Showing papers by "Kent State University published in 2022"

In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

Abstract: Significance Hypothalamic oscillators that generate pulsatile patterns of hormone secretion represent a fundamental physiological feature regulating homeostatic systems. How individual cells within these neural ensembles generate and coordinate episodic activity and resultant pulse secretion is unknown. Recently, arcuate KNDy (kisspeptin/neurokinin B/dynorphin) cells were identified as a critical component of the gonadotrophin-releasing hormone (GnRH) pulse generator required for reproduction. Using in vivo calcium imaging of KNDy neurons in freely moving mice, we reveal that, prior to each GnRH pulse, individual KNDy cells demonstrate synchronized activity with striking temporal order, with subsets of cells behaving as “leaders” or “followers.” Future work to distinguish these novel subpopulations and define mechanisms underlying the temporal ordering of cellular synchronization may provide avenues to regulate pulse secretion.

Rockburst mechanism and the law of energy accumulation and release in mining roadway: a case study

Abstract: Abstract The rockburst dynamic disasters in the process of deep coal mining become more and more serious. Taking the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background, we study the characteristics of mining stress field around roadway, the plastic failure morphological characteristics of surrounding rock and the accumulation/release law of elastic energy before and after burst. An analysis model quantitatively describing the physical process of rockburst in the mining roadway is established, and the calculation method of dynamic release of elastic energy in the physical process of rockburst is educed. The mechanism of rockburst in mining roadway is revealed. The results show that an “L-shaped” stress concentration zone is formed within 100 m of the 23130 working face, and the principal stress ratio of the surrounding rock of the transportation roadway is 2.59–4.26. The change of the direction of the maximum principal stress has a significant effect on the burst appearance characteristics. The failure strength of different sections of the mining roadway is characterized by the elastic energy release value. With the increase of the working face distance, the elastic energy released by burst failure and the expansion variation of failure boundary radius show a nonlinear variation law that tends to decrease steadily after sharp fluctuation. The closer to the working face, the higher the burst risk. At a distance of 10 m from the working surface, the maximum principal stress reaches its maximum value. The butterfly-shaped failure system generated by the surrounding rock of the roadway has energy self-sustainability, and the elastic energy released by the sudden expansion of the butterfly leaf is enough to cause a burst damage of 1.9 magnitude. This work could provide theoretical support for the prediction and prevention of rockburst.

Global Patterns and Controls of Nutrient Immobilization on Decomposing Cellulose in Riverine Ecosystems

Abstract: Microbes play a critical role in plant litter decomposition and influence the fate of carbon in rivers and riparian zones. When decomposing low-nutrient plant litter, microbes acquire nitrogen (N) and phosphorus (P) from the environment (i.e., nutrient immobilization), and this process is potentially sensitive to nutrient loading and changing climate. Nonetheless, environmental controls on immobilization are poorly understood because rates are also influenced by plant litter chemistry, which is coupled to the same environmental factors. Here we used a standardized, low-nutrient organic matter substrate (cotton strips) to quantify nutrient immobilization at 100 paired stream and riparian sites representing 11 biomes worldwide. Immobilization rates varied by three orders of magnitude, were greater in rivers than riparian zones, and were strongly correlated to decomposition rates. In rivers, P immobilization rates were controlled by surface water phosphate concentrations, but N immobilization rates were not related to inorganic N. The N:P of immobilized nutrients was tightly constrained to a molar ratio of 10:1 despite wide variation in surface water N:P. Immobilization rates were temperature-dependent in riparian zones but not related to temperature in rivers. However, in rivers nutrient supply ultimately controlled whether microbes could achieve the maximum expected decomposition rate at a given temperature. Collectively, we demonstrated that exogenous nutrient supply and immobilization are critical control points for decomposition of organic matter.

Resummed Relativistic Dissipative Hydrodynamics

Abstract: In this review, we present the motivation for using relativistic anisotropic hydrodynamics to study the physics of ultrarelativistic heavy-ion collisions. We then highlight the main ingredients of the 3+1D quasiparticle anisotropic hydrodynamics model including the underlying symmetry assumptions and present phenomenological comparisons with experimental data at different collision energies. These comparisons show that anisotropic hydrodynamics can describe many bulk observables of the quark-gluon plasma.

Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota

Abstract: Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial-derived metabolites can shape the metabolic functions of macrophages. Here, we show that antibiotic-induced disruption of the intestinal microbiota dramatically alters both the local metabolite environment and the metabolic functions of macrophages in the colon. Broad-spectrum antibiotic administration in mice increased the expression of the large neutral amino acid transporter LAT1 and accordingly, amino acid uptake. Subsequently, antibiotic administration enhanced the metabolic functions of colonic macrophages, increasing phosphorylation of components of mammalian/mechanistic target of rapamycin signalling pathways, with increased expression of genes involved in glycolysis and oxidative phosphorylation (OXPHOS), increased mitochondrial function, increased rate of extracellular acidification (ECAR; measure of glycolysis) and increased rate of oxygen consumption (OCR; measure of OXPHOS). Small bowel macrophages were less metabolically active than their colonic counterparts, with macrophage metabolism in the small intestine being independent of the microbiota. Finally, we reveal tissue-resident Tim4+ CD4+ macrophages exhibit enhanced fatty acid uptake alongside reduced fatty acid synthesis compared to recruited macrophages. Thus, the microbiota shapes gut macrophage metabolism in a compartment-specific manner, with important implications for monocyte recruitment and macrophage differentiation.

Harnessing the toxicity of dysregulated iron uptake for killing <i>Staphylococcus aureus</i>: reality or mirage?

Abstract: Iron—a double-edged sword in biology! The naturally-occuring lipophilic Fe( iii )-chelator hinokitiol allows for harnessing dysregulated iron uptake to kill Staphylococcus aureus bacteria.

ATHENA detector proposal — a totally hermetic electron nucleus apparatus proposed for IP6 at the Electron-Ion Collider

Abstract: Abstract ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.

Psychological distress of college students during the COVID-19 pandemic

Abstract: Objectives To assess levels of psychological distress among a group of US undergraduate college students during the initial phases of the novel coronavirus (SARS-CoV-2) pandemic. Methods: All undergraduates at Kent State University were surveyed in three randomly selected cohorts on March 18, March 25, and April 1, yielding 3924 valid responses for the weighted dataset (73.8% female, 88.9% White). Distress was assessed using the Kessler Psychological Distress Scale (K6). Data were weighted using known population counts. Results: K6 scores averaged 8.19 ± 5.9, with 44.3% in the moderately elevated range and 23.8% above the cutoff for severe psychological distress.Conclusions: A high proportion of undergraduate university students reported elevated psychological distress as the COVID-19 pandemic unfolded. K6 scores appeared higher than averages from comparison samples. Targeted surveillance can inform public health in mitigating threats to mental health conferred by pandemics. Colleges and universities should anticipate sharply elevated psychological distress during and after the COVID-19 pandemic.

Chirality transmission in macromolecular domains

Abstract: Chiral communications exist in secondary structures of foldamers and copolymers via a network of noncovalent interactions within effective intermolecular force (IMF) range. It is not known whether long-range chiral communication exists between macromolecular tertiary structures such as peptide coiled-coils beyond the IMF distance. Harnessing the high sensitivity of single-molecule force spectroscopy, we investigate the chiral interaction between covalently linked DNA duplexes and peptide coiled-coils by evaluating the binding of a diastereomeric pair of three DNA-peptide conjugates. We find that right-handed DNA triple helices well accommodate peptide triple coiled-coils of the same handedness, but not with the left-handed coiled-coil stereoisomers. This chiral communication is effective in a range (<4.5 nm) far beyond canonical IMF distance. Small-angle X-ray scattering and molecular dynamics simulation indicate that the interdomain linkers are tightly packed via hydrophobic interactions, which likely sustains the chirality transmission between DNA and peptide domains. Our findings establish that long-range chiral transmission occurs in tertiary macromolecular domains, explaining the presence of homochiral pairing of superhelices in proteins.

Explaining the rise of moralizing religions: a test of competing hypotheses using the Seshat Databank

Abstract: The causes, consequences, and timing of the rise of moralizing religions in world history have been the focus of intense debate. Progress has been limited by the availability of quantitative data to test competing theories, by divergent ideas regarding both predictor and outcomes variables, and by differences of opinion over methodology. To address all these problems, we utilize Seshat: Global History Databank, a large storehouse of information designed to test theories concerning the evolutionary drivers of social complexity. In addition to the Big Gods hypothesis, which proposes that moralizing religion contributed to the success of increasingly large-scale complex societies, we consider the role of warfare, animal husbandry, and agricultural productivity in the rise of moralizing religions. Using a broad range of new measures of belief in moralizing supernatural punishment, we find strong support for previous research showing that such beliefs did not drive the rise of social complexity. By contrast, our analyses indicate that intergroup warfare, supported by resource availability, played a major role in the evolution of both social complexity and moralizing religions. Thus, the correlation between social complexity and moralizing religion seems to result from shared evolutionary drivers, rather than from direct causal relationships between these two variables.

