Hartwick College

About: Hartwick College is a education organization based out in Oneonta, New York, United States. It is known for research contribution in the topics: Population & Public opinion. The organization has 223 authors who have published 435 publications receiving 11484 citations. The organization is also known as: Hartwick Seminary & Hawks.

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

Abstract: Polyubiquitin chain topology is thought to direct modified substrates to specific fates, but this function-topology relationship is poorly understood, as are the dynamics and subcellular locations of specific polyubiquitin signals. Experimental access to these questions has been limited because linkage-specific inhibitors and in vivo sensors have been unavailable. Here we present a general strategy to track linkage-specific polyubiquitin signals in yeast and mammalian cells, and to probe their functions. We designed several high-affinity Lys63 polyubiquitin-binding proteins and demonstrate their specificity in vitro and in cells. We apply these tools as competitive inhibitors to dissect the polyubiquitin-linkage dependence of NF-κB activation in several cell types, inferring the essential role of Lys63 polyubiquitin for signaling via the IL-1β and TNF-related weak inducer of apoptosis (TWEAK) but not TNF-α receptors. We anticipate live-cell imaging, proteomic and biochemical applications for these tools and extension of the design strategy to other polymeric ubiquitin-like protein modifications.

The origins of horseback riding

Abstract: The horse is ridden by means of the bit, and the bit leaves its trace on the horse's teeth. The beginnings of horse-riding are here identified by defining and detecting microscopic bit wear on equid teeth, using comparative samples from 4 countries and 25,000 years of prehistory. Scanning electron microscope analysis demonstrates that bit wear is clearly distinguishable from other tooth damage. It first occurs in the Ukraine, USSR, at about 4000 BC. Soon thereafter, mobility became a cultural advantage that transformed Eurasian societies. Riding now appears to be the first major innovation in land transport, pre-dating the wheel.

The Emotional Foundation of Political Cognition: The Impact of Extrinsic Anxiety on the Formation of Political Tolerance Judgments

Abstract: Common sense recognizes emotion's ability to influence judgments. We argue that affective processes, in addition to generating feeling states, also influence how political cognition is manifested. Drawing on the theory of affective intelligence, we examine the role that anxiety plays in how and when people rely on predispositions and when they rely on contemporaneous information in making political tolerance judgments. We report on two experimental studies to test our arguments. In the first study we find that extrinsic anxiety generates a resistance response among subjects who hold a strong predisposition and a receptive response among those who do not. In the second study we present subjects with explicit “frames” exposing them to a pro- or anti-free speech message. We find that extrinsic anxiety enhances responsiveness to frames while an absence of anxiety diminishes the impact of these frames. Taken together these results show that affective processes shape how people make political judgments.

The Arecibo Legacy Fast ALFA Survey: The ALFALFA Extragalactic HI Source Catalog

Abstract: We present the catalog of ~31500 extragalactic HI line sources detected by the completed ALFALFA survey out to z 6.5) detections and ones of lower quality which coincide in both position and recessional velocity with galaxies of known redshift. We review the observing technique, data reduction pipeline, and catalog construction process, focusing on details of particular relevance to understanding the catalog's compiled parameters. We further describe and make available the digital HI line spectra associated with the catalogued sources. In addition to the extragalactic HI line detections, we report nine confirmed OH megamasers and ten OH megamaser candidates at 0.16 < z < 0.22 whose OH line signals are redshifted into the ALFALFA frequency band. Because of complexities in data collection and processing associated with the use of a feed-horn array on a complex single-dish antenna in the terrestrial radio frequency interference environment, we also present a list of suggestions and caveats for consideration by users of the ALFALFA extragalactic catalog for future scientific investigations.

A Longitudinal Study of Ego Identity Development at a Liberal Arts College.

Abstract: Ego identity development in the areas of occupational choice, religion, and political ideology was studied using Marcia's categorization system. The results indicated a significant increase in the frequency of the identity achiever status for occupational choice and corresponding decreases in the frequency of the moratorium and identity diffusion statuses. A significant decrease in the frequency of foreclosures on religion was also found. In those instances where students underwent an identity crisis, the probability of resolving it successfully was very high. High scores on the Cultural Sophistication scale of the College Student Questionnaire-Part 1 were found to be associated with presence in the identity achievement status. For students not in the achiever status as freshmen, an interest in various literary and art forms was predictive of becoming an achiever while in college.