Hungkuang University

About: Hungkuang University is a education organization based out in Taichung, Taiwan. It is known for research contribution in the topics: Population & Apoptosis. The organization has 1427 authors who have published 2092 publications receiving 36657 citations. The organization is also known as: Hóngguāng Kējì Dàxué.

Pasireotide Versus Octreotide in Acromegaly: A Head-to-Head Superiority Study

Abstract: Context: Biochemical control reduces morbidity and increases life expectancy in patients with acromegaly. With current medical therapies, including the gold standard octreotide long-acting-release (LAR), many patients do not achieve biochemical control. Objective: Our objective was to demonstrate the superiority of pasireotide LAR over octreotide LAR in medically naive patients with acromegaly. Design and Setting: We conducted a prospective, randomized, double-blind study at 84 sites in 27 countries. Patients: A total of 358 patients with medically naive acromegaly (GH >5 μg/L or GH nadir ≥1 μg/L after an oral glucose tolerance test (OGTT) and IGF-1 above the upper limit of normal) were enrolled. Patients either had previous pituitary surgery but no medical treatment or were de novo with a visible pituitary adenoma on magnetic resonance imaging. Interventions: Patients received pasireotide LAR 40 mg/28 days (n = 176) or octreotide LAR 20 mg/28 days (n = 182) for 12 months. At months 3 and 7, titration to ...

A correlation among safety leadership, safety climate and safety performance

Abstract: There has not been much consensus on the causality of safety climates in the past 25 years. Moreover, there is an overall lack of models specifying the relationship among safety leadership, safety climate and safety performance. On the grounds of social system theory, this study has investigated the potential correlation among them. Self-administered questionnaires that included a safety leadership scale, a safety climate scale and a safety performance scale were used to collect data in four universities in central Taiwan. The survey was conducted among 754 subjects selected via simple random sampling. The number of returned valid questionnaires was 465, and the response rate was 61.67%. Path analysis showed that safety climate partially mediated the relationship between safety leadership and safety performance. Canonical correlation analysis showed that safety controlling, one factor of safety leadership, had main influence on CEOs and managers’ safety commitment and action in safety climate, and on safety organization and management, safety equipment and measures, and accident investigations in safety performance. The results of the statistical analysis indicated that organizational leaders would do well to develop a strategy by which they improve the safety climates within their organizations, which will then have a positive effect on safety performance.