Institution
Hospital de São João
Healthcare•Porto, Portugal•
About: Hospital de São João is a healthcare organization based out in Porto, Portugal. It is known for research contribution in the topics: Internal medicine & Medicine. The organization has 315 authors who have published 147 publications receiving 1354 citations. The organization is also known as: Centro Hospitalar de São João.
Papers published on a yearly basis
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University Hospital Centre Zagreb1, Charles University in Prague2, Amager Hospital3, University of Southern Denmark4, Aarhus University Hospital5, Tartu University Hospital6, Semmelweis University7, Ben-Gurion University of the Negev8, University of Padua9, Lithuanian University of Health Sciences10, Hospital de São João11, University of Porto12, Linköping University13, Örebro University14, Imperial College London15, Hull Royal Infirmary16, Gentofte Hospital17
TL;DR: Whether an East–West gradient in the incidence of inflammatory bowel disease in Europe exists is investigated to find out whether international guidelines for diagnosis and initial treatment are not being followed uniformly by physicians.
Abstract: Objective: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East– ...
343 citations
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TL;DR: The diffusion kurtosis model provides new information regarding breast lesions, providing new insights into microstructural complexity and is able to differentiate lesions that display similar ADC values.
Abstract: To evaluate diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in the differentiation and characterisation of breast lesions. Thirty-six women underwent breast magnetic resonance imaging (MRI) including a DWI sequence with multiple b-values (50–3,000 s/mm2). Mean values for apparent diffusion coefficient (ADC), mean diffusivity (MD) and mean kurtosis (MK) were calculated by lesion type and histological subtype. Differences and correlation between parameters were determined. Forty-four lesions were found. There were significant differences between benign and malignant lesions for all parameters (ADC, p = 0.017; MD, p = 0.028; MK, p = 0.017). ADC and MD were higher for benign (1.96 ± 0.41 × 10−3 and 2.17 ± 0.42 × 10−3 mm2/s, respectively) than for malignant lesions (1.33 ± 0.18 × 10−3 and 1.52 ± 0.50 × 10−3 mm2/s). MK was higher for malignant (0.61 ± 0.27) than benign lesions (0.37 ± 0.18). We found differences between invasive ductal carcinoma (IDC) and fibroadenoma (FA) for all parameters (ADC, MD and MK): p = 0.016, 0.022 and 0.016, respectively. FA and fibrocystic change (FC) showed differences only in MK (p = 0.016). Diffusion in breast lesions follows a non-Gaussian distribution. MK enables differentiation and characterisation of breast lesions, providing new insights into microstructural complexity. To confirm these results, further investigation in a broader sample should be performed. • The diffusion kurtosis model provides new information regarding breast lesions
• MD and MK are valid parameters to characterise tissue microstructure
• MK enables improved lesion differentiation
• MK is able to differentiate lesions that display similar ADC values
101 citations
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TL;DR: In this article, the effects of recurrent urinary tract infections (rUTI) and the impact of prophylaxis on rUTI and patients' quality of life (QoL) were investigated.
Abstract: Introduction
This study investigated the effects of recurrent urinary tract infections (rUTI) and the impact of prophylaxis on rUTI and patients’ quality of life (QoL).
87 citations
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TL;DR: Calcium dobesilate 2 g daily for 2 years shows a significantly better activity than placebo on prevention of BRB disruption, independently of diabetes control.
