Primary Children's Hospital

About: Primary Children's Hospital is a healthcare organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Health care. The organization has 1770 authors who have published 2594 publications receiving 107857 citations. The organization is also known as: Intermountain Primary Children's Medical Center & Intermountain Primary Children's Hospital.

Rapid Detection of Shiga Toxin-Producing Escherichia coli by Optical Immunoassay

Abstract: In a multi-health center study, a new rapid optical immunoassay (OIA) for the detection of Shiga toxin types 1 and 2, the BioStar OIA SHIGATOX kit (Inverness Medical Professional Diagnostics, Inc.), was used to prospectively screen 742 fresh fecal samples for Shiga toxins in parallel with the Premier enterohemorrhagic Escherichia coli (EHEC) kit (Meridian BioScience, Inc.) with and without enrichment of the specimens by incubation in MacConkey broth. Additionally, 85 previously tested frozen fecal samples were assessed as described above. All positive immunoassay results were confirmed by the Vero cell cytotoxicity assay. A further modification of the screening procedure was evaluated on 470 of the prospectively screened specimens. Swabs of growth from conventionally plated stool culture media were subjected to the OIA SHIGATOX, and results were compared with those obtained with the Premier EHEC kit following broth enrichment. Overall, the OIA SHIGATOX kit was significantly more sensitive than the Premier EHEC kit on fresh direct stool specimens (sensitivities, 96.8% and 83.9%, respectively; P < 0.05). The two assays performed equally well with each other on frozen and broth-enriched samples. The colony sweep method used in conjunction with the OIA kit was somewhat more effective at detection of Shiga toxins from growth on agar than the overnight broth enrichment procedure used with the Premier EHEC assay (sensitivities, 100% and 92%, respectively; P < 0.09). Overall, the OIA SHIGATOX kit provided rapid, easy-to-interpret results and was highly effective at detection of Shiga toxin-producing E. coli in fecal samples and overnight cultures.

Pulmonary vasodilatory effects of 12 and 60 parts per million inhaled nitric oxide in children with ventricular septal defect

Abstract: In conclusion, inhaled nitric oxide selectively decreased pulmonary vascular resistance of children with VSD and moderate pulmonary hypertension. During 7-minute intervals, pulmonary vascular resistance was selectively decreased to a similar extent by 12 and 60 ppm inhaled nitric oxide while breathing air or supplemental oxygen. Pulmonary vascular resistance was also decreased by supplemental oxygen alone; however, there was a concomitant increase in systemic vascular resistance. Pulmonary vascular resistance decreased to a greater extent with oxygen and inhaled nitric oxide than with either nitric oxide or oxygen alone.

A randomized prospective evaluation of 3 techniques of postoperative pain management after posterior spinal instrumentation and fusion.

Abstract: STUDY DESIGN Randomized prospective trial. OBJECTIVE To compare the efficacy of intravenous analgesia with single and dual continuous epidural analgesia (CEA) in patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion and instrumentation (PSIF). SUMMARY OF BACKGROUND DATA Pain management after posterior spinal fusion (PSF) for patients with AIS is challenging. Although intravenous patient-controlled analgesia (PCA) is used most commonly, CEA has been found to be safe and effective. Recently, the use of 2 epidural catheters has been thought to be more effective than a single catheter, although the efficacy of using 2 catheters has not been directly compared with a single catheter. METHODS Sixty-six patients with AIS were randomized into 3 groups prior to PSF; PCA, single CEA, and double CEA. Postoperative pain scores as well as side effects, complications, and use of breakthrough medication were collected. Recovery times were also recorded, including hospitalization, times to first bowel movement, and days to walk and climb stairs. Four patients were withdrawn due to the inability to maintain the pain management protocol. RESULTS Pain intensity was most effectively controlled with a double CEA when compared with PCA (P < 0.05) and a single CEA (P < 0.05). Pain control was equivalent in both the PCA and single CEA groups (P = 0.21). The pain control method with the fewest side effects trended toward the single CEA, with an average of 2.55 side effects per patient. The majority of the side effects included pruritis, constipation, and nausea. Late onset neurological events were absent in all patients. CONCLUSION These data document that the double CEA most effectively controls postoperative pain after surgery for AIS. The single CEA trended toward having the fewest side effects when compared with the other techniques. On the basis these findings, we now routinely use the double CEA technique for all patients having surgery for AIS.