Institution
Primary Children's Hospital
Healthcare•Salt Lake City, Utah, United States•
About: Primary Children's Hospital is a healthcare organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Health care. The organization has 1770 authors who have published 2594 publications receiving 107857 citations. The organization is also known as: Intermountain Primary Children's Medical Center & Intermountain Primary Children's Hospital.
Topics: Population, Health care, Transplantation, Poison control, Medicine
Papers published on a yearly basis
Papers
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Cedars-Sinai Medical Center1, University of Erlangen-Nuremberg2, University of Hamburg3, University of Padua4, Stanford University5, Harefield Hospital6, Primary Children's Hospital7, Columbia University8, University of Bern9, Mayo Clinic10, University of Michigan11, University of California, Los Angeles12, Cleveland Clinic13, Johns Hopkins University14, University of Alabama at Birmingham15, Medical University of South Carolina16, University of Alberta17, University of Pittsburgh18, Medical University of Vienna19
TL;DR: A clinical definition for AMR (cardiac dysfunction and/or circulating donor-specific antibody) was no longer believed to be required due to recent publications demonstrating that asymptomatic (no cardiac dysfunction) biopsy-proven AMR is associated with subsequent greater mortality and greater development of cardiac allograft vasculopathy.
Abstract: Background The problem of AMR remains unsolved because standardized schemes for diagnosis and treatment remains contentious. Therefore, a consensus conference was organized to discuss the current status of antibody-mediated rejection (AMR) in heart transplantation. Methods The conference included 83 participants (transplant cardiologists, surgeons, immunologists and pathologists) representing 67 heart transplant centers from North America, Europe, and Asia who all participated in smaller break-out sessions to discuss the various topics of AMR and attempt to achieve consensus. Results A tentative pathology diagnosis of AMR was established, however, the pathologist felt that further discussion was needed prior to a formal recommendation for AMR diagnosis. One of the most important outcomes of this conference was that a clinical definition for AMR (cardiac dysfunction and/or circulating donor-specific antibody) was no longer believed to be required due to recent publications demonstrating that asymptomatic (no cardiac dysfunction) biopsy-proven AMR is associated with subsequent greater mortality and greater development of cardiac allograft vasculopathy. It was also noted that donor-specific antibody is not always detected during AMR episodes as the antibody may be adhered to the donor heart. Finally, recommendations were made for the timing for specific staining of endomyocardial biopsy specimens and the frequency by which circulating antibodies should be assessed. Recommendations for management and future clinical trials were also provided. Conclusions The AMR Consensus Conference brought together clinicians, pathologists and immunologists to further the understanding of AMR. Progress was made toward a pathology AMR grading scale and consensus was accomplished regarding several clinical issues.
314 citations
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Children's Hospital of Wisconsin1, Children's Hospital of Philadelphia2, Medical University of South Carolina3, Emory University4, Cincinnati Children's Hospital Medical Center5, Duke University6, Boston Children's Hospital7, Children's Hospital Los Angeles8, East Carolina University9, Primary Children's Hospital10, University of Michigan11, Columbia University12
TL;DR: Avoiding preterm delivery when possible and close surveillance after Norwood hospitalization for infants with identified risk factors may reduce interstage mortality, which remains high at 12% and is increased with the MBTS compared with the RVPAS if postoperative AVVR is absent or mild.
307 citations
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TL;DR: Among children undergoing mechanical ventilation for acute respiratory failure, the use of a sedation protocol compared with usual care did not reduce the duration of mechanical ventilation and exploratory analyses of secondary outcomes suggest a complex relationship among wakefulness, pain, and agitation.