Abstract: The study was carried out to confirm the effect of calcium dobesilate (CaD) compared to placebo (PLA) on the blood-retinal barrier (BRB) permeability in early diabetic retinopathy (DR). Adults with type II diabetes and early diabetic retinopathy (below level 47 of ETDRS grading and PVPR between 20 and 50×10−6/min, plasma-free fluorescein) were included in this double-blind placebo-controlled study. Treatment was 2 g daily for 24 months. The primary parameter, posterior vitreous penetration ratio (PVPR), was measured every 6 months by fluorophotometry. Secondary parameters were fundus photography, fluorescein angiography and safety assessments. Metabolic control was performed every 3 months. A total of 194 patients started the treatment (98 CaD, 96 PLA) and 137 completed the 24-month study (69 CaD, 68 PLA). Both treatment groups were comparable at baseline, with ETDRS level 10 in about 59% of patients. Mean PVPR change from baseline after 24 months was significantly (P=0.002) lower in the CaD group [−3.87 (SD 12.03)] than in the PLA group [+2.03 (SD 12.86)], corresponding to a 13.2% decrease in the CaD group and a 7.3% increase in the PLA group. PVPR evolution was also analysed by HbA1c classes (<7%, between 7 and 9%, ≥9%) and results confirmed the superiority of CaD independently of the diabetes control level. A highly significant difference [CaD: −3.38 (SD 13.44) versus PLA: +3.50 (SD 13.70)] was also obtained in a subgroup of patients without anti-hypertensive and/or lipid-lowering agents (P=0.002 at 24 months). A further analysis of the secondary parameters showed significant changes in favour of CaD in the evolution from baseline to the last visit of haemorrhages (P=0.029), DR level (P=0.0006) and microaneurysms (P=0.013). Regarding safety, only 2.5% (n=5 patients/events) of all adverse events reported were assessed as possibly or probably related to the test drug, while all serious adverse events were reported as unlikely. There was no statistical difference between groups. Calcium dobesilate 2 g daily for 2 years shows a significantly better activity than placebo on prevention of BRB disruption, independently of diabetes control. Tolerance was very good.
60 citations
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TL;DR: The presence of msI or msAV, but not BV, is independently associated with an increased risk of major cervical cytological abnormalities, butNot with HPV infection, and no significant association was found between deviations of the vaginal milieu and high-risk HPV infection.
Abstract: The purpose of this investigation was to evaluate the impact of the vaginal milieu on the presence of abnormal Pap smears and a positive human papilloma virus (HPV) test. A cross-sectional study was conducted between June 2014 and May 2015, evaluating the vaginal discharge by fresh wet mount microscopy and comparing these data with Pap smear findings. Wet mount slides were scored for bacterial vaginosis (BV), aerobic vaginitis (AV), presence of Candida and Trichomonas vaginalis. Cytologic evaluation was done on all Pap smears according to the Bethesda criteria. The cobas© HPV Test (Roche) was performed for HPV detection. A total of 622 cases were evaluated. The mean age of the patients was 41.6 ± 10.65 years (range 21–75). Eighty-three women (13.3 %) had a cytology result worse than low-grade squamous intraepithelial lesion (LSIL). When comparing this group with the one with normal or minor [atypical squamous cells of undetermined significance (ASC-US) or LSIL] Pap smear abnormalities, there were no differences in the presence of Candida (32.5 % vs. 33.2 %, p = 1.0), absence of lactobacilli (38.6 % vs. 32.5 %, p = 0.32) or BV (20.5 % vs. 13.2 %, p = 0.09). On the other hand, moderate or severe inflammation (msI) (41.0 % vs. 28.8 %, p = 0,04), moderate or severe AV (msAV) (16.9 % vs. 7.2 %, p = 0.009) and msAV/BV (37.3 % vs. 20.0 %, p = 0.001) were more common in women with such major cervical abnormalities. No significant association was found between deviations of the vaginal milieu and high-risk HPV infection. The presence of msI or msAV, but not BV, is independently associated with an increased risk of major cervical cytological abnormalities, but not with HPV infection.
56 citations
Authors
Showing all 338 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fátima Carneiro | 79 | 411 | 22772 |
Manuel Sobrinho-Simões | 69 | 382 | 17761 |
Carla Oliveira | 59 | 234 | 14068 |
José Manuel Lopes | 48 | 289 | 11097 |
Francisco Cruz | 48 | 248 | 7287 |
Fernando Magro | 41 | 268 | 9916 |
Inês Azevedo | 39 | 212 | 6848 |
Luís Delgado | 37 | 238 | 5643 |
Paulo Bettencourt | 36 | 202 | 4486 |
Jorge Correia-Pinto | 32 | 209 | 3488 |
Diogo Ayres-de-Campos | 32 | 152 | 4067 |
Jorge Sa Silva | 31 | 260 | 4435 |
João Bernardes | 30 | 151 | 2994 |
António Sarmento | 28 | 234 | 3057 |
Ana Ferreira | 28 | 113 | 4463 |