Glenfield Hospital

About: Glenfield Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Extracorporeal membrane oxygenation. The organization has 1382 authors who have published 1812 publications receiving 99238 citations. The organization is also known as: Glenfield General Hospital.

Biological quality control for exercise testing

Abstract: BACKGROUND A study was undertaken to evaluate the use of a biological quality control programme for a computer controlled, breath-by-breath exercise test system over a 2.5 year period. METHODS One healthy volunteer performed a regular progressive treadmill test with breath-by-breath measurements of oxygen uptake (V˙o 2 ), carbon dioxide output (V˙co 2 ), ventilation (V˙e), and the ECG heart rate (HR). Following a familiarisation period, five consecutive tests were performed and the measurements at peak exercise were averaged to give baseline values. All tests were compared with these values. RESULTS A total of 35 tests were recorded. The within subject standard deviation for measurements at peak exercise were 52 ml/min forV˙o 2 , 74 ml/min forV˙co 2 , 3.1 l/min forV˙e, and 3 beats/min for HR. The mean (SE) percentage variation in measurements at peak exercise compared with the baseline values was +0.37 (0.30)% for V˙o 2 , –0.10 (0.39)% for V˙co 2 , –0.88 (0.52)% forV˙e, and +1.2 (0.26)% for HR. The variability present in measurements made during high and moderate intensity exercise (73%V˙o 2 peak) was not significantly different (p>0.05). During the study period the quality control detected a fault on the oxygen analyser which was not apparent from the automatic calibration. CONCLUSIONS Regular quality control using a healthy volunteer allows all components of the breath-by-breath system to be checked simultaneously and in a manner which is consistent with its clinical use. This practice can highlight faults not detected by automatic calibration.

Random squat/stand maneuvers: a novel approach for assessment of dynamic cerebral autoregulation?

Abstract: RFSSMs provided comparable estimates of autoregulatory indices to FFSSMs. Instead of point estimates at the driven frequency, RFSSMs generate a broader power spectrum of changes in arterial blood p...

Ulceration of the lower leg after total knee replacement: A five-year review

Abstract: Ulceration of the lower leg is considered to be a hard' clinical endpoint of venous thrombosis. Total knee replacement (TKR) is a significant risk factor for venous thrombosis of the leg and therefore potentially for ulceration. We sent a postal questionnaire to 244 patients at a minimum of five years after TKR enquiring about the development of ulceration since their TKR. The overall incidence of ulceration, both active and healed, was 8.67% which is similar to that in the age-matched general population (9.6% to 12.6%), as was the prevalence of active ulceration. We also identified no clear association between venographically-confirmed postoperative deep-venous thrombosis (DVT) and the incidence and prevalence of ulcers at five years. We suggest that after TKR DVT is not a significant risk factor for ulceration of the leg and that perioperative chemical thromboprophylaxis may not be justified on these grounds.

Endothelial function in subcutaneous resistance arteries from elderly hypertensive and normotensive subjects.

Abstract: 1. Previous studies have indicated that younger hypertensive subjects may have abnormal endothelium-dependent relaxation, which could contribute to the elevated peripheral resistance seen in established hypertension. This study was designed to examine the functional behaviour of the endothelium of small arteries from elderly hypertensive and normotensive subjects. 2. Resistance arteries were obtained from gluteal biopsies taken under local anaesthesia in 28 subjects of mean age 70 (range 60–76) years, and studied in an isometric myograph. Eighteen subjects had untreated essential hypertension, and 10 were normotensive. 3. After measurement of the contractile response to noradrenaline, relaxation responses to a variety of endothelium-dependent (acetylcholine and bradykinin) and endothelium-independent (iloprost and sodium nitroprusside) mechanisms were assessed in vessels precontracted with noradrenaline. Endothelium-dependent responses were also studied after incubation with N G -nitro-l-arginine to inhibit nitric oxide synthase. 4. There were no significant differences in the contraction or relaxation responses between elderly subjects with or without high blood pressure. Inhibition of nitric oxide synthase prevented any relaxation with acetylcholine and significantly attenuated the relaxation with bradykinin. Near-complete relaxation was however achieved with the endothelium-independent vasodilator sodium nitroprusside. 5. Hypertension in elderly subjects is not associated with a reduction in endothelial vasodilating function in the subcutaneous vessels of the gluteal region compared with age-matched normotensive controls. The results of this study do not support the hypothesis of a defect of resistance artery endothelium-dependent relaxation in the pathophysiology of hypertension in the elderly.