Imperial College London

About: Imperial College London is a education organization based out in London, Westminster, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 90019 authors who have published 209164 publications receiving 9337534 citations. The organization is also known as: Imperial College of Science, Technology and Medicine & Imperial College.

Indication of Electron Neutrino Appearance from an Accelerator-produced Off-axis Muon Neutrino Beam

Abstract: The T2K experiment observes indications of nu(mu) -> nu(mu) e appearance in data accumulated with 1.43 x 10(20) protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with |Delta m(23)(2)| = 2.4 x 10(-3) eV(2), sin(2)2 theta(23) = 1 and sin(2)2 theta(13) = 0, the expected number of such events is 1.5 +/- 0.3(syst). Under this hypothesis, the probability to observe six or more candidate events is 7 x 10(-3), equivalent to 2.5 sigma significance. At 90% C.L., the data are consistent with 0.03(0.04) < sin(2)2 theta(13) < 0.28(0.34) for delta(CP) = 0 and a normal (inverted) hierarchy.

Extra pair paternity in birds: a review of interspecific variation and adaptive function.

Abstract: The application of molecular genetic techniques has revolutionized our view of avian mating systems. Contrary to prior expectations, birds are only very rarely sexually monogamous, with ‘extra-pair offspring’ found in approximately 90% of species. Even among socially monogamous species, over 11% of offspring are, on average, the result of extra-pair paternity (EPP). Based on over 150 molecular genetic studies of EPP in birds, we review two topical areas: (i) ecological explanations for interspecific variation in the rate of EPP; and (ii) evidence bearing on the adaptive function of EPP. We highlight the remaining challenges of understanding the relative roles of genes and ecology in determining variation between taxa in the rate of extra paternity, and testing for differences between extra-pair offspring and those sired within-pair.

Recent Developments in the Chemistry of Cubic Polyhedral Oligosilsesquioxanes

Abstract: 3.6.3. T8R7R′ Compounds (R ) i-Bu) 2127 3.6.4. T8R7R′ Compounds (R ) Et, c-C5H9, or Cy) 2128 3.7. Mass Spectra of POSS Compounds 2128 3.8. Electronic Spectra of POSS Compounds 2130 3.9. NMR and EPR Spectroscopies 2131 3.9.1. Solution 29Si NMR Studies 2131 3.9.2. Other Heteronuclear NMR Studies 2134 3.9.3. EPR Spectra 2134 3.10. Vibrational Spectra of POSS Compounds 2136 3.11. X-ray Photoelectron Spectra of POSS Compounds 2139

The Ponder Policy Specification Language

Abstract: The Ponder language provides a common means of specifying security policies that map onto various access control implementation mechanisms for firewalls, operating systems, databases and Java. It supports obligation policies that are event triggered condition-action rules for policy based management of networks and distributed systems. Ponder can also be used for security management activities such as registration of users or logging and auditing events for dealing with access to critical resources or security violations. Key concepts of the language include roles to group policies relating to a position in an organisation, relationships to define interactions between roles and management structures to define a configuration of roles and relationships pertaining to an organisational unit such as a department. These reusable composite policy specifications cater for the complexity of large enterprise information systems. Ponder is declarative, strongly-typed and object-oriented which makes the language flexible, extensible and adaptable to a wide range of management requirements.

Common variants at 30 loci contribute to polygenic dyslipidemia.

Abstract: Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.