Institution
Imperial College London
Education•London, Westminster, United Kingdom•
About: Imperial College London is a education organization based out in London, Westminster, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 90019 authors who have published 209164 publications receiving 9337534 citations. The organization is also known as: Imperial College of Science, Technology and Medicine & Imperial College.
Topics: Population, Medicine, Context (language use), Cancer, Computer science
Papers published on a yearly basis
Papers
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TL;DR: In this paper, global reaction schemes for the combustion of alkane hydrocarbons up to butane in mixtures with air in premixed and diffusion flames have been derived using analysis of flame structures.
914 citations
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Howard Hughes Medical Institute1, University of Geneva2, Max Planck Society3, University of California, Los Angeles4, University of Lausanne5, Imperial College London6, University College London7, École Polytechnique Fédérale de Lausanne8, Picower Institute for Learning and Memory9, Janelia Farm Research Campus10, University of California, San Francisco11
TL;DR: A chronic cranial window is described to obtain optical access to the mouse cerebral cortex for long-term imaging and the entire dendritic and axonal arbor of individual neurons can be reconstructed.
Abstract: To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons and their synapses need to be studied in the intact brain over extended periods of time. Two-photon excitation laser scanning microscopy (2PLSM), together with expression of fluorescent proteins, enables high-resolution imaging of neuronal structure in vivo. In this protocol we describe a chronic cranial window to obtain optical access to the mouse cerebral cortex for long-term imaging. A small bone flap is replaced with a coverglass, which is permanently sealed in place with dental acrylic, providing a clear imaging window with a large field of view (approximately 0.8-12 mm(2)). The surgical procedure can be completed within approximately 1 h. The preparation allows imaging over time periods of months with arbitrary imaging intervals. The large size of the imaging window facilitates imaging of ongoing structural plasticity of small neuronal structures in mice, with low densities of labeled neurons. The entire dendritic and axonal arbor of individual neurons can be reconstructed.
914 citations
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TL;DR: In this paper, it was shown that the usual supersymmetric algebra is not valid for supersymmymmetric theories with solitons, and the algebra is modified to include the topological quantum numbers as central charges.
914 citations
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University of Kentucky1, University of Florida2, Imperial College London3, University of Pennsylvania4, Rush University Medical Center5, Washington University in St. Louis6, Dartmouth College7, Virginia Commonwealth University8, Yeshiva University9, Duke University10, University of Toronto11, Harvard University12
TL;DR: Based on available evidence, institution-specific protocols should screen for high- risk patients, as blood conservation interventions are likely to be most productive for this high-risk subset of patients.
913 citations
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TL;DR: Advances in comprehensive whole-exome and transcriptome sequencing have defined the genetic landscape of each cholangiocarcinoma subtype, and promising molecular targets for precision medicine have been identified, and are being evaluated in clinical trials, including those exploring immunotherapy.
Abstract: Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features of cholangiocyte differentiation: cholangiocarcinomas are categorized according to anatomical location as intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA). Each subtype has a distinct epidemiology, biology, prognosis, and strategy for clinical management. The incidence of cholangiocarcinoma, particularly iCCA, has increased globally over the past few decades. Surgical resection remains the mainstay of potentially curative treatment for all three disease subtypes, whereas liver transplantation after neoadjuvant chemoradiation is restricted to a subset of patients with early stage pCCA. For patients with advanced-stage or unresectable disease, locoregional and systemic chemotherapeutics are the primary treatment options. Improvements in external-beam radiation therapy have facilitated the treatment of cholangiocarcinoma. Moreover, advances in comprehensive whole-exome and transcriptome sequencing have defined the genetic landscape of each cholangiocarcinoma subtype. Accordingly, promising molecular targets for precision medicine have been identified, and are being evaluated in clinical trials, including those exploring immunotherapy. Biomarker-driven trials, in which patients are stratified according to anatomical cholangiocarcinoma subtype and genetic aberrations, will be essential in the development of targeted therapies. Targeting the rich tumour stroma of cholangiocarcinoma in conjunction with targeted therapies might also be useful. Herein, we review the evolving developments in the epidemiology, pathogenesis, and management of cholangiocarcinoma.
913 citations
Authors
Showing all 90798 results
Name | H-index | Papers | Citations |
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Albert Hofman | 267 | 2530 | 321405 |
David Miller | 203 | 2573 | 204840 |
Tamara B. Harris | 201 | 1143 | 163979 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Peter J. Barnes | 194 | 1530 | 166618 |
Simon D. M. White | 189 | 795 | 231645 |
Patrick W. Serruys | 186 | 2427 | 173210 |
John Hardy | 177 | 1178 | 171694 |
Simon Baron-Cohen | 172 | 773 | 118071 |
Richard H. Friend | 169 | 1182 | 140032 |
Yang Gao | 168 | 2047 | 146301 |
Hongfang Liu | 166 | 2356 | 156290 |
Philippe Froguel | 166 | 820 | 118816 |
Salvador Moncada | 164 | 495 | 138030 |
Dennis R. Burton | 164 | 683 | 90959 |