Showing papers by "Kuvempu University published in 2005"
TL;DR: An ethnomedicinal survey was conducted in three villages of Shimoga district of Karnataka, India, using a questionnaire designed by Sinha, R.K., 1996, revealing the utilization of 47 species of plants belonging to 46 genera in 28 families used to treat 9 infectious and 16 non-infectious diseases.
163 citations
TL;DR: Sesamol pretreated lymphocytes were exposed to different doses of gamma-radiation and the cellular changes were estimated by using cytokinesis blocked micronucleus assay and the possible mechanism involved in the radioprotective influence of sESamol is discussed.
141 citations
TL;DR: An array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile, and several compounds exhibited promising inflammation inhibiting and anti-microbial properties.
116 citations
TL;DR: The ethanol extract and the isolated constituent of E. scaber promoted wound-healing activity in all the three wound models and was more significant in deoxyelephantopin-treated animals.
Abstract: Objective : To evaluate the wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn. Materials and Methods : The effect of aqueous ethanol extracts and the isolated compound deoxyelephantopin from E. scaber Linn. (Asteraceae) was evaluated on excision, incision, and dead space wound models in rats. The wound-healing activity was assessed by the rate of wound contraction, period of epithelialization, skin-breaking strength, weight of the granulation tissue, and collagen content. Histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. Results : The ethanol extract and the isolated constituent deoxyelephantopin of E. scaber promoted wound-healing activity in all the three wound models. Significant ( P Conclusion : The wound-healing activity was more significant in deoxyelephantopin-treated animals.
85 citations
TL;DR: Methanol extract of the stem bark of P. marsupium possesses significant hepatoprotective activity, and the toxic effect of CCl4 was controlled significantly by restoration of the levels of serum bilirubin, protein and enzymes as compared to the normal and the standard drug silymarin-treated groups.
Abstract: OBJECTIVE : To evaluate the hepatoprotective activity of Pterocarpus marsupium stem bark extracts against carbon tetrachloride (CCl4)-induced hepatotoxicity. MATERIALS AND METHODS : Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of CCl4 (0.1 ml/kg/day for 10 days). Methanol and aqueous extracts of P. marsupium stem bark were administered to the experimental rats (25 mg/kg/day, p.o. for 14 days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters (total bilirubin, serum protein, alanine aminotransaminase, aspartate aminotransaminase, and alkaline phosphatase activities) and histopathological studies of the liver. RESULTS : In methanol extract-treated animals, the toxic effect of CCl4 was controlled significantly by restoration of the levels of serum bilirubin, protein and enzymes as compared to the normal and the standard drug silymarin-treated groups. Histology of the liver sections of the animals treated with the extracts showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, which further evidenced the hepatoprotective activity. CONCLUSION : Methanol extract of the stem bark of P. marsupium possesses significant hepatoprotective activity.
75 citations
TL;DR: In this paper, the influence of microfabric on the matrix suction of residual soils from Bangalore District by referencing the undisturbed residual soil specimens to their remolded state is determined by the ASTM filter paper method.
36 citations
TL;DR: In this paper, a simple one-pot reaction of 3-formyl-2-mercaptoquinolines 2a-l with 1-chloroacetone, 2-chlorocacetamide, ethyl chloroacetate and 2chloro-1-phenylethanone in presence of catalytic amount of potassium carbonate under microwave irradiation and solvent-free conditions gave thieno[2,3-b]quinolin-2,yl)methanone derivatives 6a-e compounds respectively.
33 citations
TL;DR: In this article, a zinc electroplating from non-cyanide alkaline solution is carried out in the presence of condensation product formed between DL-alanine (DLA) and glutaraldehyde.
Abstract: Zinc electroplating from non-cyanide alkaline solution is carried out in the presence of condensation product formed between DL-alanine (DLA) and glutaraldehyde. The bath constituents and bath variables are optimized through standard Hull cell experiments. The current efficiency and the throwing power are measured. High shift of potential towards more cathodic direction was observed in presence of addition agents. Corrosion resistance test reveals good protection of base metal by zinc coating obtained from the developed electrolyte. SEM photomicrographs show fine-grained deposit in the presence of condensation product. IR spectrum of the scraped deposit shows the inclusion of the condensation product in the deposit during plating. The consumption of brightener in the lab-scale is 6 mLL-1 for 1000 amp-hour.
