Libera!

About: Libera! is a based out in . It is known for research contribution in the topics: Bellman equation & European union. The organization has 501 authors who have published 571 publications receiving 7962 citations.

Perfluorinated compounds for the non-viral transfer of nucleic acids

Abstract: The invention relates to a compound of general formula (I): A - B - C(F, G')- D - E - F - G - A' or a structure of general formula (II): A - B - C(F', G')- D - B - E - F - G - A' (II), wherein - A is at least one molecule selected from the group of the perfluorocarbons (PFCs), perfluorinated silicon compounds, and/or further perfluorinated compounds, - B is at least one predetermined breaking point in the form of a physically, chemically, or enzymatically severable bond, - C is absent or at least one linker molecule, - D is absent or at least one spacer molecule, - E is at least one molecule selected from the group containing nucleobases, nucleosides, nucleotides, oligonucleotides, nucleic acids, modified nucleobases, modified nucleosides, modified nucleotides, modified oligonucleotides, modified nucleic acids, monomers of peptide nucleic acids, oligomers of peptide nucleic acids, and peptide nucleic acids or other nucleic acid analogs, - F, F' is absent or at least one ligand, - G, G' is absent or at least one marker molecule, - A' is absent or has the meaning of A, and wherein the compounds i), ii), iii), iv), v), vi) are excluded. The invention further relates to the use of said compound for the non-viral transfer of molecule E into a cell, to a pharmaceutical composition containing said compound, and to the use of said pharmaceutical composition.

A matter of life and death: substance‐caused and substance‐related fatalities in Ibiza in 2015

Abstract: This is the pre-peer reviewed version of the following article: Rita Santacroce, et al, 'A matter of life and death: substance-caused and substance-related fatalities in Ibiza in 2015', Human Psychopharmacology: Clinical & Experimental, Vol 32 (3), e2592, May 2017, which has been published in final form at DOI: 101002/hup2592 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving The Accepted Manuscript is under embargo Embargo end date: 18 May 2018

Binary and m-ary encoding in applications of tree-based genetic algorithms for QoS routing

Abstract: Ubiquitous and Pervasive Computing (UPC) applications often have Quality of Service (QoS) requirements. These become constraints for the UPC network infrastructure. In this paper, we refer to Mobile ad Hoc Networks, one of the most important technologies supporting UPC, and investigate on Genetic Algorithms (GAs) for QoS routing. GAs are part of the soft computing paradigm and can solve the NP search of QoS routes with multiple constraints. We elaborate on tree-based GAs, which represent the set of paths from source to destination as a tree and encode them through the crossed junctions. While their most well-known applications use m-ary encoding representing single paths in the chromosomes, in this paper we discuss a binary encoding with the objective of improving the convergence speed. The binary encoding represents classes of paths in the chromosomes and allows local search on classes of paths. These classes are both collectively exhaustive and mutually exclusive. Simulation results compare convergence speed and scalability of GA applications with binary and m-ary encoding in networks with an increasing number of nodes and links per node. As the per-class processing is reason of additional computational cost, an hybrid GA application that uses both binary and m-ary encoding is introduced.

Process for producing a semiconductor memory device comprising mass-storage memory cells and shielded memory cells for storing reserved information

Abstract: A process for manufacturing a semiconductor memory device includes double polysilicon level non-volatile memory cells and shielded single polysilicon level non-volatile memory cells in the same semiconductor material chip. A first memory cell includes a MOS transistor having a first gate electrode and a second gate electrode superimposed and respectively formed by definition in a first and a second layer of conductive material. A second memory cell is shielded by a layer of shielding material for preventing the information stored in the second memory cell from being accessible from the outside. The second memory cell includes a MOS transistor with a floating gate electrode formed simultaneously with the first gate electrode of the first cell by definition of the first layer of conductive material. The layer of shielding material is formed by definition of the second layer of conductive material.