Glenfield Hospital

About: Glenfield Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Extracorporeal membrane oxygenation. The organization has 1382 authors who have published 1812 publications receiving 99238 citations. The organization is also known as: Glenfield General Hospital.

Role of stenting in coronary revascularisation

Abstract: Percutaneous treatment for atheromatous coronary disease has developed rapidly in the last 5–10 years. Some technologies, such as laser therapy, have fallen by the wayside as clinical trials and clinical experience demonstrates lack of efficacy or excess complications. Others devices such as intravascular ultrasound are no longer used routinely. Stent use has grown exponentially, however, initially because operators perceived that angioplasty with adjunctive stenting was safer. Developments allowed the procedure to be increasingly undertaken quickly and safely with short inpatient stay. However, treating patients needs to be evidence based. This article highlights the evidence that underpins the clinical impression that stent deployment is now central to percutaneous treatment of coronary artery disease. Atheromatous coronary artery disease (CAD) has a major impact on health and on medical economics. There are 150 000 admissions for acute myocardial infarction in the UK annually, and the prevalence of angina has been estimated to be between 1–3% (up to 1.8 million for a population of 60 million). The incidence of new angina varies from 3.6–7.9%. Gandhiw1 has published an annua1 incidence of 0.44/1000/year in the younger age group (26 000/year) and 2.32/1000/year in patients aged 61–70 years (139 000/year or 2320/million/year). Much of the presentation of CAD is the result of progression, or dynamic change, in the coronary atheromatous plaque. Important treatment aims should be stabilisation of the plaque, restoration of flow, and the alleviation of any flow limitation. Mechanical means to negate the effects of atheromatous obstruction (be they coronary surgery or percutaneous intervention) play an important part in improving the outcome in those patients with CAD. Percutaneous coronary intervention (PCI) has become an increasingly used and successful treatment option over the last 20 years. It has undergone various evolutionary changes and “came of age” in 2000 with the endorsement of routine stent use by the …

Small droplet emission in exhaled breath during different breathing manoeuvres: Implications for clinical lung function testing during COVID-19.

Abstract: 1Department of Respiratory Sciences, University of Leicester, Leicester, UK 2Institute for Lung Health, NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK 3Unit of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 4Atmospheric science, Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden ^Joint first author, *Joint senior author

Eating symptomatology and general psychopathology in patients with anorexia nervosa from China, UK and Spain: a cross-cultural study examining the role of social attitudes

Abstract: Cultural studies exploring differences in the manifestation of anorexia nervosa (AN) have primarily focus on Western and non-Western cultures. However, no study so far has considered the role that social attitudes (i.e. Collectivist vs. Individualist cultural values) have in the clinical manifestations of eating disorders, including AN patients. With this in mind, the aim of this study is to compare eating and general psychopathology in a large sample of individuals diagnosed with AN from China, Spain, and United Kingdom (UK), in order to study the differences according to belonging to Western or non-Western country, or the country's Individualist Index (IDV). The total sample comprised on 544 adults with a diagnosis of AN recruited from People´s Republic of China (n = 72), UK (n = 117), and Spain (n = 355). Assessment measures included the Eating Disorders Inventory and the Symptom Checklist-90-Revised. Our results show significant differences in most of the eating and psychopathological indices between the three countries. Patients from Western societies (Spain and UK) share more similarities regarding psychopathological expression of AN than the non-Western country (China). While Western countries show higher levels of body dissatisfaction, somatization and overall psychopathology, Chinese patients tend to deny or minimize depression, anxiety and other psychopathological symptoms. Besides, the IDV shows cultural differences in the interpersonal sensitivity scale, being AN patients from UK (the more individualistic society) who presented with higher levels of interpersonal sensitivity (i.e. discomfort during interpersonal interactions and more negative expectations concerning interpersonal behavior). In conclusion, our findings suggest that psychopathological expression of AN is better explained by Western/Eastern influence than by individualist/collectivist values. Although the diagnosis for the eating disorder may be the same, differences in the psychopathology comorbid to the eating disorders may suggest the need for treatments to be modified according to the culture.

Localised malignant pleural mesothelioma: a separate clinical entity requiring aggressive local surgery.

Abstract: Objective:Localisedmalignant pleuralmesotheliomas areveryrare andalthoughthere aresporadicreports inthe literatureshowing thatthey have a different biological behaviour compared to diffuse MPM there is no major series published demonstrating results of surgical treatment. We present our experience in treatingthese tumours.Methods:Over an 8-year periodwe performed radical or debulkingsurgery in 218 patients with MPM. Ten of these patients had localised chest wall tumours and a biopsy either highly suspicious or confirming malignant pleural mesothelioma. Theywere all male withan averageageof 65.9(56—80)years. Threeof the tumourswere epithelioid, three biphasicandthree sarcomatoid. They all had chest wall resections, with limited lung resections where the tumours were infiltrating the lung and reconstruction using a double prolene mesh and orthopaedic cement. Perioperative events and long-term survival were analysed and survival was compared to survival following operations for diffuse malignant pleural mesothelioma. Results: There was no 30-day mortality with only two patients suffering from pleural collections that required ultrasound guided drainage 2 and 8 weeks after the operation. Two patients died from disease progression 3 and 10 months after the operation. Using Kaplan—Meier analysis the mean survival was 56 months. Conclusion: Our results suggest that surgery is indicated in treating localised MPM even in T4 (diffuse chest wall involvement) tumours but pleuropneumonectomy is not necessary. These tumoursseemto have a different biologicalbehaviourcomparedto diffuseMPMbut furtherresearch, includingidentification ofpossiblydifferent biological markers is necessary. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

Dynamic Cerebral Autoregulation Changes during Sub-Maximal Handgrip Maneuver

Abstract: Purpose: autoregulation (CA) using the autoregressive moving average technique. Methods: contraction force. Cerebral blood flow velocity, end-tidal CO2 pressure (PETCO2), and noninvasive arterial blood pressure (ABP) were continuously recorded during baseline, HG and recovery. Critical closing pressure (CrCP), resistance area-product (RAP), and time-varying autoregulation index (ARI) were obtained. Results: PETCO2 did not show significant changes during HG maneuver. Whilst ABP increased continuously during the maneuver, to 27% above its baseline value, CBFV raised to a plateau approximately 15% above baseline. This was sustained by a parallel increase in RAP, suggestive of myogenic vasoconstriction, and a reduction in CrCP that could be associated with metabolic vasodilation. The time-varying ARI index dropped at the beginning and end of the maneuver (p,0.005), which could be related to corresponding alert reactions or to different time constants of the myogenic, metabolic and/or neurogenic mechanisms. Conclusion: hanges in dynamic CA during HG suggest a complex interplay of regulatory mechanisms during static exercise that should be considered when assessing the determinants of cerebral blood flow and metabolism.