Institution
Cancer Research Institute
Nonprofit•New York, New York, United States•
About: Cancer Research Institute is a nonprofit organization based out in New York, New York, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 1061 authors who have published 754 publications receiving 26712 citations.
Topics: Cancer, Population, Breast cancer, Cell cycle, Gene
Papers published on a yearly basis
Papers
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78 citations
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TL;DR: The results suggest that dexamethasone may be more effective than prednisolone and that both are well tolerated.
77 citations
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TL;DR: The role of hypoxia on the acquisition of EMT and cancer stemness and the possible association with epigenetic regulation, as well as their therapeutic applications are summarized.
Abstract: A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can occur under oxygen tensions of < 40 mmHg through hypoxia-inducible factors (HIFs), which are considered key mediators in the adaptation to hypoxia. Previous studies have shown that cellular responses to hypoxia are required for EMT and cancer stemness maintenance through HIF-1α and HIF-2α. The principal transcription factors of EMT include Twist, Snail, Slug, Sip1 (Smad interacting protein 1), and ZEB1 (zinc finger E-box-binding homeobox 1). HIFs bind to hypoxia response elements within the promoter region of these genes and also target cancer stem cell-associated genes and mediate transcriptional responses to hypoxia during stem cell differentiation. Acquisition of stemness characteristics in epithelial cells can be induced by activation of the EMT process. The mechanism of these phenotypic changes includes epigenetic alterations, such as DNA methylation, histone modification, chromatin remodeling, and microRNAs. Increased expression of EMT and pluripotent genes also play a role through demethylation of their promoters. In this review, we summarize the role of hypoxia on the acquisition of EMT and cancer stemness and the possible association with epigenetic regulation, as well as their therapeutic applications.
76 citations
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TL;DR: A functional role of NKG2D and its ligands in the rejection of solid organ transplants is established and early “danger” signals associated with transplantation lead to rapid up-regulation of NKg2D ligands.
Abstract: Although the linkage between innate and adaptive immunity in transplantation has been recognized, the mechanisms underlying this cooperation remain to be fully elucidated. In this study, we show that early "danger" signals associated with transplantation lead to rapid up-regulation of NKG2D ligands. A second wave of NKG2D ligand up-regulation is mediated by the adaptive immune response to allografts. Treatment with an Ab to NKG2D was highly effective in preventing CD28-independent rejection of cardiac allografts. Notably, NKG2D blockade did not deplete CD8(+) T cells or NK1.1(+) cells nor affect their migration to the allografts. These results establish a functional role of NKG2D and its ligands in the rejection of solid organ transplants.
74 citations
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TL;DR: In vitro efficacy of developed Tmx-NLC against breast cancer cell lines is evaluated and the hypothesis of targeting ILS after single dose oral administration is confirmed to be correct.
74 citations
Authors
Showing all 1079 results
Name | H-index | Papers | Citations |
---|---|---|---|
Lewis L. Lanier | 159 | 554 | 86677 |
Xavier Estivill | 110 | 673 | 59568 |
Richard D. Kolodner | 105 | 307 | 40928 |
Jay A. Levy | 104 | 451 | 37920 |
Zbigniew Darzynkiewicz | 101 | 689 | 42625 |
Vikas P. Sukhatme | 100 | 317 | 39027 |
Israel Vlodavsky | 98 | 494 | 34150 |
Yung-Jue Bang | 94 | 664 | 46313 |
Naofumi Mukaida | 93 | 368 | 29652 |
Tetsuo Noda | 90 | 318 | 33195 |
George R. Pettit | 89 | 848 | 31759 |
Jo Vandesompele | 88 | 383 | 59368 |
Denis Gospodarowicz | 84 | 208 | 28915 |
Rolf Kiessling | 82 | 299 | 24617 |
Bruce R. Bistrian | 77 | 590 | 25634 |