Primary Children's Hospital

About: Primary Children's Hospital is a healthcare organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Health care. The organization has 1770 authors who have published 2594 publications receiving 107857 citations. The organization is also known as: Intermountain Primary Children's Medical Center & Intermountain Primary Children's Hospital.

Maternal depressed mood and stress as related to vigilance, self-efficacy and mother-child interactions

Abstract: Parenting self-efficacy, maternal vigilance, competence and child behaviour were studied in a community sample of mothers of 18-36-month-old children. Thirty dysphoric mothers had elevated Beck Depression Inventory (BDI) scores (12–16) and 30 nondysphoric mothers had BDIs <5. Dysphoric mothers were more stressed, less happily married, less effective as parents and described their children as less competent and responsive than did non-dysphoric mothers. When completing a distracting questionnaire task, all mothers were less vigilant and their children less well behaved than during free play. Stressed, dysphoric mothers were observed to be less sensitive, responsive, warm, vigilant and effective in controlling their children, and their children were more destructive, and less happy, responsive and compliant. Combined maternal stress and dysphoria were associated with generally negative perceptions of self and child, and negative mother-child interactions.

Longitudinal observation of pediatric hand and wrist ganglia

Abstract: The purpose of this study was to examine the behavior of ganglia of the hand and wrist in young children treated without surgery. Fourteen consecutive children, less than 10 years of age, who presented with cysts of the hand and wrist were followed up by a single surgeon. The average age of the patient at the time of diagnosis was 38 months (range, 2 months to 9 years 3 months). The masses included 7 retinacular cysts, 5 volar wrist ganglia, and 2 dorsal wrist ganglia. These cysts had been present for an average of 3.3 months (range, 1-12 months) before medical advice was sought. None of the cysts were painful. Follow-up averaged 33 months (range, 9-112 months), with 79% of all cysts spontaneously resolving, the majority within a year. We believe that a child presenting with a benign hand lesion characteristic of a ganglion cyst should initially be treated by observation.

Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunction.

Abstract: The use of β-blocking agents in adults with congestive heart failure has been shown to improve symptoms and outcome; however, experience in pediatric patients with left ventricular systolic dysfunction is limited. We identified 12 pediatric patients treated with β-blocking agents for left ventricular systolic dysfunction and reviewed echocardiographic indices of left ventricular systolic performance prior to initiation of β-blocker therapy and at intermediate follow-up. Left ventricular fractional shortening and ejection fraction increased significantly from baseline to intermediate follow-up (13 ± 4% to 21 ± 8% [p = 0.01] and 26 ± 8% to 41 ± 17% [p = 0.04], respectively). When added to conventional therapy, β-blocker therapy resulted in an increase in ejection-phase indices of left ventricular systolic performance at intermediate follow-up in pediatric patients with systolic dysfunction.

Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee

Abstract: BACKGROUND The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy of novel agents. Herein, the authors report the response rate to the combination of vincristine (V) and irinotecan (I) and the outcome of patients with high-risk hepatoblastoma. METHODS Patients with newly diagnosed metastatic hepatoblastoma or those with a serum α-fetoprotein (AFP) level 1 log10) decline in their AFP level. Responders were to receive 2 additional cycles of VI intermixed with 6 cycles of the combination of cisplatin, doxorubicin, 5-fluorouracil, and vincristine (C5VD). Nonresponders were to receive 6 cycles of C5VD alone. RESULTS A total of 32 patients with a median age at diagnosis of 26 months (range, 11-159 months) were enrolled between September 2009 and February 2012. Fourteen of 30 evaluable patients were responders (RECIST and AFP in 6 patients, RECIST only in 3 patients, and AFP only in 5 patients). The median AFP decline after 2 cycles of VI for the entire group was 345,565 ng/mL (85% of the initial AFP). The 3-year event-free and overall survival rates were 49% (95% confidence interval, 30%-65%) and 62% (95% confidence interval, 42%-77%), respectively. CONCLUSIONS The VI combination appears to have substantial activity against HR hepatoblastoma. The ultimate impact of this regimen in improving the outcomes of children with HR hepatoblastoma remains to be determined. Cancer 2017;123:2360–2367. © 2017 American Cancer Society.