28 citations
25 citations
20 Dec 2005
TL;DR: The feasibility of the new symbolic PCA method has been successfully tested for face recognition using ORL database and requires less number of features to achieve the same recognition rate.
Abstract: A face recognition technique based on symbolic PCA approach is presented in this paper. The proposed method transforms the face images by extracting knowledge from training samples into symbolic objects, termed as symbolic faces. Symbolic PCA is employed to compute a set of subspace basis vectors for symbolic faces and then to project the symbolic faces into the compressed subspace. New test images are then matched with the images in the database by projecting them onto the basis vectors and finding the nearest symbolic face in the subspace. The feasibility of the new symbolic PCA method has been successfully tested for face recognition using ORL database. As compared to eigenface method, the proposed method requires less number of features to achieve the same recognition rate.
17 citations
TL;DR: All TDCs showed comparatively better anti-microbial activity without much affecting basic physical properties of chitosan such as film-forming capacity, tensile strength, etc, which indicates that ch itosan derivatives with a thiazolidinone moiety might be a better material for wound dressing.
Abstract: Thiazolidinone derivatives (TDCs) were prepared by converting chitosan into chitosan's Schiff's bases (CSBs), followed by treatment with mercaptoacetic acid. Both CSBs and TDCs were tested for antimicrobial activity against four different bacteria. All TDCs showed comparatively better anti-microbial activity without much affecting basic physical properties of chitosan such as film-forming capacity, tensile strength, etc. This indicates that chitosane derivatives with a thiazolidinone moiety might be a better material for wound dressing.
TL;DR: Although the rank-ordering of controls in their performance varied between early season, late-season and harvest assessments, the pre-harvest assessments reflected the superior control by synthetic insecticides to that by agents of natural origin.
TL;DR: Single or multiple intraperitonial doses of drug proved high level activity against the subcutaneous (s.c.) grafted B16 melanoma, significantly increase in life span (ILS 139% and 170%).
Abstract: We have used circular dichroism, hydrodynamic methods, absorbance, and fluorescence titration to study the interaction of 4-anilinopyrimido[4′,5′:4,5] selenolo (2,3- b )quinoline (APSQ) and 4-piperazinopyrimido[4′,5′:4,5] selenolo(2,3- b )quinoline (PPSQ) with DNA. The association constants of APSQ and PPSQ were of the order of 10 4 M −1 . The fluorescence properties at ionic strength 0.01 M are best fit by the neighbor exclusion model, with K = 0.58−9.2 × 10 4 M −1 and an exclusion parameter of 0.9–6.4 bp. Binding to the GC-rich DNA of Micrococcus lysodeikticus was stronger than the binding to calf thymus DNA, suggest that drug binds preferentially to G + C pairs at low ř. CD spectra indicate that stacking of these compounds with DNA induces a strong helicity in the usually disordered structure of this double strand. Viscosity experiments show with sonicated calf thymus DNA with PPSQ an twice increase in slope ( m ) as that with APSQ. PPSQ increases the T m for calf thymus DNA melting by ∼10 °C as binding approaches saturation, with biphasic melting. The cytotoxicities of these compounds on leukemia HL-60, K-562, B16F10 melanoma and Colo-205 are quite similar and inhibition (IC 50 ) was in the range of 0.39–9.80 μM. The anticancer efficacy against B16F10 melanoma has provided evidence of major anticancer activity for PPSQ. Single or multiple intraperitonial (i.p.) doses of drug proved high level activity against the subcutaneous (s.c.) grafted B16 melanoma, significantly increase in life span (ILS 139% and 170%). The aim of this study was to analyze the physiochemical properties of these compounds in an attempt to understand its superior biological activity.
TL;DR: In this article, a simple method for the synthesis of symmetrically substituted 1,8,15,22-tetrachloro phthalocyanines of copper, cobalt, nickel and zinc was described.
TL;DR: In this article, a nucleophilic substitution reaction with hydrazine hydrate in ethanol gave the required 2-substituted-4-hydrazinononaphtho[2,1-b]furo[3,2-d]pyrimidines 3a-c.
