Bradford Royal Infirmary

About: Bradford Royal Infirmary is a healthcare organization based out in Bradford, United Kingdom. It is known for research contribution in the topics: Population & Pregnancy. The organization has 1630 authors who have published 1663 publications receiving 43774 citations.

An Analysis of Clostridium difficile Environmental Contamination During and After Treatment for C difficile Infection.

Abstract: Background Lower Clostridium difficile spore counts in feces from C difficile infection (CDI) patients treated with fidaxomicin versus vancomycin have been observed. We aimed to determine whether environmental contamination is lower in patients treated with fidaxomicin compared with those treated with vancomycin/metronidazole. Methods The CDI cases were recruited at 4 UK hospitals (Leeds, Bradford, and London [2 centers]). Environmental samples (5 room sites) were taken pretreatment and at 2-3, 4-5, 6-8, and 9-12 days of treatment, end of treatment (EOT), and post-EOT. Fecal samples were collected at diagnosis and as often as produced thereafter. Swabs/feces were cultured for C difficile; percentage of C difficile-positive samples and C difficile bioburden were compared between different treatment arms at each time point. Results Pre-EOT (n = 244), there was a significant reduction in environmental contamination (≥1 site positive) around fidaxomicin versus vancomycin/metronidazole recipients at days 4-5 (30% vs 50% recipients, P = .04) and at days 9-12 (22% vs 49%, P = .005). This trend was consistently seen at all other timepoints, but it was not statistically significant. No differences were seen between treatment groups post-EOT (n = 76). Fidaxomicin-associated fecal positivity rates and colony counts were consistently lower than those for vancomycin/metronidazole from days 4 to 5 of treatment (including post-EOT); however, the only significant difference was in positivity rate at days 9-12 (15% vs 55%, P = .03). Conclusions There were significant reductions in C difficile recovery from both feces and the environment around fidaxomicin versus vancomycin/metronidazole recipients. Therefore, fidaxomicin treatment may lower the C difficile transmission risk by reducing excretion and environmental contamination.

Smooth muscle tumours of the kidney. (Report on two cases).

Abstract: SUMMARY Two cases of smooth muscle tumours of the kidney are reported, one being a leiomyoma in a neonate, and the other a leiomyosarcoma in a female aged 77 years.

Do minimally displaced, closed tibial fractures in children need monitoring for compartment syndrome?

Abstract: Introduction Acute compartment syndrome (ACS) may be seen following tibial fractures in adults. Although the risk of this complication is thought to be lower in children (especially in those under the age of 12 years) it is routine practice in many units to admit all children with this injury for observation. The aim of this study was to ascertain whether all children under the age of 12 presenting with fractures of the tibia merited admission and to provide recommendations on how to manage these patients based on our experience with this injury. Patients and methods We retrospectively studied the clinical and radiographic progress of consecutive patients presenting to our institution with tibial fractures over a 5-year period. Results A total of 159 tibial fractures were seen in the study period. The mean age of patients treated was 5.8 years. 81% of the injuries occurred in the diaphyseal region and 60% involved the tibia only. A total of 9% of injuries were open and overall 66% of fractures were managed non-operatively. No cases of ACS were seen. Discussion Based on our experience we provide a treatment algorithm detailing how children in the under 12 age group presenting with tibial fractures may be managed. Patients with minimally displaced fractures involving the tibia only, whose pain is adequately controlled and who can safely mobilise with suitable parental supervision may be safely discharged from the emergency department in a back slab with early follow up. Although no children under the age of 12 in the present study developed ACS following a fracture of the tibia, certain features such as a history of a high energy injury, displaced fractures or co-existing fibular fractures should raise suspicion that this complication may ensue. In these cases admission and observation may be warranted.

Effects of financial incentives for treatment supporters on tuberculosis treatment outcomes in Swaziland: a pragmatic interventional study

Abstract: Swaziland has the highest national incidence of tuberculosis (TB) in the world, with treatment success rates well below the 85 % international target. Treatment support as part of comprehensive TB services is a core component of the Stop TB Strategy. This study investigated the effects of financial incentives for treatment supporters on TB treatment outcomes in Swaziland. This was a controlled study that compared treatment outcomes for patients with a treatment supporter who received or did not receive a financial incentive. The intervention group had a higher chance of treatment success as compared with the control group: 73 % (95 % confidence intervals [CIs] 66–80 %) versus 60 % (95 % CIs 57–64 %), respectively, p = 0.003. This improvement remained significant when treatment success rates were adjusted for differences in baseline characteristics, with the effect of incentivised treatment supporters on treatment outcomes having an odds ratio (OR) of 1.8. There was also a significant improvement in the death rate in the intervention group, as compared with the control group (10.6 versus 23.5 %, p = <0.001). Incentives provided to TB treatment supporters appear to significantly improve TB treatment outcomes. Incentivising treatment support may be appropriate as an effective addition to support and supervision measures (199 words).

Exploring the delivery of antiretroviral therapy for symptomatic HIV in Swaziland: threats to the successful treatment and safety of outpatients attending regional and district clinics

Abstract: Aim To examine the safety and acceptability of providing antiretroviral therapy (ART) in a resource poor setting. Design Two-stage observational and qualitative study. Setting Rural hospital in Southern Africa. Methods Structured observation using failure modes and effects analysis (FMEA) of the drug supply, dispensing, prescribing and administration processes. The findings from the FMEA were explored further in qualitative interviews with eight health professionals involved in the delivery of ART. To obtain a patient perspective, a stratified sample of 14 patients receiving ART was also interviewed. Results Key vulnerabilities in the process of ART provision include supply problems, poor packaging and labelling, inadequate knowledge among staff and lack of staff. Key barriers to successful patient adherence include transport inconsistency in supply and personal financial difficulties. There is, however, strong evidence of patient commitment and adherence. Implications and conclusion Medication safety is relatively unexplored in the developing world. This study reveals an encouraging resilience in the health system and adherence among patients in the delivery of complex ART. The vulnerabilities identified, however, undermine patient safety and effectiveness of ART. There are implications for drug manufacturers; international aid agencies funding and supplying ART; and local practitioners. FMEA can help identify potential vulnerabilities and inform safety improvement interventions.