Institution
Incyte
Company•Wilmington, Delaware, United States•
About: Incyte is a company organization based out in Wilmington, Delaware, United States. It is known for research contribution in the topics: Expression vector & Ruxolitinib. The organization has 1262 authors who have published 1875 publications receiving 75015 citations. The organization is also known as: Incyte Corporation & Incyte Inc..
Topics: Expression vector, Ruxolitinib, Cancer, Polynucleotide, Antibody
Papers published on a yearly basis
Papers
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14 Sep 2000TL;DR: In this paper, the authors provide human proteins involved in cell differentiation (CDIFF) and polynucleotides which identify and encode CDIFF, as well as methods for diagnosing, treating, or preventing disorders associated with expression of CDIFF.
Abstract: The invention provides human proteins involved in cell differentiation (CDIFF) and polynucleotides which identify and encode CDIFF. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CDIFF.
8 citations
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TL;DR: The notable rates of thrombotic and cardiovascular events observed in this analysis, even among patients receiving cytoreductive treatment, highlight the important unmet clinical needs of patients with PV in the VHA.
Abstract: Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality. The Veterans Health Administration (VHA) is the largest integrative health network in the United States. Available data concerning patients with PV in this population are limited. This retrospective observational study evaluated the characteristics, management, and outcomes of patients with PV in the VHA Medical SAS® Dataset (October 1, 2005, to September 30, 2012). Inclusion criteria were ≥ 2 claims for PV (ie, PV diagnostic code was recorded) ≥30 days apart during the identification period, age ≥ 18 years, and continuous health plan enrollment from ≥12 months before the index date until the end of follow-up. All data were analyzed using descriptive statistics. The analysis included 7718 patients (median age, 64 years; male, 98%; white, 64%). The most common comorbidities before the index date were hypertension (72%), dyslipidemia (54%), and diabetes (24%); 33% had a history of smoking. During the follow-up period (median, 4.8 years), most patients did not receive treatment with cytoreductive therapy, including phlebotomy (53%), or antiplatelet agents, such as aspirin (57%). The thrombotic and cardiovascular event rates per 1000 patient-years were 60.5 and 83.8, respectively. Among patients who received cytoreductive treatment, the thrombotic event rate was 48.9 per 1000 patient-years. The overall mortality rate was 51.2 per 1000 patient-years. The notable rates of thrombotic and cardiovascular events observed in this analysis, even among patients receiving cytoreductive treatment, highlight the important unmet clinical needs of patients with PV in the VHA.
8 citations
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31 Jan 2000TL;DR: In this article, a plurality of polynucleotide sequences can be used as probes or array elements, and the composition can also be used for array elements as well as arrays.
Abstract: The present invention relates to a composition comprising a plurality of polynucleotide sequences. The composition can be used as probes or array elements.
8 citations
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09 Dec 2004TL;DR: In this article, the authors proposed a method of treating a HIV infection in a host, such as a human, using a single, once a day, oral dose of β-D-D4FC in an enteric-coated tablet.
Abstract: The disclosed invention is a composition for and a method of treating a HIV infection in a host, such as a human, using a single, once a day, oral dose of β-D-D4FC in an enteric-coated tablet. The enterically coated β-D-D4FC increases the amount of the drug that remains in active form for use in inhibiting the HIV virus in vivo.
8 citations
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28 Feb 1997TL;DR: In this article, a human tumor-associated antigen (PRAT) and polynucleotides are used to identify and encode PRAT. And methods for treating disorders associated with the expression of PRAT are provided.
Abstract: The present invention provides a human tumor-associated antigen (PRAT) and polynucleotides which identify and encode PRAT. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with the expression of PRAT.
8 citations
Authors
Showing all 1267 results
Name | H-index | Papers | Citations |
---|---|---|---|
Patrick O. Brown | 183 | 755 | 200985 |
David Botstein | 165 | 468 | 212787 |
Inês Barroso | 113 | 301 | 76241 |
Alessandro M. Vannucchi | 94 | 715 | 35482 |
Ana M. Valdes | 84 | 334 | 26627 |
Mark C. Genovese | 79 | 364 | 26945 |
Michael B. Eisen | 71 | 170 | 89150 |
Jingyue Ju | 61 | 169 | 18952 |
Jeanne F. Loring | 60 | 177 | 14503 |
James Z. Wang | 57 | 225 | 21890 |
Emmett V. Schmidt | 50 | 150 | 9304 |
Günther Sperk | 50 | 124 | 10246 |
Robert C. Newton | 44 | 111 | 7369 |
Magnus Pfahl | 44 | 87 | 8064 |
William V. Williams | 44 | 168 | 7278 |