“It's more about building trust”: Physical education teachers’ experiences with trauma-informed practices

Abstract: In schools today, student trauma and toxic stress may impact students’ ability to learn. Therefore, this inquiry explored the experiences and knowledge of 27 physical education (PE) teachers in the United States related to trauma and trauma-informed practices. Teachers’ experiences were examined through semi-structured interviews informed by the literature. Employing interpretivist philosophical assumptions, data analysis revealed that teachers utilized four general dimensions related to trauma-informed strategies in their gymnasiums: creating a physically safe and emotionally safe space, formulating positive and healthy relationships with students, developing student responsibility, and guiding students toward self-regulation. These strategies aligned with Souers and Hall's (2019) tenets of fostering resilient learners. Although the teachers did not have prior educational experiences with trauma and trauma-informed practices and minimal professional development, they demonstrated what is possible when working with students who experience trauma and/or toxic stress. By fostering resilient learners and engaging in trauma-informed practices, it is conceivable for P-12 students to have positive and inclusive experiences in PE.

Robust deep hedging

Abstract: We study pricing and hedging under parameter uncertainty for a class of Markov processes which we call generalized affine processes and which includes the Black–Scholes model as well as the constant elasticity of variance (CEV) model as special cases. Based on a general dynamic programming principle, we are able to link the associated nonlinear expectation to a variational form of the Kolmogorov equation which opens the door for fast numerical pricing in the robust framework. The main novelty of the paper is that we propose a deep hedging approach which efficiently solves the hedging problem under parameter uncertainty. We numerically evaluate this method on simulated and real data and show that the robust deep hedging outperforms existing hedging approaches in highly volatile periods.

Meta-Analysis of Antidepressant Pharmacotherapy in Patients Eligible for Cardiac Rehabilitation

Abstract: Many patients exhibit clinically significant depression upon enrollment in cardiac rehabilitation (CR). Antidepressants are a first-line treatment option for depression, but the effectiveness of antidepressants in patients with heart disease is mixed. The purpose of this meta-analysis was to evaluate the efficacy of antidepressants for depression in patients eligible for CR.A meta-analysis was conducted including randomized controlled trials of antidepressants from January 1990 to September 2021 that compared antidepressants with placebo. Random-effects models were used between group effect sizes (Hedges' g ).A total of 13 trials with predominately White (68% ± 12; n =7) male (70% ± 11) samples averaging 61 ± 5 yr compared antidepressants (1128 participants) with placebo (1079 participants). Antidepressants reduced depressive symptoms ( g = 0.17: 95% CI, 0.08-0.27), but the effect was small. Heterogeneity among study effects was low ( I2 = 6.42) and nonsignificant ( Q = 10.75, P = .46), although patients with heart failure ( gHF = 0.05: 95% CI, -0.09 to 0.18) demonstrated smaller effects compared with patients with other cardiovascular disease conditions (g non-HF = 0.22: 95% CI, 0.11-0.32) ( QB [1] = 3.97; P < .05). No study reported safety concerns associated with antidepressants.The effect size of antidepressant pharmacotherapy in this population is small. No trials reported on the combined effects of exercise and pharmacotherapy. If the patient is not suicidal, CR staff may consider patient preference and refer patients for additional treatment as necessary.

Immune checkpoint inhibitor in a case with primary urethral adenocarcinoma with lung metastasis

Abstract: Primary urethral adenocarcinoma is extremely rare, and the clinical experience in optimizing the management is limited. The efficacy of immune checkpoint inhibitors for these patients is not clear. Here, we describe a 52-year-old patient with primary urethral adenocarcinoma accompanied by inguinal lymph nodes and lung metastasis with progressive disease after radiotherapy and multiline chemotherapy. The expression of programmed cell death ligand-1 (PD-L1) was positive. Hence, this patient was treated with tislelizumab, an immune checkpoint inhibitor. The disease is well controlled and the overall survival time is 5 years. Moreover, the patient tolerated the treatment well. To our knowledge, this is the first reported case in which immunotherapy was used for primary urethral adenocarcinoma. The immune checkpoint inhibitors may be a novel option for the treatment of these patients.

