Ohio Department of Health

About: Ohio Department of Health is a government organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Public health. The organization has 308 authors who have published 354 publications receiving 14493 citations.

Genetic and epigenetic alterations of steroidogenic factor‑1 in ovarian tumors

Abstract: Steroidogenic factor-1 (SF-1), the product of the NR5A1 gene, is an essential transcription factor that is known to regulate steroidogenesis in ovarian epithelia, including the synthesis of progesterone, a suppressor of ovarian cancer. Expression of the SF-1 protein, a potential ovarian tumor suppressor, has been demonstrated in normal OSE cells, but is lost in most ovarian tumors and ovarian tumor cell lines. We examined loss of heterozygosity (LOH) and promoter methylation as potential mechanisms that may explain the loss of SF-1 protein in ovarian tumor tissues. Genotyping of three NR5A1 SNPs in matched tumor/normal tissues identified LOH in 16/36 (44%) of the ovarian tumors successfully analyzed, and somatic mutations (gain of allele) in 10% of the tumors. Furthermore, a methylation-sensitive restriction enzyme method was used to demonstrate statistically significant (p<0.0001) increase in the frequency of NR5A1 gene methylation in ovarian tumors (36/46; 78%) versus normal ovaries (1/11; 9%). These data suggest that the SF-1 encoding gene exhibits frequent genetic (LOH/base substitution) and epigenetic (methylation) somatic alterations in ovarian tumors. These data also present novel molecular mechanisms that may explain the loss of SF-1 protein in ovarian tumors, and its potential role in ovarian carcinogenesis.

School-Based Survey Participation: Oral Health and BMI Survey of Ohio Third Graders

Abstract: During the 2009–2010 school year, the Ohio Department of Health conducted a statewide oral health and body mass index (BMI) screening survey among 3rd grade children. This marked the fifth school-based survey regarding the oral health of Ohio children since 1987. At 50 %, the participation rate of the 2009–2010 oral health and BMI survey was at the lowest level ever experienced. This study aimed to identify the factors associated with participation rates in a school-based survey. A stratified, random sample of 377 schools was drawn from the list of 1,742 Ohio public elementary schools with third grade students. All third grade children in the sampled schools with parent or guardian consent received an oral health screening and height/weight measurement by trained health professionals. Participation rates at the school level were then combined with data on school characteristics and survey implementation. Predictors of school form return, participation, and refusal rates were assessed by generalized linear modeling (GLM). High student mobility and larger school size were associated with lower form return (p = 0.000 and p = 0.001, respectively) and lower participation rates (p = 0.000 and p = 0.005, respectively). Surveying in the fall or spring (as opposed to winter) significantly decreased form return (p = 0.001 and p = 0.016, respectively) and participation rates (p = 0.008 and p = 0.002, respectively), while being surveyed by internal staff (versus external screeners) significantly increased form return (p = 0.003) and participation rates (p = 0.001). Efforts to increase participation should focus more on schools with higher student mobility and larger size. Additionally, participation could be improved by using internal staff and surveying during winter.

Remembering Patients who Die: Exploring the Meaning Conveyed in Notes to the Researcher:

Abstract: Nurses are confronted with the reality of death and dying as part of their profession and, often times, their daily work. The qualitative data in this article were compiled from unsolicited comment...

Executive summary of evidence-based clinical recommendations for the use of pit-and-fissure sealants: A report of the American Dental Association Council on Scientific Affairs

Abstract: Scientific Affairs convened a panel of experts to evaluate the collective evidence and develop evidence-based clinical recommendations on pit-andfissure sealants. This is the executive summary of the full report, “Evidence-Based Clinical Recommendations for the Use of Pit-and-Fissure Sealants: A Report of the American Dental Association Council on Scientific Affairs,” which is published in the March 2008 issue of The Journal of the American Dental Association and which is available online at “jada.ada.org”. These recommendations regarding use of pit-andfissure sealants are provided as a resource to oral health care professionals. The purpose of this document is to provide a critical evaluation and summary of the relevant scientific evidence and to provide recommendations that will assist clinicians with their decisionmaking process. These recommendations are not a standard of care, but rather a useful tool that can be applied in making evidence-based decisions about sealant use. The recommendations should be integrated with the practitioner’s professional judgment and the individual patient’s needs and preferences.