Kwangwoon University

About: Kwangwoon University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Thin film & Resonator. The organization has 4020 authors who have published 8217 publications receiving 104365 citations.

Fabrication of sensitive enzymatic biosensor based on multi-layered reduced graphene oxide added PtAu nanoparticles-modified hybrid electrode.

Abstract: A highly sensitive amperometric glucose sensor was developed by immobilization of glucose oxidase (GOx) onto multi-layer reduced graphene oxide (MRGO) sheets decorated with platinum and gold flower-like nanoparticles (PtAuNPs) modified Au substrate electrode. The fabricated MRGO/PtAuNPs modified hybrid electrode demonstrated high electrocatalytic activities toward oxidation of H2O2, to which it had a wide linear response that ranged from 0.5 to 8 mM (R2 = 0.997), and high sensitivity of 506.25 μA/mMcm2. Furthermore, glucose oxidase-chitosan composite and cationic polydiallyldimethylammonium chloride (PDDA) were assembled by a casting method on the surface of MRGO/PtAuNPs modified electrode. This as-fabricated hybrid biosensor electrode exhibited high electrocatalytic activity for the detection of glucose in PBS. It demonstrated good analytical properties in terms of a low detection limit of 1 μM (signal-to-noise ratio of 3), short response time (3 s), high sensitivity (17.85 μA/mMcm2), and a wide linear range (0.01–8 mM) for glucose sensing. These results reveal that the newly developed sensing electrode offers great promise for new type enzymatic biosensor applications.

Visible light active CdS@TiO2 core-shell nanostructures for the photodegradation of chlorophenols

Abstract: The presence of chlorophenols in various environmental media has become a human health concern. In this study, homogeneous cadmium sulfide (CdS) sub-microspheres were prepared through a solution phase and hydrothermal method, form cadmium acetate dihydrate and thiourea. CdS@TiO2 core-shell nanostructures were synthesized using the as prepared CdS (1:4), through two steps including the solution phase and hydrothermal methods. The prepared CdS sub-microspheres and CdS@TiO2 were characterized using a number of physico-chemical techniques such as X-ray diffraction (XRD), RAMAN spectroscopy, X-ray photoelectron spectroscopy (XPS), UV–vis Diffuse Reflectance Spectroscopy (UV–vis DRS), Scanning Electron Microscopy (SEM), Transmission Electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). The experimental results demonstrated that the morphology of the CdS sub-microspheres can be easily controlled by changing the ratio of cadmium acetate/thiourea. The SEM analysis revealed that the CdS sub-microspheres prepared by solution phase and hydrothermal methods possess an average size of around 149 and 470 nm respectively. The CdS sub-microspheres and CdS@TiO2 core-shell materials were evaluated for the visible light photocatalytic degradation of 2,4-dichlorophenol and 2,4,6-trichlorophenol. CdS@TiO2 showed up to 20% enhanced photocatalytic activity for the degradation of 2,4-DCP and 2,4,6-TCP compared to pure CdS. Up to 70% of 2,4-DCP and 2,4,6-TCP were removed in 6 h. The enhanced photoactivity can be attributed to the longer lifetime of photo-generated electron − hole pairs from the CdS@TiO2 compared to the pure CdS material.

Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy.

Abstract: In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by a phospholipid monolayer with embedded oleosin fusion proteins. The oleosin was genetically fused to a nanobody of a green fluorescent protein (GFP). A recombinant protein consisting of immunoglobulin-binding protein LG fused to GFP was used to couple the oleosome to an antibody for targeted delivery to breast cancer cells. The lipid core of the oleosome was loaded with magnetic nanoparticles and carmustine as the lipophilic drug. The magnetic oleosome was characterized using transmission electron microscopy and dynamic light scattering. Moreover, the specific delivery of oleosome into the target cancer cell was investigated via confocal microscopy. To examine the cell viability of the delivered oleosome, a conventional 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...