Institution
Glenfield Hospital
Healthcare•Leicester, United Kingdom•
About: Glenfield Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Extracorporeal membrane oxygenation. The organization has 1382 authors who have published 1812 publications receiving 99238 citations. The organization is also known as: Glenfield General Hospital.
Topics: Population, Extracorporeal membrane oxygenation, Asthma, Genome-wide association study, Lung cancer
Papers published on a yearly basis
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TL;DR: In this paper, a correlative analysis of genome-wide platelet RNA expression data from 37 subjects representing the normal range of platelet responsiveness within a cohort of 500 subjects, identified 63 genes in which transcript levels correlated with variation in the platelet response to adenosine diphosphate and/or the collagen-mimetic peptide.
84 citations
National Institutes of Health1, Université de Montréal2, University of Greifswald3, Broad Institute4, Kanazawa University5, Harvard University6, Johns Hopkins University7, Icahn School of Medicine at Mount Sinai8, GlaxoSmithKline9, University of Minnesota10, University of Texas Health Science Center at Houston11, Vanderbilt University12, University of Washington13, University of North Carolina at Chapel Hill14, University of Virginia15, University of Edinburgh16, Erasmus University Rotterdam17, Imperial College London18, University of Ioannina19, University of Turku20, University of Vermont21, Morehouse School of Medicine22, University of Michigan23, Boston University24, Pennsylvania State University25, King Abdulaziz University26, Queen Mary University of London27, Glenfield Hospital28, University of Leicester29, Technische Universität München30, University of Lübeck31, University of Iceland32, Wake Forest University33, University of California, Los Angeles34, Baylor College of Medicine35, Stanford University36, University of Mississippi37, University of Tartu38, Stony Brook University39, Lund University40, Uppsala University41, University of Auckland42, Group Health Cooperative43, Greifswald University Hospital44, University of Wisconsin–Milwaukee45, Fred Hutchinson Cancer Research Center46
TL;DR: The authors' large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
Abstract: Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets’ important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV (PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
84 citations
TL;DR: EGFR expression in MM correlates with epithelioid histology and TN, and may be a target for selective therapies in MM, which is a fatal tumour of increasing incidence which is related to asbestos exposure.
83 citations
TL;DR: It is suggested that LUCADA accurately describes people in England who are diagnosed with lung cancer and can be used to drive health care improvements and so NHS Trust level factors should be studied to explain the previously published regional variations in these outcomes.
83 citations
TL;DR: In patients with postcardiotomy shock treated with VA-ECMO, central cannulation was associated with greater in-hospital mortality than peripheral cannulation and Adjustments for important confounders did not alter results.
83 citations
Authors
Showing all 1385 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nilesh J. Samani | 149 | 779 | 113545 |
| Daniel I. Chasman | 134 | 484 | 72180 |
| Massimo Mangino | 116 | 369 | 84902 |
| Ian D. Pavord | 108 | 575 | 47691 |
| Christopher E. Brightling | 103 | 552 | 44358 |
| Ulf Gyllensten | 100 | 368 | 59219 |
| Pim van der Harst | 99 | 517 | 42777 |
| Andrew J. Wardlaw | 92 | 311 | 33721 |
| Kenneth J. O'Byrne | 87 | 629 | 39193 |
| Paul Burton | 85 | 418 | 42766 |
| Bryan Williams | 82 | 454 | 40798 |
| Marylyn D. Ritchie | 80 | 459 | 32559 |
| John R. Thompson | 78 | 202 | 50475 |
| Maria G. Belvisi | 73 | 269 | 16021 |
| Martin D. Tobin | 72 | 218 | 34028 |