Interdisciplinary simulation for nursing and medical students about final conversations: Catalyzing relationships at the end of life (CAREol)

Abstract: Abstract Objectives Final conversations (FCs) go beyond how patients want to be cared for at the end of life (EOL) and focus on messages of love, identity specific, and unique to an individual and relationship that requires self-examination, everyday talk that normalizes a difficult situation, religious/spiritual messages, and if needed, difficult relationship talk to heal broken relationships. The purpose of the Catalyzing Relationships at the End of Life (CAREol) program was to provide interdisciplinary education to nursing and medical students and clinical faculty about facilitating FCs among patients and families. Method This two-part, quasi-experimental program consisted of a cognitive (online) and experiential (live simulation) curriculum experience. Program curriculum, including video vignettes, readings, and live simulation (utilizing actors), was developed by the study team. Reflective journaling and researcher designed pre- and post-tests were used to assess comfort, confidence, importance, and distress regarding FCs and collaboration with other disciplines. Results The pre-/post-test questions demonstrate statistical significance based on a paired t -test with effect sizes supporting the practical importance of the findings for effect size. Preliminary content and thematic analysis of qualitative responses describe categories of the mock team meeting experience and interaction with the actors to change patient and family outcomes. Significance of results Early intervention with the CAREol program provides a framework to help students and clinical faculty facilitate FCs that may result in peace and comfort for patients and families during a difficult time.

Practitioners’ Perspectives on Barriers and Benefits of Telemental Health Services: The Unique Impact of COVID-19 on Resettled U.S. Refugees and Asylees

Abstract: The COVID-19 pandemic and associated sequelae have disproportionately exacerbated refugee mental health due to health disparities, poverty, and unique risk factors. In response to the pandemic, most mental health providers have shifted to virtual platforms. Given the high need for services in this population, it is essential to understand the effectiveness and potential barriers to serving refugees via telehealth. This study is one of the first to examine the extent that socio-cultural and structural barriers impact telemental health services received by resettled refugees during the COVID-19 pandemic. This study also addresses the potential benefits of telemental health service delivery to refugees. We surveyed 85 providers serving refugee and non-refugee clients in the United States. Statistical analyses revealed that more significant socio-cultural and structural barriers, including access to technology, linguistic challenges, and privacy limitations, exist for refugees compared to non-refugee clients. Potential benefits of telemental health for refugees during the pandemic included fewer cancellations, fewer transportation concerns, and better access to childcare. These results highlight the need to address the disparity in telemental health service delivery to refugees to limit inequities for this population.

Dropkick Murphys vs. Scott Walker: Unpacking Populist Ideological Discourse in Digital Space

Abstract: On January 24, 2015, the folk punk band Dropkick Murphys penned a tweet to former Wisconsin Governor Scott Walker that read “please stop using our music in any way…We literally hate you!!!” Within hours, thousands of users interacted with the post and a contentious mediated discussion materialized. By exporting the full conversation using the program BrandWatch and applying Sonja Foss’s ideological criticism approach, I found several recurrent ideological constructions reappear throughout the data. Through comments considering the band’s political activism as alienating, re-envisioning punk rock as right-wing, and framing Dropkick Murphys as inherently un-American and undesirable through Twitter comments, Walker supporters rhetorically dismiss the band and their message. These constructions show how new media audiences discursively construct ideologies to delegitimize opposition along the lines of political affiliation and illustrate the communicative mechanism of populism on a micro-level.

P4TE: PISA switch based traffic engineering in fat-tree data center networks

Abstract: This work presents P4TE, an in-band traffic monitoring, load-aware packet forwarding, and flow rate controlling mechanism for traffic engineering in fat-tree topology-based data center networks using PISA switches. It achieves sub-RTT reaction time to change in network conditions, improved flow completion time, and balanced link utilization. Unlike the classical probe-based monitoring approach, P4TE uses an in-band monitoring approach to identify traffic events in the data plane. Based on these events, it re-adjusts the priorities of the paths. It uses a heuristic-based load-aware forwarding path selection mechanism to respond to changing network conditions and control the flow rate by sending feedback to the end hosts. It is implementable on emerging v1model.p4 architecture-based programmable switches and capable of maintaining the line-rate performance. Our evaluation shows that P4TE uses a small amount of resources in the PISA pipeline and achieves an improved flow completion time than ECMP and HULA.