Institution
Foshan University
Education•Foshan, China•
About: Foshan University is a education organization based out in Foshan, China. It is known for research contribution in the topics: Catalysis & Adsorption. The organization has 3906 authors who have published 4171 publications receiving 40027 citations.
Topics: Catalysis, Adsorption, Biochar, Computer science, Chemistry
Papers published on a yearly basis
Papers
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TL;DR: Molecular dynamics based computational work and experimental studies revealed that the Janus channels of mixed sand layer exhibited greater interaction energy with emulsion droplets for more efficient adsorption, resulting in better demulsification capability and separation performance.
23 citations
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TL;DR: AlCrN/TiSiN nanomultilayer coatings were prepared by co-deposition method with Al30Cr70 and Ti72Si18 targets, and the hardness of nanomulitlayer coatings was increased from 32.1 GPa to 36.5 GPa as mentioned in this paper.
23 citations
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TL;DR: In this paper, the therapeutic potential of exosomes derived from human amniotic fluid stem cells (hAFSC-exo) was investigated using full-thickness skin-wounded rats.
Abstract: Adult wound healing often results in fibrotic scarring that is caused by myofibroblast aggregation. Human amniotic fluid stem cells (hAFSCs) exhibit significantly anti-fibrotic scarring properties during wound healing. However, it is little known whether hAFSCs directly or indirectly (paracrine) contribute to this process. Using the full-thickness skin-wounded rats, we investigated the therapeutic potential of hAFSC-derived exosomes (hAFSC-exo). Our results showed that hAFSC-exo accelerated the wound healing rate and improved the regeneration of hair follicles, nerves, and vessels, as well as increased proliferation of cutaneous cells and the natural distribution of collagen during wound healing. Additionally, hAFSC-exo suppressed the excessive aggregation of myofibroblasts and the extracellular matrix. We identified several miRNAs, including let-7-5p, miR-22-3p, miR-27a-3p, miR-21-5p, and miR-23a-3p, that were presented in hAFSC-exo. The functional analysis demonstrated that these hAFSC-exo-miRNAs contribute to the inhibition of the transforming growth factor-β (TGF-β) signaling pathway by targeting the TGF-β receptor type I (TGF-βR1) and TGF-β receptor type II (TGF-βR2). The reduction of TGF-βR1 and TGF-βR2 expression induced by hAFSC-exo was also confirmed in the healing tissue. Finally, using mimics of miRNAs, we found that hAFSC-exo-miRNAs were essential for myofibroblast suppression during the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition in vitro. In summary, this study is the first to show that exosomal miRNAs used in hAFSC-based therapy inhibit myofibroblast differentiation. Our study suggests that hAFSC-exo may represent a strategic tool for suppressing fibrotic scarring during wound healing.
23 citations
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TL;DR: A novel negative feedback loop is established linking c‐di‐GMP biogenesis and CobB‐mediated protein deacetylation, which modulates the biogenesis of acetyl‐CoA.
Abstract: As a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as bacterial motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis, and DNA supercoiling in many bacteria. Using an Escherichia coli proteome microarray, we found that c-di-GMP strongly binds to CobB. Further, protein deacetylation assays showed that c-di-GMP inhibits the activity of CobB and thereby modulates the biogenesis of acetyl-CoA. Interestingly, we also found that one of the key enzymes directly involved in c-di-GMP production, DgcZ, is a substrate of CobB. Deacetylation of DgcZ by CobB enhances its activity and thus the production of c-di-GMP. Our work establishes a novel negative feedback loop linking c-di-GMP biogenesis and CobB-mediated protein deacetylation.
23 citations
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TL;DR: In this paper, the influence of the porous structures on the molecule distribution after passing through the porous metals was analyzed by molecular dynamics simulation, and the developed porous metals were then used as catalyst supports in a methanol steam reforming microreactor for hydrogen production.
23 citations
Authors
Showing all 3945 results
Name | H-index | Papers | Citations |
---|---|---|---|
Enrico Martinoia | 96 | 260 | 26702 |
Sergey Shabala | 86 | 435 | 26083 |
Boris A. Malomed | 78 | 1312 | 33411 |
Hailong Wang | 69 | 647 | 19652 |
Michael G. Palmgren | 69 | 183 | 16701 |
Xin Lu | 63 | 371 | 13739 |
Lai-Chang Zhang | 62 | 338 | 13627 |
Ying Zhou | 60 | 663 | 14349 |
Ping Xie | 57 | 415 | 12718 |
Yanfeng Gao | 56 | 305 | 10527 |
Yong Liang | 54 | 397 | 9433 |
Jian Zhen Ou | 54 | 161 | 10963 |
Yunbi Xu | 51 | 115 | 11362 |
Bao-Zhu Guo | 49 | 314 | 8482 |
Hao Wang | 48 | 483 | 9286 |