Cancer Research Institute

About: Cancer Research Institute is a nonprofit organization based out in New York, New York, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 1061 authors who have published 754 publications receiving 26712 citations.

Effect of a Structured Teaching Module Including Intensive Prophylactic Measures on Reducing the Incidence of Capecitabine-Induced Hand-Foot Syndrome: Results of a Prospective Randomized Phase III Study.

Abstract: Lessons learned A structured teaching module including intensive prophylactic measures to alleviate hand-foot syndrome (HFS) during capecitabine therapy is feasible but ineffective at protecting patients from HFS. Pharmacologic therapeutic interventions should be investigated for the management of this complication. Background Capecitabine-induced hand-foot syndrome (HFS) has a detrimental effect on quality of life. The effect of a structured teaching module including intensive prophylactic measures was evaluated. Methods This non-crossover phase III double-blinded clinical trial randomized patients in a 1:1 ratio to either a control group or to a group administered a structured teaching model including intensive prophylactic measures on HFS administered by a trained oncology nurse at regular intervals (case) versus standard information on HFS care administered by treating clinician (control). The primary endpoint was comparison of fraction of patients in both arms developing at least grade 2 HFS. Results Between June 15, 2016, and April 4, 2018, 280 patients (140 to case and 140 to control) were enrolled. The median number of capecitabine chemotherapy cycles was eight; 269 patients (96%) were evaluable for HFS, of whom 89 patients (33.08%) developed at least grade 2 HFS (grade 2 HFS, 73 patients [26.1%]; grade 3 HFS, 16 patients (5.7%}). There was no difference in at least grade 2 HFS between evaluable case and control arms of the study (control group, 45/135 [33.3%]; case, 44/134 [32.8%]; p = .93). Conclusion The use of a structured teaching module including intensive prophylactic measures was feasible, but this did not reduce the incidence and severity of capecitabine-induced HFS.

Raman spectroscopy for less invasive and online medical applications

Abstract: Applications of optical spectroscopy techniques, such as Fourier Transform Infrared (FTIR), Raman, and fluorescence, in biology and medicine have been actively pursued in recent times Since optical spectroscopic techniques are very sensitive to biochemical composition of the sample under study, they are being pursued as non invasive analytical methodologies Early transformation from healthy to diseased states is attributed to biochemical changes within tissue Efficacy and potential applications of optical spectroscopic techniques in disease diagnosis has been well demonstrated Another attractive feature of optical spectroscopic methods is that data are amenable to multivariate statistical tools Various statistical techniques have been successfully deployed to exploit subtle differences in Raman spectra for diagnostic purpose Principal Component Analysis (PCA) and its derivatives like Linear Discriminate Analysis (LDA) and logistic regression are some of the widely used methods Among optical spectroscopic methods Raman spectroscopy can provide detailed information about chemical composition of the tissue under study and since progression of a disease is accompanied by chemical changes, it can provide the physician with valuable diagnostic and prognostic information Most important attribute of Raman spectroscopy is its in vivo applications, since light can be delivered and collected rapidly via optical fibres which can be incorporated into catheters, endoscopes, cannulas and needles In the present talk we discuss role of Raman spectroscopy in diagnosing cancers We will emphasize on less invasive and non invasive diagnostic applications

A SLAMS dunk for cancer regulators.

Abstract: Genetic regulators of cancer are identified by combining data on global gene expression and DNA copy number.

Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases.

Abstract: We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data. Of the 51,827,813 people from the NHIS data in 2015, 10,879,591 men without prostate cancer who underwent a health examination were analyzed. The risk of prostate cancer was analyzed with stratification by age. Multivariate-adjusted Cox regression analysis was conducted to examine the association between prostate cancer and metabolic diseases by age groups. The risk of prostate cancer increased continuously with age and 59 years may be a point of inflection. The hazard ratio (HR) of prostate cancer development rose sharply as that age point passed. The population with metabolic diseases was more likely to develop prostate cancer than the population without any of these components. In addition, the incidence rate ratio (IRR) decreased from the youngest age group to the age group comprising 55-59 year olds. Beyond this age group, there was a plateau. The relative risk for prostate cancer associated with metabolic diseases also showed divergent associations with age. The risk of prostate cancer increased continuously with age and the peak Youden index was at 59 years. The relative risk for prostate cancer according to metabolic diseases also showed divergent associations beyond 59 years of age. Therefore, setting the age threshold at 59 years would improve the present clinical risk stratification for prostate cancer in Korea.