Institution
Kōchi University
Education•Kochi, Japan•
About: Kōchi University is a education organization based out in Kochi, Japan. It is known for research contribution in the topics: Population & Zircon. The organization has 5314 authors who have published 10056 publications receiving 204869 citations. The organization is also known as: Kōchi Daigaku.
Topics: Population, Zircon, Metamorphism, Hydrothermal circulation, Craton
Papers published on a yearly basis
Papers
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TL;DR: A tool to characterize the results of colocalization experiments in a way so that they are understandable and comparable both qualitatively and quantitatively, using a fuzzy system model and computer simulation.
Abstract: Bridging the gap between qualitative and quantitative colocalization results in fluorescence microscopy studies
115 citations
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TL;DR: In this article, the authors conducted a meta-analysis of 16 cohort studies in Japan and found that stroke risk was most strongly related to MBP and SBP in both sexes and most weakly related to pulse pressure.
Abstract: Background— Information has been sparse on the comparison of 4 blood pressure (BP) indexes (systolic BP [SBP], diastolic BP, pulse pressure, and mean BP [MBP]) in relation to long-term incidence of stroke and myocardial infarction, particularly in middle-aged and older Asians. Methods and Results— The Japan Arteriosclerosis Longitudinal Study Group conducted a meta-analysis of 16 cohort studies in Japan. A total of 48 224 men and women 40 to 89 years of age participated at baseline, and 1231 stroke events and 220 myocardial infarction events occurred during an average 8.4-year follow-up. Multivariate-adjusted hazard ratios with a 1-SD higher value for each BP index were determined by Poisson regression. Analyses were also done in 4 age-sex groups. All 4 BP indexes were significantly related to all stroke risk. Stroke risk was most strongly related to MBP and SBP in both sexes and most weakly related to pulse pressure. Both stroke subtypes, ischemic and hemorrhagic, were most strongly related to MBP and SB...
115 citations
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University of Tokyo1, Nagoya University2, Chiba Institute of Technology3, Osaka University4, University of La Laguna5, Spanish National Research Council6, Japan Aerospace Exploration Agency7, Kōchi University8, Kobe University9, Rikkyo University10, University of Aizu11, National Institute of Advanced Industrial Science and Technology12, Meiji University13, Auburn University14, Planetary Science Institute15, Kindai University16, Brown University17, Johns Hopkins University Applied Physics Laboratory18, Tohoku University19, Centre national de la recherche scientifique20, University of Paris-Sud21, Graduate University for Advanced Studies22, Tokyo City University23, Hiroshima University24, National Institute for Environmental Studies25, University of Liverpool26
TL;DR: The authors conclude that the asteroid experienced a prior period of strong solar heating caused by changes in its orbit, and suggest that Ryugu previously experienced an orbital excursion near the Sun.
Abstract: The near-Earth asteroid (162173) Ryugu is thought to be a primitive carbonaceous object that contains hydrated minerals and organic molecules. We report sample collection from Ryugu's surface by the Hayabusa2 spacecraft on 21 February 2019. Touchdown images and global observations of surface colors are used to investigate the stratigraphy of the surface around the sample location and across Ryugu. Latitudinal color variations suggest the reddening of exposed surface material by solar heating and/or space weathering. Immediately after touchdown, Hayabusa2's thrusters disturbed dark, fine grains that originate from the redder materials. The stratigraphic relationship between identified craters and the redder material indicates that surface reddening occurred over a short period of time. We suggest that Ryugu previously experienced an orbital excursion near the Sun.
115 citations
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TL;DR: Findings indicate that HIF‐1α prevents apoptotic cell death through two mechanisms, including inhibition of cytochrome c release and activation of Akt and ERK.
Abstract: The transcriptional factor hypoxia-inducible factor-1 (HIF-1) plays an important role in solid tumor cell growth and survival. Overexpression of HIF-1alpha has been demonstrated in many human tumors and predicts a poor response to chemoradiotherapy. We examined the HIF-1alpha-induced survival pathways in human oral squamous cell carcinoma cell (OSCC) lines. The results showed that forced expression of HIF-1alpha suppressed hypoxia-induced apoptosis of OSCC lines by inhibiting cytochrome c release from mitochondria. Overexpression of HIF-1alpha inhibited the generation of reactive oxygen species (ROS), elevation of intracellular Ca(2+) concentration, reduction of mitochondrial membrane potential, and cytosolic accumulation of cytochrome c, which resulted in the inactivation of caspase-9 and caspase-3. In addition, antiapoptotic Bcl-2 and Bcl-X(L) levels were increased and pro-apoptotic Bax and Bak levels were decreased in the HIF-1alpha-overexpressing OSCC line. Overexpression of HIF-1alpha also increased the levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK). These findings indicate that HIF-1alpha prevents apoptotic cell death through two mechanisms, including inhibition of cytochrome c release and activation of Akt and ERK.
115 citations
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TL;DR: The authors reported SHRIMP U-Pb zircon ages from K-bentonite beds from different locations in the Xiamaling Formation near Beijing at the northern margin of the North China Craton (NCC).
114 citations
Authors
Showing all 5332 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Christopher Gillberg | 131 | 754 | 67561 |
William J. McKenna | 130 | 528 | 67381 |
Kiyoshi Takeda | 129 | 416 | 109817 |
M. Santosh | 103 | 1344 | 49846 |
Motoharu Seiki | 100 | 348 | 35345 |
H. Phillip Koeffler | 92 | 479 | 29428 |
Jonathan F. Ormes | 89 | 306 | 27022 |
George R. Pettit | 89 | 848 | 31759 |
Christos C. Zouboulis | 88 | 689 | 27614 |
Haibo Zhang | 65 | 422 | 16831 |
Alan M. Bond | 64 | 927 | 23656 |
Motoo Shiro | 64 | 720 | 17786 |
Shun-Ichi Murahashi | 62 | 439 | 14117 |
Eric S. Daar | 62 | 236 | 14205 |