Institution
Glenfield Hospital
Healthcare•Leicester, United Kingdom•
About: Glenfield Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Extracorporeal membrane oxygenation. The organization has 1382 authors who have published 1812 publications receiving 99238 citations. The organization is also known as: Glenfield General Hospital.
Topics: Population, Extracorporeal membrane oxygenation, Asthma, Genome-wide association study, Lung cancer
Papers published on a yearly basis
Papers
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TL;DR: The study found higher dropout rates from therapy in individuals with T1DM and worse treatment outcome in spite of having no significant differences in eating disorder psychopathology, although individuals withT1DM report misusing insulin.
Abstract: Background
Co-morbidity between Type 1 Diabetes Mellitus (T1DM) and eating disorders (ED) has been previously described; however the effect of this illness on the outcomes for conventional ED treatments has not been previously investigated. This study aims to compare clinical, psychopathological and personality features between two samples of ED individuals: those with comorbid T1DM and those without (No-DM); and to identify differences in treatment outcomes between the groups.
52 citations
TL;DR: An integrative analysis of genetic, transcriptomic and epigenomic data from human kidney is performed to pinpoint plausible molecular pathways of CKD genetic associations.
Abstract: Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.
51 citations
University of Oulu1, Turku University Hospital2, Karolinska University Hospital3, Sahlgrenska University Hospital4, University of Hamburg5, University of Bologna6, Golden Jubilee National Hospital7, Lund University8, Glenfield Hospital9, University of Münster10, University of Lorraine11, Istituto Superiore di Sanità12
TL;DR: Age, female gender, prior cardiac surgery, preoperative acute neurologic events, aortic arch surgery, and increased arterial lactate were associated with increased risk of early mortality after postcardiotomy venoarterial extracorporeal membrane oxygenation.
51 citations
TL;DR: These results challenge the opinion that the presence of a unilateral, asymptomatic carotid stenosis in patients undergoing open cardiac surgery is associated with an increased risk of peri-operative stroke, sufficient to warrant routine prophylactic carOTid revascularisation.
51 citations
TL;DR: This literature showed that there is no gold standard for the execution and implementation of the transfer function and international guidelines should be created to inform the minimal description of the applied technique and the interpretation of transfer function outcomes in scientific research.
51 citations
Authors
Showing all 1385 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nilesh J. Samani | 149 | 779 | 113545 |
| Daniel I. Chasman | 134 | 484 | 72180 |
| Massimo Mangino | 116 | 369 | 84902 |
| Ian D. Pavord | 108 | 575 | 47691 |
| Christopher E. Brightling | 103 | 552 | 44358 |
| Ulf Gyllensten | 100 | 368 | 59219 |
| Pim van der Harst | 99 | 517 | 42777 |
| Andrew J. Wardlaw | 92 | 311 | 33721 |
| Kenneth J. O'Byrne | 87 | 629 | 39193 |
| Paul Burton | 85 | 418 | 42766 |
| Bryan Williams | 82 | 454 | 40798 |
| Marylyn D. Ritchie | 80 | 459 | 32559 |
| John R. Thompson | 78 | 202 | 50475 |
| Maria G. Belvisi | 73 | 269 | 16021 |
| Martin D. Tobin | 72 | 218 | 34028 |