Abstract: 2-Substituted-4-oxo-naphtho[2,1-b]furo[3,2-d]pyrimidines la-c on refluxing with phosphorous oxychloride result in the formation of 2-substituted-4-chloronaphtho[2,1-b]furo[3,2-d]pyrimidines 2a-c, which on nucleophilic substitution reaction with hydrazine hydrate in ethanol give the required 2-substituted-4-hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 3a-c. The compounds 3a-c are converted into novel angularly fused pentacyclic heterocyclcs viz. tetrazolo[1,5-c]-pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 4a-c and triazolo[4,3-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 5a-i by reacting with appropriate reagents. Condensation of 3a-c with typical aldehydes afford a series of 4-arylidine-hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 6a-o. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data and have been evaluated for antimicrobial, anthelmintic, anticonvulsant and antipyretic activities.
TL;DR: The relationship between the clastogenic effect observed and process of MPTQ intercalation into DNA and the formation of protein-associated DNA-strand breaks probably promoted by topoisomerase enzymes is established.
Abstract: 8-Methoxypyrimido[4′,5′:4,5]thieno(2,3-b)quinoline-4(3H)-one (MPTQ) is known to have antitumor and cytotoxic activities on various types of tumors. This compound showed a strong clastogenic effect on bone marrow cells of Swiss albino mice treated in vivo (17.5–35 mg/kg body weight). MPTQ induced micronuclei formation (MN) at doses of 17.5, 23.3, and 35 mg/kg. Dose and time-yield effect of MPTQ was studied in the case of chromosome aberration assay. MPTQ induced a statistically significant increase in the frequency of chromosome aberrations and micronuclei induction. The drug induced significant abnormal sperms even in the sperm shape abnormality assay. Based on the data reported in the literature, we have tried to establish the relationship between the clastogenic effect observed and process of MPTQ intercalation into DNA and the formation of protein-associated DNA-strand breaks probably promoted by topoisomerase enzymes.
TL;DR: In this article, a projective φ- recurrent kenmotsu manifold with a non-zero constant sectional curvature is shown to be locally projective polygonal.
Abstract: In this paper we study a projective φ- recurrent Kenmotsu manifold and show that projective φ- recurrent Kenmotsu manifold having a non-zero constant sectional curvature is locally projective φ-symmetric.
TL;DR: In this article, the authors reported a study on the thermo optical properties of some nonlinear materials using the z scan technique using both open aperture and closed aperture z scan transmittance signals were recorded to study the refractive and absorptive nonlinearities.
Abstract: We report a study on the thermo optical properties of some nonlinear materials using the z scan technique. Both open aperture and closed aperture z scan transmittance signals were recorded to study the refractive and absorptive nonlinearities. The samples chosen were metal phthalocyanines viz CoPc, NiPc, ZnPc and CuPc. Dimethyl Formamide (DMF) and Dimethyl Sulphoxide (DMSO) were used as solvents. The laser source was the Q switched Nd: YAG with 10 Hz repetition rate and a pulse width of 7 ns. The Q switched envelope of the pulses give negative nonlinearity in all these samples which can be due to either thermal lens effect or electronic transitions among triplet states. Usually the thermal lens effect is neglected in z scan signals recorded using high repetition rate pulses. In our work, we have also carried out dual beam thermal lens measurements inside the sample, using a low power He-Ne as probe. We used the theory of the thermal lens formalism and also that of the Kerr type nonlinearities to interpret the obtained data. These studies yield the nonlinear optical constants and also the thermo optic constants of the samples under investigation.
20 Dec 2005
TL;DR: The proposed distance measure is asymmetric, addresses object variability, and obeys partial order, and is validated by conducting several experiments on the well-known assertion type of symbolic data sets with known classification results.
Abstract: A recent study on symbolic data analysis literature reveals that symbolic distance measures are playing a major role in solving the pattern recognition and analysis problems. After a careful study on the existing symbolic distance measures, we have identified that most of the existing symbolic distance measures either suffer from generalization or do not address object variability. To alleviate these problems we are proposing new generalized Similarity symbolic distance measure. The proposed distance measure is asymmetric, addresses object variability, and obeys partial order. To leverage the advantages of both fuzzy set theory and symbolic data analysis, conventional classification algorithm that works on the principles of fuzzy equivalence relation has been extended to handle Symbolic data. Efficacies of the proposed techniques are validated by conducting several experiments on the well-known assertion type of symbolic data sets with known classification results.