Showing papers in "Trends in Parasitology in 2008"

TL;DR: An updated view on progress in elucidating the epidemiology and pathogenesis of canine leishmaniosis is presented, and the second part focuses on advances in diagnosis, treatment and prevention.

TL;DR: The current understanding ofAMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development.

TL;DR: Information on knowlesi malaria should be included in medical and public health guidelines to encourage the accurate diagnosis and treatment of patients, and monitor the incidence and distribution of cases.

TL;DR: Milestones include: recognition in 1980 of cryptosporidiosis as an acute enteric disease; its emergence as a chronic opportunistic infection that complicates AIDS; acknowledgement of impact on the water industry once it was shown to be waterborne; and study of Cryptosporidium genomics.

TL;DR: The recent discovery of high levels of population genetic variability in O. viverrini in different wetlands in Thailand and Laos, which indicates the presence of sibling species, suggests that the complexity of this epidemiological situation may have been underestimated.

TL;DR: The widespread use of experimental infections indicates that new host-parasite combinations are achieved easily in the laboratory, suggesting that parasites are less specific than they often appear.

TL;DR: Some of the most recent experimental data that shed light on the events underlying preparation and execution of malaria parasite invasion are summarized and how these insights might relate to the development of new antimalarial drugs are summarized.

TL;DR: The nature of the interactions between L. Salmonis and it hosts is reviewed to identify crucial areas that warrant further research to aid understanding of the impact of infection with L. salmonis.

TL;DR: Novel approaches to surveillance will be necessary to ensure that once elimination has been achieved, it is not threatened by a rapid reintroduction of malaria from neighbouring areas.

TL;DR: Interestingly, the antibiotics thiostrepton and rifampin are fast acting and might target additional processes outside the apicoplast, which could cause the 'delayed-death effect' of malaria parasites.

TL;DR: There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalaria drugs.

TL;DR: A background on the lung fluke and its life cycle is provided; key aspects regarding the pathogenesis, diagnosis and treatment of paragonimiasis are summarized; the geographic distribution and prevalence are described; and some recommendations for future research and the control of this important disease in China are made.

TL;DR: An integrated update of the development of the rapidly expanding field of Plasmodium kinomics is proposed to support the realization that PKs represent attractive drug targets in a variety of diseases.

TL;DR: This work compares the metabolic pathways of five Apicomplexans, focusing on their different mitochondrial functions, which highlight their adaptation to their individual intracellular habitats.

TL;DR: The current status of theFBPZ problem in mainland China is reviewed and strategies and measures for effective control of FBPZs are proposed.

TL;DR: A comparison of gregarine morphology, placed in a modern phylogenetic context, helps clarify the earliest stages of apicomplexan evolution, the origin of Cryptosporidium, and specific cases of convergent evolution within the group and beyond.

TL;DR: The mechanisms involved in resistance to isometamidium and diminazene will be discussed, together with some new molecular detection tools that have been developed recently enabling faster diagnosis of drug resistance than conventional laboratory or field tests.

TL;DR: This review summarizes recent progress towards understanding the targets and mechanisms that are important for mediating immunity to malaria.

TL;DR: Interactions between waterfowl and these waters that imply a negative public health impact are presented, reinforcing the need for either better water-quality indicators or for water monitoring specifically for Cryptosporidium, Giardia and microsporidia.

TL;DR: Evidence is provided here from published data of pre-Columbian sites for the peopling of the Americas through trans-oceanic or costal migrations and some intestinal parasites in the New World points to migration routes other than the Bering Land Bridge.

TL;DR: This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008.

TL;DR: There is an urgent need for better cooperation between laboratory scientists and epidemiologists and for regional epidemiological surveillance of these infectious diseases that affect all Mediterranean countries.

TL;DR: Data is reviewed on the interaction of PvRII with DARC and the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax is explored.

TL;DR: Recent progress in the characterization of macrophage migration inhibitory factor orthologs from parasitic nematodes is described, and the roles of these molecules in parasite developmental biology and pathogenesis are discussed.

TL;DR: This opinion article will discuss the recent findings in this research field and assess the possibilities of the inhibition of multidrug resistance transporters such as P-glycoproteins being used in the field.

TL;DR: It is proposed that certain parasites affect fitness-related traits in their hosts to trigger host compensatory responses because these responses can meet the transmission objectives of parasites.

TL;DR: The gametocyte, or sexual blood-stage, of the malaria parasite represents the only stage of the parasite that can be transmitted to the mosquito vector following sexual development within the infected bloodmeal.

TL;DR: The postgenomic era has substantiated information on the specialized molecular machinery of gametocytogenesis and expedited the development of molecular tools to detect and quantify gametocytes, and opened up novel approaches and provided new insights into gametocyte biology.

TL;DR: The current state of knowledge of mosquito-based TBVs is reviewed and the utility of this approach for future vaccine development is discussed, with a focus on malaria transmission-blocking vaccines that target surface antigens of parasite sexual stages.

TL;DR: The recent realization of how intimately and specifically mosquitoes and Plasmodium co-evolve in Nature is driving vector molecular biologists and evolutionary ecologists to move closer to the natural setting under the common umbrella of ‘Ecological immunology’.