Najran University

About: Najran University is a education organization based out in Najrān, Saudi Arabia. It is known for research contribution in the topics: Photocatalysis & Nanoparticle. The organization has 751 authors who have published 1809 publications receiving 28233 citations.

Increased radiation dose and projected radiation-related lifetime cancer risk in patients with obesity due to projection radiography.

Abstract: Purpose Primarily to evaluate the radiation dose delivered to patients with obesity in projection radiography and its relationship to the patient's size. A secondary purpose is to estimate the subsequent projected radiation-related lifetime cancer risk to patients with obesity compared to normal-weight patients. Method and material Data from 1964 patients from a bariatric clinic in the UK were reviewed with the relevant permission. 630 patients were identified to have a projection radiography history and were included in the study. Patients' dose area product (DAP) data were collected for all projection radiography. Multiple exams in one day including a single DAP reading and exams with no records of DAP and exposure factors were excluded. Correlations were calculated and data analysed to yield the third quartile for each examination using STATA 14. Absorbed doses were generated from PCXMC simulation, utilising DAP data from this study and the UK national diagnostic reference level (NDRL), to calculate the effective risk for patients with obesity compared to patients with normal-weight. Results Patients with obesity received higher DAPs for all examinations included in this study compared to NDRL. Abdominal and lumbar spine radiographs DAPs were the highest (17.6 and 30.31 Gy cm2) compared to the NDRL (2.5 and 4 Gy cm2). Only moderate to low correlations were found between patient's size and DAPs in the abdomen and chest radiographs. The projected radiation-related lifetime cancer risk for patients with obesity is up to 153% higher than for adult patients with normal weight. Conclusion Patients with obesity receive higher DAPs than normal-weight adults which may be in excess of that expected due to their size. Therefore, radiation-related lifetime cancer risk is increased in patients with obesity as a result of medical radiation exposures. This indicates more dose optimisation research is needed in this group of patients to reduce dose rate and variation.

Biocatalytic CsPbX3 Perovskite Nanocrystals: A Self-Reporting Nanoprobe for Metabolism Analysis

Abstract: CsPbX3 perovskite nanocrystals (NCs), with excellent optical properties, have drawn considerable attention in recent years. However, they also suffer from inherent vulnerability and hydrolysis, causing the new understanding or new applications to be difficultly explored. Herein, for the first time, it is discovered that the phospholipid membrane (PM)-coated CsPbX3 NCs have intrinsic biocatalytic activity. Different from other peroxidase-like nanozymes relying on extra chromogenic reagents, the PM-CsPbX3 NCs can be used as a self-reporting nanoprobe, allowing an "add-to-answer" detection model. Notably, the fluorescence of PM-CsPbX3 NCs can be rapidly quenched by adding H2 O2 and then be restored by removing excess H2 O2 . Initiated from this unexpected observation, the PM-CsPbX3 NCs can be explored to prepare multi-color bioinks and metabolite-responsive paper analytical devices, demonstrating the great potential of CsPbX3 NCs in bioanalysis. This is the first report on the discovery of nanozyme-like property of all-inorganic CsPbX3 perovskite NCs, which adds another piece to the nanozyme puzzle and opens new avenues for in vitro disease diagnostics.

Effect of Fluoride on the Morphology and Electrochemical Property of Co3O4 Nanostructures for Hydrazine Detection

Abstract: In this paper, we systematically investigated the influence of fluoride on the morphology and electrochemical property of Co₃O₄ nanostructures for hydrazine detection. The results showed that with the introduction of NH₄F during the synthesis process of Co₃O₄, both Co(CO₃)0.5(OH)·0.11H₂O and Co(OH)F precursors would be generated. To understand the influence of F on the morphology and electrochemical property of Co₃O₄, three Co₃O₄ nanostructures that were respectively obtained from bare Co(CO₃)0.5(OH)·0.11H₂O, Co(OH)F and Co(CO₃)0.5(OH)·0.11H₂O mixtures and bare Co(OH)F were successfully synthesized. The electrochemical tests revealed the sensing performance of prepared Co₃O₄ nanostructures decreased with the increase in the fluoride contents of precursors. The more that dosages of NH₄F were used, the higher crystallinity and smaller specific surface area of Co₃O₄ was gained. Among these three Co₃O₄ nanostructures, the Co₃O₄ that was obtained from bare Co(CO₃)0.5(OH)·0.11H₂O-based hydrazine sensor displayed the best performances, which exhibited a great sensitivity (32.42 μA·mM-1), a low detection limit (9.7 μΜ), and a wide linear range (0.010-2.380 mM), together with good selectivity, great reproducibility and longtime stability. To the best of our knowledge, it was revealed for the first time that the sensing performance of prepared Co₃O₄ nanostructures decreased with the increase in fluoride contents of precursors.