Cora

About: Cora is a based out in . It is known for research contribution in the topics: Gravity wave & Thermosphere. The organization has 340 authors who have published 351 publications receiving 7650 citations.

Randomized, Controlled, Double-Blind, Cross-Over Trial Assessing Treatment Preference for Pazopanib Versus Sunitinib in Patients With Metastatic Renal Cell Carcinoma: PISCES Study

Abstract: Purpose Patient-reported outcomes may help inform treatment choice in advanced/metastatic renal cell carcinoma (RCC), particularly between approved targeted therapies with similar efficacy. This double-blind cross-over study evaluated patient preference for pazopanib or sunitinib and the influence of health-related quality of life (HRQoL) and safety factors on their stated preference. Patients and Methods Patients with metastatic RCC were randomly assigned to pazopanib 800 mg per day for 10 weeks, a 2-week washout, and then sunitinib 50 mg per day (4 weeks on, 2 weeks off, 4 weeks on) for 10 weeks, or the reverse sequence. The primary end point, patient preference for a specific treatment, was assessed by questionnaire at the end of the two treatment periods. Other end points and analyses included reasons for preference, physician preference, safety, and HRQoL. Results Of 169 randomly assigned patients, 114 met the following prespecified modified intent-to-treat criteria for the primary analysis: exposure...

Tivozanib Versus Sorafenib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma: Results From a Phase III Trial

Abstract: Purpose Tivozanib is a potent and selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor 1 (VEGFR1), -2, and -3. This phase III trial compared tivozanib with sorafenib as initial targeted therapy in patients with metastatic renal cell carcinoma (RCC). Patients and Methods Patients with metastatic RCC, with a clear cell component, prior nephrectomy, measurable disease, and 0 or 1 prior therapies for metastatic RCC were randomly assigned to tivozanib or sorafenib. Prior VEGF-targeted therapy and mammalian target of rapamycin inhibitor were not permitted. The primary end point was progression-free survival (PFS) by independent review. Results A total of 517 patients were randomly assigned to tivozanib (n = 260) or sorafenib (n = 257). PFS was longer with tivozanib than with sorafenib in the overall population (median, 11.9 v 9.1 months; hazard ratio [HR], 0.797; 95% CI, 0.639 to 0.993; P = .042). One hundred fifty-six patients (61%) who progressed on sorafenib crossed over to rece...

A comparison between gravity wave momentum fluxes in observations and climate models

Abstract: Forthefirsttime,aformalcomparisonismadebetweengravitywavemomentumfluxesinmodelsandthose derivedfromobservations. Althoughgravitywavesoccuroverawiderangeofspatialandtemporalscales,the focusofthispaperisonscalesthatarebeingparameterizedinpresentclimatemodels,sub-1000-kmscales.Only observational methodsthatpermitderivationofgravitywavemomentumfluxesoverlargegeographical areas are discussed, and these are from satellite temperature measurements, constant-density long-duration bal- loons,andhigh-vertical-resolutionradiosondedata.Themodelsdiscussedincludetwohigh-resolutionmodels in which gravity waves are explicitly modeled, Kanto and the Community Atmosphere Model, version 5 (CAM5), and three climate models containing gravity wave parameterizations, MAECHAM5, Hadley Centre Global Environmental Model 3 (HadGEM3), and the Goddard Institute for Space Studies (GISS) model. Measurements generally show similar flux magnitudes as in models, except that the fluxes derived from satellite measurements fall off more rapidly with height. This is likely due to limitations on the observable range of wavelengths, although other factors may contribute. When one accounts for this more rapid fall off, the geographical distribution of the fluxes from observations and models compare reasonably well, except for certain features that depend on the specification of the nonorographic gravity wave source functions in the climate models. For instance, both the observed fluxes and those in the high-resolution models are very small at summer high latitudes, but this is not the case for some of the climate models. This comparison between gravity wave fluxes from climate models, high-resolution models, and fluxes derived from observations in- dicates that such efforts offer a promising path toward improving specifications of gravity wave sources in climate models.

Generation of large-scale gravity waves and neutral winds in the thermosphere from the dissipation of convectively generated gravity waves

Abstract: phase speeds of cH � 480–510 m/s, density perturbations as large as jr 0 /r j� 3.6–5% at z = 400 km, relative [O] perturbations as large as � 2–2.5% atz = 300 km, and total electron content perturbations as large as � 8%. This transfer of momentum from local, relatively slow, small scales at the tropopause to global, fast, large scales in the thermosphere is independent of geomagnetic conditions. The various characteristics of these large-scale waves may explain observations of LSTIDs at magnetically quiet times. We also find that this body force creates a localized ‘‘mean’’ horizontal wind in the direction of the body force. For the plume at 2120 UT, the wind is southward with an estimated maximum of vmax �� 400 m s � 1 that is dissipated after � 4h . We also find that the induced body force direction varies throughout the day, depending on the winds in the lower thermosphere.

A chemical model of meteoric ablation

Abstract: . Most of the extraterrestrial dust entering the Earth's atmosphere ablates to produce metal vapours, which have significant effects on the aeronomy of the upper mesosphere and lower thermosphere. A new Chemical Ablation Model (CAMOD) is described which treats the physics and chemistry of ablation, by including the following processes: sputtering by inelastic collisions with air molecules before the meteoroid melts; evaporation of atoms and oxides from the molten particle; diffusion-controlled migration of the volatile constituents (Na and K) through the molten particle; and impact ionization of the ablated fragments by hyperthermal collisions with air molecules. Evaporation is based on thermodynamic equilibrium in the molten meteoroid (treated as a melt of metal oxides), and between the particle and surrounding vapour phase. The loss rate of each element is then determined assuming Langmuir evaporation. CAMOD successfully predicts the meteor head echo appearance heights, observed from incoherent scatter radars, over a wide range of meteoroid velocities. The model also confirms that differential ablation explains common-volume lidar observations of K, Ca and Ca+ in fresh meteor trails. CAMOD is then used to calculate the injection rates into the atmosphere of a variety of elements as a function of altitude, integrated over the meteoroid mass and velocity distributions. The most abundant elements (Fe, Mg and Si) have peak injection rates around 85 km, with Na and K about 8 km higher. The more refractory element Ca ablates around 82 km with a Na:Ca ratio of 4:1, which does therefore not explain the depletion of atomic Ca to Na, by more than 2 orders of magnitude, in the upper mesosphere. Diffusion of the most volatile elements (Na and K) does not appear to be rate-limiting except in the fastest meteoroids. Non-thermal sputtering causes ~35% mass loss from the fastest (~60–70 km s−1) and smallest (10−17–10−13 g) meteoroids, but makes a minor contribution to the overall ablation rate.