Najran University

About: Najran University is a education organization based out in Najrān, Saudi Arabia. It is known for research contribution in the topics: Photocatalysis & Nanoparticle. The organization has 751 authors who have published 1809 publications receiving 28233 citations.

Epidermal growth factor receptor based active targeting: a paradigm shift towards advance tumor therapy

Abstract: The epidermal growth factor receptor (EGFR) is a cell surface receptor belonging to erythroblastic leukemia viral oncogene homologue (ErbB) family of tyrosine kinase. It plays critical role in the regulation of cell proliferation, survival and differentiation. The EGFR receptor is crucial in a variety of tumor development due to unlikely triggered by receptor overexpression, chromosomal mutation and or ligand-dependent receptor dimerization. The EGFR inhibition established a major therapeutic target in cancer therapy. The signal transduction pathway of EGFR is directly involved in tumor pathogenesis and progression. The combinatorial approach with EGFR inhibitors bring novel therapeutic regime with proved clinical efficacy. This critique briefly addressed EGFR receptor characteristics, worldwide report on various cancers and EGFR based potential targeting modalities in skin, breast, ovary, brain, lungs, pancreas, gastric and colorectal tumors and molecular pathways involved in EGFR targeting.

Knowledge, Attitudes, and Practices of Breast Cancer Screening Methods Among Female Patients in Primary Healthcare Centers in Najran, Saudi Arabia

Abstract: The aim of the present study was to evaluate the knowledge, attitude, and practice of breast cancer screening methods among female patients attending five primary healthcare centers in Najran, Saudi Arabia. A cross-sectional survey was conducted on 500 female patients, and a direct interview questionnaire was used to collect data. Our results indicated a low knowledge about breast cancer, breast self-examination, mammogram and clinical breast examination was 54.4%, 56%, 90.4%, and 83.8%, respectively. Nineteen percent of patients demonstrated a high knowledge of breast self-examination. Breast self-examination was performed by 35% of patients, whereas 15% of patients received mammograms and 19.8% clinical breast examinations. The most common barrier for screening methods of breast cancer was that patients were unaware of half of the screening methods. A total of 20.6% of women did not perform breast self-examinations because they were not well trained, and 26.4% of women did not receive clinical breast examinations because there was no female doctor available. The main source of information among the women patients was social media (52.4%), whereas 8.8% received information through their healthcare provider. In summary, the majority of women demonstrated poor knowledge about breast cancer and screening methods. Additional effort should be put forth through women's healthcare providers to increase the awareness of breast cancer screening. That means we need to continue emphasizing the importance of primary healthcare for early detection of breast cancer in the early stages.

Sensing performance optimization by tuning surface morphology of organic (D-π-A) dye based humidity sensor

Abstract: We present herein the effect of varied humidity levels on the electrical parameters of the (E)-2-{4-[2-(3,4,5-trimethoxybenzylidene) hydrazinyl]phenyl}ethylene-1,1,2-tricarbonitrile (TMBHPET) organic dye based humidity sensor. TMBHPET dye has been synthesized bearing an additional methoxy group substituent at the terminal benzene ring of previously reported (E)-2-(4-(2-(3,4-dimethoxybenzeylidene)hydrazinyl)phenyl)ethane-1,1,2-tricarbonitrile (DMBHPET) dye. The strategic dye design is believed to increase the π-electron polarizability in the dye structure. Capacitive type humidity sensor has been fabricated in planar geometry of Al/TMBHPET/Al and its capacitance has been monitored as a function of relative humidity (RH) level at varied frequencies of ∼1 v AC input bias. A maximum sensitivity ∼46 fF/%RH at 1 kHz has been observed which is almost seven times higher as that of DMBHPET based humidity sensor which may be attributed to the porous surface morphology of TMBHPET sensing film. The sensor has also shown reversible changes in its capacitance with variation in humidity level and hysteresis value has been observed to be 2.4%. The motive of the present study was to increase the sensing parameters of the previously reported humidity sensor utilizing DMBHPET dye, which has been successfully achieved.