Glenfield Hospital

About: Glenfield Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Extracorporeal membrane oxygenation. The organization has 1382 authors who have published 1812 publications receiving 99238 citations. The organization is also known as: Glenfield General Hospital.

Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial.

Abstract: Aims EPHESUS was a multicentre, double-blind clinical trial in which 6632 patients with acute myocardial infarction (AMI) complicated by LV systolic dysfunction (LVSD) were randomized to receive eplerenone (n = 3319) or placebo (n = 3313). A total of 1580 EPHESUS patients were treated with PCI, which is now the standard treatment for AMI. This EPHESUS substudy examined the effects of eplerenone upon cardiovascular outcomes in PCI-treated patients. Methods and results EPHESUS patients were divided into PCI-treated and non-PCI-treated cohorts, and the effect of eplerenone upon mortality and other major adverse cardiovascular outcomes was assessed in each cohort. The PCI-treated patients (n = 1580) were younger, and had better renal function and fewer co-morbidities than non-PCI-treated patients (n = 5052). Cardiovascular mortality was significantly lower in PCI-treated patients as compared with non-PCI-treated patients (7% vs. 16%, P < 0.0001). However, the incidence of non-fatal events was similar in PCI-treated and non-PCI-treated cohorts. There was no statistical difference between the PCI-treated and non-PCI-treated cohorts in the primary or secondary outcomes of the trial. Eplerenone administration, compared with placebo, in the PCI-treated cohort did not affect PCI-related clinical outcomes, including recurrence of angina, the occurrence of acute coronary syndromes, or the need for further revascularization. Conclusions The beneficial effects of eplerenone in the EPHESUS trial exist for both PCI- and non-PCI-treated AMI patients with LVSD. Eplerenone has minimal, if any, effect upon reducing PCI-related adverse events in the PCI-treated cohort.

Reproducibility of circulatory changes to head‐up tilt in healthy elderly subjects

Abstract: Objective: to assess the reproducibility of the cardiovascular responses to head-up tilt including cardiac output, stroke volume and peripheral resistance, in healthy older subjects using non-invasive methods. Participants: twenty-five healthy community-dwelling volunteers with a mean age of 69"3 years. Methods: the subjects underwent head-up tilt table testing on two occasions at an interval of 6 weeks. Pulse interval and blood pressure data were collected, on a beat-to-beat basis using a non-invasive monitor (Finapres, Ohmeda), during 708 head-up tilt table testing and stored for analysis. Analysis: the pulse interval and blood pressure data for the group were pooled and the relative changes in cardiac output, stroke volume and peripheral resistance were calculated using pulse contour analysis. Results: the systolic blood pressure, pulse interval, cardiac output and stroke volume fell immediately after tilt with a rise in peripheral resistance. These responses were similar, though the baseline systolic blood pressure levels were lower at the second visit (P=0.06). Conclusion: these non-invasively assessed cardiovascular responses to head-up tilt in healthy older subjects show little variation between visits. The reproducibility of the responses in subjects with syncope and autonomic failure warrants further investigation.

The Presence of New MRI Lesions and Cognitive Decline After Cardiac Surgery: A Systematic Review

Abstract: Patients are commonly reported to experience postoperative cognitive decline (POCD) and new ischemic lesions following surgery, which many researchers have hypothesised to result from emboli entering the cerebral circulation during surgery. Modern magnetic resonance imaging techniques have enabled clear and accurate identification of ischemic lesions. However, difficulties in assessing subtle changes in cognitive impairment clinically remain. The purpose of this systematic review is to discuss the literature that has investigated cognitive outcome in relation to new ischaemic brain lesions after cardiac surgery.