Abstract: Importance Protocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown Objective To determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care Design, Setting, and Participants Cluster randomized trial conducted in 31 US pediatric intensive care units (PICUs) A total of 2449 children (mean age, 47 years; range, 2 weeks to 17 years) mechanically ventilated for acute respiratory failure were enrolled in 2009-2013 and followed up until 72 hours after opioids were discontinued, 28 days, or hospital discharge Intervention Intervention PICUs (17 sites; n = 1225 patients) used a protocol that included targeted sedation, arousal assessments, extubation readiness testing, sedation adjustment every 8 hours, and sedation weaning Control PICUs (14 sites; n = 1224 patients) managed sedation per usual care Main Outcomes and Measures The primary outcome was duration of mechanical ventilation Secondary outcomes included time to recovery from acute respiratory failure, duration of weaning from mechanical ventilation, neurological testing, PICU and hospital lengths of stay, in-hospital mortality, sedation-related adverse events, measures of sedative exposure (wakefulness, pain, and agitation), and occurrence of iatrogenic withdrawal Results Duration of mechanical ventilation was not different between the 2 groups (intervention: median, 65 [IQR, 41-112] days; control: median, 65 [IQR, 37-121] days) Sedation-related adverse events including inadequate pain and sedation management, clinically significant iatrogenic withdrawal, and unplanned endotracheal tube/invasive line removal were not significantly different between the 2 groups Intervention patients experienced more postextubation stridor (7% vs 4%; P = 03) and fewer stage 2 or worse immobility-related pressure ulcers ( P = 001) In exploratory analyses, intervention patients had fewer days of opioid administration (median, 9 [IQR, 5-15] days vs 10 [IQR, 4-21] days; P = 01), were exposed to fewer sedative classes (median, 2 [IQR, 2-3] classes vs 3 [IQR, 2-4] classes; P P = 004) than control patients, respectively; however, intervention patients had more days with any report of a pain score ≥4 (median, 50% [IQR, 27%-67%] of days vs 23% [IQR, 0%-46%] of days; P P = 003), respectively Conclusions and Relevance Among children undergoing mechanical ventilation for acute respiratory failure, the use of a sedation protocol compared with usual care did not reduce the duration of mechanical ventilation Exploratory analyses of secondary outcomes suggest a complex relationship among wakefulness, pain, and agitation Trial Registration clinicaltrialsgov Identifier:NCT00814099
307 citations
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TL;DR: The authors assessed the rate of fusion, surgery-related complications, and lessons learned after C1–2 transarticular screw fixation in an adult patient series and found fusion was achieved in 98% of cases followed to commencement of surgery.
Abstract: Object. In this, the first of two articles regarding C1–2 transarticular screw fixation, the authors assessed the rate of fusion, surgery-related complications, and lessons learned after C1–2 transarticular screw fixation in an adult patient series. Methods. The authors retrospectively reviewed 191 consecutive patients (107 women and 84 men; mean age 49.7 years, range 17–90 years) in whom at least one C1–2 transarticular screw was placed. Overall 353 transarticular screws were placed for trauma (85 patients), rheumatoid arthritis (63 patients), congenital anomaly (26 patients), os odontoideum (four patients), neoplasm (eight patients), and chronic cervical instability (five patients). Among these, 67 transarticular screws were placed in 36 patients as part of an occipitocervical construct. Seventeen patients had undergone 24 posterior C1–2 fusion attempts prior to referral. The mean follow-up period was 15.2 months (range 0.1–106.3 months). Fusion was achieved in 98% of cases followed to commencement of f...
306 citations
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United States Department of Health and Human Services1, Hastings Center2, Veterans Health Administration3, Center for Humans and Nature4, National Quality Forum5, United States Department of Veterans Affairs6, American Medical Association7, Bowling Green State University8, National Committee for Quality Assurance9, Vanderbilt University10, Dartmouth College11, University of North Carolina at Chapel Hill12, Agency for Healthcare Research and Quality13, Yeshiva University14, Primary Children's Hospital15
TL;DR: This report discusses deliberate efforts of providers to meet their obligations to improve the quality of patient care through clinical and managerial changes in the processes of care, and presents recommendations for developing policy and practices to protect patients from both the harm that QI activities might cause and the harms that quality and safety deficits do cause.
Abstract: Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities designed to bring about immediate improvements in health care delivery in particular settings and concluded that QI is an intrinsic part of normal health care operations. Both clinicians and patients have an ethical responsibility to participate in QI, provided that it complies with specified ethical requirements. Most QI activities are not human subjects research and should not undergo review by an institutional review board; rather, appropriately calibrated supervision of QI activities should be part of professional supervision of clinical practice. The group formulated a framework that would use key characteristics of a project and its context to categorize it as QI, human subjects research, or both, with the potential of a customized institutional review board process for the overlap category. The group recommended a period of innovation and evaluation to refine the framework for ethical conduct of QI and to integrate that framework into clinical practice.
306 citations
Authors
Showing all 1777 results
Name | H-index | Papers | Citations |
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Scott Thomas | 131 | 1219 | 85507 |
Michael R. Bristow | 113 | 508 | 60747 |
Ikuo Ueda | 106 | 1053 | 48642 |
David Robinson | 101 | 757 | 38372 |
Pedram Argani | 97 | 372 | 35607 |
Glenn D. Prestwich | 88 | 690 | 42758 |
Melvin M. Scheinman | 86 | 531 | 25883 |
John M. Opitz | 85 | 1193 | 40257 |
George R. Saade | 82 | 872 | 30325 |
James Neil Weinstein | 81 | 325 | 24918 |
Michael Charlton | 79 | 333 | 28494 |
James M. Ford | 79 | 314 | 20750 |
Michael W. Varner | 74 | 405 | 19346 |
Murray D. Mitchell | 74 | 540 | 20408 |
Jeffrey L. Anderson | 73 | 300 | 25916 |