Institution
Dalhousie University
Education•Halifax, Nova Scotia, Canada•
About: Dalhousie University is a education organization based out in Halifax, Nova Scotia, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 25660 authors who have published 58465 publications receiving 2082403 citations. The organization is also known as: Dalhousie College & The Governors of Dalhousie College and University.
Papers published on a yearly basis
Papers
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TL;DR: The focus here is on the methods of screening and follow-up, and on a description of the cases identified within a circumscribed region of Nova Scotia, using new research diagnostic criteria (Denckla, 1986).
Abstract: This report describes an epidemiological investigation of the autistic syndrome using new research diagnostic criteria (Denckla, 1986). The focus here is on the methods of screening and follow-up, and on a description of the cases identified within a circumscribed region of Nova Scotia. Autism, as defined by social deviance, language impairment and repetitive or ritualistic behaviours, has a prevalence of 10 per 10,000 and a male to female ratio of 2.5 : 1. These findings are discussed relative to those reported previously.
311 citations
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TL;DR: The results of this meta-analysis demonstrate the superiority of textured over smooth breast implants in decreasing the rate of capsular contracture.
Abstract: Background:Capsular contracture is a common complication associated with the use of breast implants. Numerous randomized controlled trials addressing the efficacy of textured surface breast implants in reducing capsular contracture have yielded nonuniform results. This meta-analysis addresses the us
311 citations
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TL;DR: Effect of Nanoparticles on the Cell Life Cycle Morteza Mahmoudi,* Kayhan Azadmanesh, Mohammad A. Shokrgozar, W. Shane Journeay, and Sophie Laurent
Abstract: Effect of Nanoparticles on the Cell Life Cycle Morteza Mahmoudi,* Kayhan Azadmanesh, Mohammad A. Shokrgozar, W. Shane Journeay, and Sophie Laurent National Cell Bank, Pasteur Institute of Iran, Tehran, 1316943551 Iran Virology Department, Pasteur Institute of Iran, Tehran, 1316943551 Iran Nanotechnology Toxicology Consulting & Training, Inc., Nova Scotia, Canada Faculty of Medicine, Dalhousie Medical School, Dalhousie University, Halifax, Nova Scotia, Canada Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
311 citations
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TL;DR: Divergent genes from Caenorhabditis elegans and Saccharomyces cerevisiae that have been proposed to represent the novel classes delta- and epsilon-tubulin were found to be specifically related to gamma-tubulins from animals and fungi respectively, and therefore are best seen as rapidly evolving orthologues of gamma- Tubulin.
Abstract: The tubulin gene family, which includes alpha-,beta-, and gamma-tubulin subfamilies, is composed of highly conserved proteins which are the principle structural and functional components of eukaryotic microtubules. We are interested in (1) establishing when in eukaryotic evolution the duplications leading to paralogous alpha, beta, and gamma subfamilies occurred and (2) the possible utility of tubulin sequences in reconstructing organismal phylogeny. To broaden the taxonomic representation of alpha-tubulins so that it roughly equals that of beta-tubulins, alpha-tubulin genes from three Microsporidia (Encephalitozoon hellem, Nosema locustae, and Spraguea lophii), two Parabasalia (Monocercomonas sp. and Trichomitus batrachorum), and one Heterolobosean (Acrasis rosea) were sequenced. With these new genes, phylogenetic trees of alpha- and beta-tubulins were constructed and compared. Trees were congruent with each other, but incongruent with other molecular phylogenies. The agreement between alpha- and beta-tubulin trees could arise by the co-adaptation of one molecule to variants of the other as a result of their intimate steric association in microtubules. Thus, these trees may not be providing independent support for the phylogenetic results. However, one of these unexpected results, that microsporidia cluster with fungi, is supported by other circumstantial evidence, and may therefore reflect a real relationship despite the basal position usually assigned to microsporidia. Relationships between the three tubulins were also examined by constructing trees of all three types. These trees were found to be of limited value for determining the position of the root within each subfamily because of the great interfamily distances, but they do confirm the classification of all known genes into three monophyletic subfamilies. Divergent genes from Caenorhabditis elegans and Saccharomyces cerevisiae that have been proposed to represent the novel classes delta- and epsilon-tubulin were found to be specifically related to gamma-tubulins from animals and fungi respectively, and therefore are best seen as rapidly evolving orthologues of gamma-tubulin.
311 citations
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TL;DR: The results suggest that at the intakes observed in this study, the chronic ingestion of uranium in drinking water affects kidney function and that the proximal tubule, rather than the glomerulus, is the site for this interference.
310 citations
Authors
Showing all 25969 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Gordon H. Guyatt | 231 | 1620 | 228631 |
Michael Rutter | 188 | 676 | 151592 |
Mark E. Cooper | 158 | 1463 | 124887 |
Roberto Romero | 151 | 1516 | 108321 |
Rui Zhang | 151 | 2625 | 107917 |
Thomas J. Smith | 140 | 1775 | 113919 |
Dafna D. Gladman | 129 | 1036 | 75273 |
Marcello Tonelli | 128 | 701 | 115576 |
Shi Xue Dou | 122 | 2028 | 74031 |
J. R. Dahn | 120 | 832 | 66025 |
Scott Chapman | 118 | 579 | 46199 |
Kerry S. Courneya | 112 | 608 | 49504 |
Robert C. Haddon | 112 | 577 | 52712 |
Rodney J. Bartlett | 109 | 700 | 56154 |