Institution
Pharmaceutical Product Development
Company•Wilmington, North Carolina, United States•
About: Pharmaceutical Product Development is a company organization based out in Wilmington, North Carolina, United States. It is known for research contribution in the topics: Immunotoxin & Fusion protein. The organization has 402 authors who have published 353 publications receiving 16396 citations.
Topics: Immunotoxin, Fusion protein, Population, Cancer, Antigen
Papers published on a yearly basis
Papers
More filters
•
03 Apr 2015TL;DR: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
12 citations
••
TL;DR: Treatment with lovastatin, in addition to modifications of diet and lifestyle, reduced the rate of first acute major coronary events compared with placebo in a cohort that included participants with average to mildly elevated total levels of cholesterol, and below average levels of high-density lipoprotein cholesterol, women, and elderly subjects.
Abstract: Background Results of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) demonstrated that treatment with lovastatin, in addition to modifications of diet and lifestyle, reduced the rate of first acute major coronary events compared with placebo in a cohort that included participants with average to mildly elevated total levels of cholesterol, and below average levels of high-density lipoprotein cholesterol, women, and elderly subjects. Objective To describe the baseline characteristics of the study's cohort. Design This was a double-blind, placebo-controlled, primary-prevention trial in which Americans with average to mildly elevated total levels of cholesterol [4.65-6.83 mmol/l (180-264 mg/dl)] and no clinical evidence of atherosclerotic cardiovascular disease were randomly allocated either 20-40 mg/day lovastatin or placebo in addition to a low-saturated fat, low-cholesterol diet. Baseline characteristics of the study cohort are described, and the characteristics of a USA reference population based upon NHANES III data are provided for comparison. Results The study includes 5608 men (85%) and 997 women (15%) with mean total cholesterol level 5.71 +/- 0.54 mmol/l (221 +/- 21 mg/dl), low-density lipoprotein cholesterol level 3.88 +/- 0.44 mmol/l (150 +/- 17 mg/dl), high-density lipoprotein cholesterol 0.96 +/- 0.15 mmol/l (37 +/- 6 mg/dl), and median triglyceride level 1.78 +/- 0.86 mmol/l (158 +/- 76 mg/dl). The mean age is 58 years (ranges 45-73 years for men and 55- 73 years for women). The participants are 89% white, 7% Hispanic, and 3% black. Conclusion Results from AFCAPS/TexCAPS will be applicable to large segments of populations; in the USA alone, eight million share the demographic and baseline-lipid-level characteristics of the study cohort.
12 citations
••
TL;DR: "Dual" scoring of recorded site-based ratings of the Montgomery-Asberg Depression Rating Scale can be a relatively unobtrusive surveillance strategy to confirm scores and to identify and remediate rater "outliers" during a study.
11 citations
••
TL;DR: A validated LC-MS/MS assay for the quantitation of 2-Hydroxyglutarate (2-HG), an endogenous oncometabolite, in human brain tumors has been reported and has been successfully applied to human brain tumor samples to support clinical studies.
11 citations
••
TL;DR: The feasibility of oxygen transfer rate measurement to non-destructively monitor plant propagation and vitality of photosynthetically active plant in vitro culture of duckweed was tested using Respiration Activity Monitoring System (RAMOS), and it was proofed to be a sensitive indicator for plant vitality.
Abstract: The feasibility of oxygen transfer rate (OTR) measurement to non-destructively monitor plant propagation and vitality of photosynthetically active plant in vitro culture of duckweed (Wolffia australiana, Lemnaceae) was tested using Respiration Activity Monitoring System (RAMOS). As a result, OTR proofed to be a sensitive indicator for plant vitality. The culture characterization under day/night light conditions, however, revealed a complex interaction between oxygen production and consumption, rendering OTR measurement an unsuitable tool to track plant propagation. However, RAMOS was found to be a useful tool in preliminary studies for process development of photosynthetically active plant in vitro cultures.
11 citations
Authors
Showing all 403 results
Name | H-index | Papers | Citations |
---|---|---|---|
Liangbing Hu | 128 | 480 | 61244 |
Evan A. Stein | 80 | 340 | 36392 |
Steven J. Schwartz | 75 | 313 | 17613 |
Debra A. Schaumberg | 62 | 154 | 15505 |
Lynda A. Szczech | 58 | 175 | 13972 |
Kim L. R. Brouwer | 57 | 247 | 12521 |
Robert S. Wallis | 57 | 147 | 10420 |
Marina A. Dobrovolskaia | 43 | 122 | 10915 |
Al Artaman | 38 | 41 | 61792 |
Bindu Kalesan | 38 | 123 | 8523 |
Stefan Barth | 34 | 238 | 4509 |
Yu.N. Makarov | 32 | 214 | 3578 |
Earl Hubbell | 28 | 76 | 12553 |
Alex Aravanis | 27 | 74 | 5230 |
Izabela Konczak | 24 | 47 | 1770 |