications receiving 1690 citations.
Papers published on a yearly basis
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Winterthur Museum, Garden and Library1, Agency for Science, Technology and Research2, University of Rochester3, University of Kentucky4, University of Birmingham5, University of Salzburg6, Tokyo University of Science7, Jichi Medical University8, National Institute for Environmental Studies9, Aichi Gakusen University10, National Taiwan University11, University of Plymouth12, University of the Witwatersrand13, Science and Technology Policy Institute14, Utrecht University15
TL;DR: Lessons learned from the past can prove helpful for the future of the field, notably for understanding novel particles and fibres and for defining appropriate risk management and governance approaches.
Abstract: Particles and fibres affect human health as a function of their properties such as chemical composition, size and shape but also depending on complex interactions in an organism that occur at various levels between particle uptake and target organ responses. While particulate pollution is one of the leading contributors to the global burden of disease, particles are also increasingly used for medical purposes. Over the past decades we have gained considerable experience in how particle properties and particle-bio interactions are linked to human health. This insight is useful for improved risk management in the case of unwanted health effects but also for developing novel medical therapies. The concepts that help us better understand particles’ and fibres’ risks include the fate of particles in the body; exposure, dosimetry and dose-metrics and the 5 Bs: bioavailability, biopersistence, bioprocessing, biomodification and bioclearance of (nano)particles. This includes the role of the biomolecule corona, immunity and systemic responses, non-specific effects in the lungs and other body parts, particle effects and the developing body, and the link from the natural environment to human health. The importance of these different concepts for the human health risk depends not only on the properties of the particles and fibres, but is also strongly influenced by production, use and disposal scenarios. Lessons learned from the past can prove helpful for the future of the field, notably for understanding novel particles and fibres and for defining appropriate risk management and governance approaches.
144 citations
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TL;DR: The results suggest that reactive oxygen species may attack the mitochondrial respiratory chain, leading eventually to the degeneration of vulnerable motor neurons in the spinal cord, even though no obvious changes in the activity of antioxidant enzymes are detectable.
Abstract: The cause of selective degeneration of motor neurons in the ventral horn of the spinal cord associated with amyotrophic lateral sclerosis (ALS) has still not been elucidated. Recently, so-called oxidative stress has been suggested to be a significant factor in the pathogenesis of this disease. We measured the antioxidant actions of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and cytochrome c oxidase (CO) of the human spinal cord in patients with ALS in comparison with those in control patients. Total SOD activity in spinal cord transections from patients with sporadic ALS was not significantly different from the controls in ventral, lateral, or dorsal regions, although enzymic activity was relatively higher in the ventral compared with the dorsal region. GSH-Px activity in the spinal cord of ALS patients was not very different from that in the control tissue. In contrast, CO activity was significantly reduced in all three regions of the spinal cord in patients with ALS, although the reduction was more marked in the ventral region. These results suggest that reactive oxygen species may attack the mitochondrial respiratory chain, leading eventually to the degeneration of vulnerable motor neurons in the spinal cord, even though no obvious changes in the activity of antioxidant enzymes are detectable. © 1996 Wiley-Liss, Inc.
141 citations
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TL;DR: Oral L-92 administration regulated both Th1 and Th2 cytokine responses, suppressed serum OVA-specific IgE, and induced TGF-beta production in PPs, suggesting that LAB may have immunomodulative effect by Treg cells via TGF -beta activity.
113 citations
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TL;DR: The reliability study indicated that the Pearson's correlation coefficients between two assessments of daily energy expenditure and weekly physical activity over one-year ranged from 0.37 to 0.62, indicating that the PA-questionnaire has adequate levels of validity and test-retest reliability in assessment of dailyEnergy expenditure andweekly physical activity in epidemiological studies.
106 citations
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TL;DR: In the case of young women, getting a good quality and quantity of sleep in normal life seems to be important for promoting their mental health, which may fluctuate throughout the menstruation cycle accompanied by mental symptoms as a part of premenstrual syndrome.
Abstract: The relationship of meal habits and alcohol/cigarette consumption to circadian typology and sleep health in Japanese female students was studied from an epidemiological point of view. Questionnaires on Morningness-Eveningness by Torsvall and Akerstedt (1980), sleep habits, regularity of meal intake and meal amount, and style of alcohol and cigarette consumption were administered to 800 students aged 18-29 years, attending university or training schools for nutrition specialists (Aichi Prefecture, 35 degrees N). Points from ten questions were totaled to provide estimates of sleep habits given as the Unhealthy Sleep Index (UHSI). The average and standard deviation of Morningness-Eveningness scores were 16.07+/-3.53. Students who had breakfast at regular times showed significantly higher Morningness-Eveningness scores than those who ate at irregular times. Based on an integrated analysis (ANOVA) on the effect of regularity of breakfast intake on sleep health, regular breakfast intake may link to sleep health positively via the shifting to morning-type (i.e., the phase-advance of the circadian clock). However, a similar analysis promoted the hypothesis that alcohol consumption and cigarette smoking relate to sleep health negatively and directly, rather than via the shifting to evening-type (i.e., the phase-delaying of the circadian clock). In the case of young women, getting a good quality and quantity of sleep in normal life seems to be important for promoting their mental health, which may fluctuate throughout the menstruation cycle accompanied by mental symptoms as a part of premenstrual syndrome.
89 citations
Authors
Showing all 93 results
Name | H-index | Papers | Citations |
---|---|---|---|
Koji Otsuka | 48 | 271 | 9485 |
Naomi Hisanaga | 29 | 106 | 2449 |
Shigeyuki Oguri | 15 | 24 | 591 |
Masato Ando | 11 | 19 | 424 |
Kiyoshi Shibata | 10 | 21 | 313 |
Tomono Uchida | 9 | 13 | 236 |
Hitomi Takemura | 8 | 13 | 439 |
Aki Konomi | 5 | 14 | 136 |
Kazuyo Horie | 5 | 7 | 205 |
Michie Moriyama | 4 | 9 | 78 |
Shinpei Torii | 4 | 5 | 165 |
Koichiro Iwamoto | 4 | 16 | 58 |
Hideki Sato | 4 | 29 | 65 |
Masamitsu Yamauchi | 3 | 3 | 22 |
Kimiko Sugase | 2 | 3 | 43 |