Institution
Incyte
Company•Wilmington, Delaware, United States•
About: Incyte is a company organization based out in Wilmington, Delaware, United States. It is known for research contribution in the topics: Expression vector & Ruxolitinib. The organization has 1262 authors who have published 1875 publications receiving 75015 citations. The organization is also known as: Incyte Corporation & Incyte Inc..
Topics: Expression vector, Ruxolitinib, Cancer, Polynucleotide, Antibody
Papers published on a yearly basis
Papers
More filters
•
22 Apr 2015TL;DR: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyrinones which are inhibitors of BET proteins such as BRD2, BRD3 and BRD4 and are useful in the treatment of diseases such as cancer.
Abstract: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
22 citations
•
28 Jun 1996TL;DR: The present paper as discussed by the authors provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach.
Abstract: The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
22 citations
••
TL;DR: Capparelli et al. as discussed by the authors proposed a small-molecule inhibitor of PD-L1 called INCB086550, which has biological properties similar to PDL1/PD-1 monoclonal antibodies and may represent an alternative to antibody therapy.
Abstract: Abstract Blocking the activity of the programmed cell death protein 1 (PD-1) inhibitory receptor with therapeutic antibodies against either the ligand (PD-L1) or PD-1 itself has proven to be an effective treatment modality for multiple cancers. Contrasting with antibodies, small molecules could demonstrate increased tissue penetration, distinct pharmacology, and potentially enhanced antitumor activity. Here, we describe the identification and characterization of INCB086550, a novel, oral, small-molecule PD-L1 inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. These data support continued clinical evaluation of INCB086550 as an alternative to antibody-based therapies. Significance: We have identified a potent small-molecule inhibitor of PD-L1, INCB086550, which has biological properties similar to PD-L1/PD-1 monoclonal antibodies and may represent an alternative to antibody therapy. Preliminary clinical data in patients demonstrated increased immune activation and tumor growth control, which support continued clinical evaluation of this approach. See related commentary by Capparelli and Aplin, p. 1413. This article is highlighted in the In This Issue feature, p. 1397
22 citations
•
06 Aug 2007TL;DR: The present invention is directed to [1,2,4]triazolo[4,3-b]triazines and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways as mentioned in this paper.
Abstract: The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
22 citations
••
TL;DR: Ruxolitinib was shown to be more effective than BAT at reducing spleen volume in all patient subgroups regardless of gender, age, mutation status, IPSS risk category, baseline spleen size, MF subtype, or ruxolit inib starting dose.
22 citations
Authors
Showing all 1267 results
Name | H-index | Papers | Citations |
---|---|---|---|
Patrick O. Brown | 183 | 755 | 200985 |
David Botstein | 165 | 468 | 212787 |
Inês Barroso | 113 | 301 | 76241 |
Alessandro M. Vannucchi | 94 | 715 | 35482 |
Ana M. Valdes | 84 | 334 | 26627 |
Mark C. Genovese | 79 | 364 | 26945 |
Michael B. Eisen | 71 | 170 | 89150 |
Jingyue Ju | 61 | 169 | 18952 |
Jeanne F. Loring | 60 | 177 | 14503 |
James Z. Wang | 57 | 225 | 21890 |
Emmett V. Schmidt | 50 | 150 | 9304 |
Günther Sperk | 50 | 124 | 10246 |
Robert C. Newton | 44 | 111 | 7369 |
Magnus Pfahl | 44 | 87 | 8064 |
William V. Williams | 44 | 168 | 7278 |