Gannon University

About: Gannon University is a education organization based out in Erie, Pennsylvania, United States. It is known for research contribution in the topics: Computer science & Curriculum. The organization has 611 authors who have published 919 publications receiving 13225 citations. The organization is also known as: Gannon University.

Fear of Falling

Abstract: Since the identification of the post-fall syndrome1 and use of the term “ptophobia” (the phobic reaction to standing or walking)2 in the early 1980s, fear of falling (FOF) has gained recognition as a health problem of older adults. In an attempt to measure this entity, various definitions have evolved. Tinetti and Powell3 described FOF as an ongoing concern about falling that ultimately limits the performance of daily activities. Other authors4,5 have referred to FOF as a patient's loss of confidence in his or her balance abilities. Still other authors6 defined FOF as a general concept that described low fall-related efficacy (low confidence at avoiding falls) and being afraid of falling. Subjects in one study7 indicated they did not describe themselves as being “afraid of falling,” but rather were “worried” about falling. In the early phase of research, FOF was largely believed to be a consequence of falling. Researchers discussed FOF as resulting from the psychological trauma of the fall, leading to reduced activity and subsequent losses in physical capabilities.2,8–10 Recent research, however, has revealed FOF in those who have not fallen4,11,12 and, furthermore, has uncovered a relationship to physical, psychological, and functional changes in older adults.6 Ongoing studies are focusing on the causes of FOF, dispelling misconceptions (eg, FOF being a result of the normal aging process), and identifying the interventions that address FOF most effectively. The researchers, however, agree that FOF is multifactorial in etiology,12,13 and they suggest that FOF may be a more pervasive and serious problem than falls in older adults6,13 and thus deserves attention. The purpose of this update is to increase the reader's awareness of the current findings about FOF, …

Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity

Abstract: Numerous degenerative disorders are associated with elevated levels of prooxidants and declines in mitochondrial aconitase activity. Deficiency in the mitochondrial iron-binding protein frataxin results in diminished activity of various mitochondrial iron-sulfur proteins including aconitase. We found that aconitase can undergo reversible citrate-dependent modulation in activity in response to pro-oxidants. Frataxin interacted with aconitase in a citrate-dependent fashion, reduced the level of oxidant-induced inactivation, and converted inactive [3Fe-4S]1+ enzyme to the active [4Fe-4S]2+ form of the protein. Thus, frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation.