Primary Children's Hospital

About: Primary Children's Hospital is a healthcare organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Health care. The organization has 1770 authors who have published 2594 publications receiving 107857 citations. The organization is also known as: Intermountain Primary Children's Medical Center & Intermountain Primary Children's Hospital.

Factors associated with stroke following the Fontan procedure.

Abstract: We reviewed the results of 68 consecutive Fontan procedures from 1978 to 1993 to determine the frequency of late central neurologic complications of the Fontan procedure in patients living at a mean altitude of 4500 feet. Two surviving patients had transient neurologic symptoms or signs with no corresponding evidence of brain injury by magnetic resonance imaging (MRI), whereas six surviving patients had strokes defined by sustained neurologic symptoms or signs with areas of brain injury identified by MRI [8.8% (6.0–13.0%; 70% confidence limits)]. Collectively, patients with neurologic symptoms had normal hemoglobin values, platelet counts, partial thromboplastin times, and prothrombin times at the onset of clinical neurologic findings. Two patients were taking antiplatelet agents, and one patient was taking warfarin. One of the patient's with transient neurologic findings and all of the stroke patients had residual right-to-left shunts. Thus strokes were not uncommon in our patients after the Fontan procedure. Brain injury may result. from thromboembolic events associated with residual right-to-left shunts, but our total number of asymptomatic patients with a residual shunt or brain abnormalities by MRI is not known.

Sumatriptan in the treatment of cyclic vomiting

Abstract: Objective:To describe a patient with cyclic vomiting who was treated successfully with sumatriptan, a serotonin, agonist.Case Summary:A patient with a 4-year history of cyclic vomiting was treated for an episode of nausea, vomiting, and abdominal pain. This patient had been hospitalized numerous times for cyclic vomiting over the previous 4 years, each hospitalization lasting from 3 to 11 days. Following a single subcutaneous injection of sumatriptan 6 mg, the patient ceased vomiting and was discharged 40 hours from the time of admission.Discussion:The efficacy of sumatriptan in migraine headache appears to be mediated through its agonist activity at the serotonin1D receptor, resulting in constriction of dural blood vessels. According to published reports, therapeutic attempts at controlling cyclic vomiting often have included antimigraine therapies. Consistent with these reports, sumatriptan also appears effective in the treatment of cyclic vomiting.Conclusions:The pathogenesis of cyclic vomiting appears...

Influenza virus infection in infants less than three months of age.

Abstract: Objective:We evaluated the presentation, outcomes, and the risk of serious bacterial infection (SBI) in infants <3 months old with influenza virus infection.Patients and Methods:We identified demographic, hospitalization, and microbiologic data from computerized medical records for all infants and c

Evolving epidemiologic characteristics of invasive group a streptococcal disease in Utah, 2002-2010.

Abstract: Background. Invasive group A Streptococcus (GAS) infections are associated with substantial morbidity andmortality. Recent national surveillance data report stable rates of invasive GAS disease, although these may notcapture geographic variation.Methods. We performed a population-based, retrospective laboratory surveillance study of invasive GASdisease among Utah residents from 2002–2010. We used Intermountain Healthcare’s electronic medical recordsand data warehouse to identify patients from whom GAS was isolated by culture. We defined clinical syndromesof invasive GAS disease on the basis of International Classification of Diseases, Ninth Revision codes. We abstract-ed demographic information, comorbidities, and microbiologic and laboratory findings.Results. From 2002–2010, we identified 1514 cases of invasive GAS disease among Utah residents. The esti-mated mean annual incidence rate was 6.3 cases/100000 persons, which was higher than the national rate of 3.6cases/100000 (P<.01). The incidence of invasive GAS disease in Utah rose from 3.5 cases/100000 persons in2002 to 9.8 cases/100000 persons in 2010 (P=.01). Among children aged <18 years, the incidence of invasiveGAS increased from 3.0 cases/100000 children in 2002 to 14.1 cases/100000 children in 2010 (P<.01). The in-crease in the pediatric population was due, in part, to an increase in GAS pneumonia (P=.047). The rate ofinvasive GAS disease in adults aged 18–64 years increased from 3.4 cases/100000 persons in 2002 to 7.6 cases/100000 persons in 2010 (P=.02). Rates among those aged ≥65 years were stable. The incidence of acute rheumat-ic fever declined from 6.1 to 3.7 cases/100000 (P=.04).Conclusions. The epidemiologic characteristics of invasive GAS disease in Utah has changed substantiallyover the past decade, including a significant increase in the overall incidence of invasive disease—driven primarilyby increasing disease in younger persons—that coincided temporally with a decrease in the incidence of acuterheumatic fever.Infection by Streptococcus pyogenes (group A strepto-cocci [GAS]) causes a wide range of syndromes rangingfrom localized illness, such as pharyngitis, to invasivedisease, such as bacteremia, pneumonia, necrotizingfasciitis, and streptococcal toxic shock syndrome [1, 2].Invasive GAS infection causes significant morbidity andmortality in both children and adults [3].The epidemiologic characteristics of GAS diseaseare complex. An apparent increase in invasive GAS