Showing papers by "Scuola superiore di Catania published in 2020"

Bandwidth-Efficient Threshold EC-DSA

Abstract: Threshold Signatures allow n parties to share the power of issuing digital signatures so that any coalition of size at least t+1 can sign, whereas groups of t or less players cannot. Over the last few years many schemes addressed the question of realizing efficient threshold variants for the specific case of EC-DSA signatures. In this paper we present new solutions to the problem that aim at reducing the overall bandwidth consumption. Our main contribution is a new variant of the Gennaro and Goldfeder protocol from ACM CCS 2018 that avoids all the required range proofs, while retaining provable security against malicious adversaries in the dishonest majority setting. Our experiments show that-for all levels of security-our signing protocol reduces the bandwidth consumption of best previously known secure protocols for factors varying between 4.4 and 9, while key generation is consistently two times less expensive. Furthermore compared to these same protocols, our signature generation is faster for 192-bits of security and beyond.

β-amyloid and oxidative stress: Perspectives in drug development

Abstract: Alzheimer's Disease (AD) is a slow-developing neurodegenerative disorder in which the main pathogenic role has been assigned to β-amyloid protein (Aβ) that accumulates in extracellular plaques. The mechanism of action of Aβ has been deeply analyzed and several membrane structures have been identified as potential mediators of its effect. The ability of Aβ to modify neuronal activity, receptor expression, signaling pathways, mitochondrial function, and involvement of glial cells have been analyzed. In addition, extensive literature deals with the involvement of oxidative stress in Aβ effects. Herein we focus more specifically on the reciprocal regulation of Aβ, that causes oxidative stress, that favors Aβ aggregation and toxicity and negatively affects the peptide clearance. Analysis of this strict interaction may offer novel opportunities for therapeutic intervention. Both common and new molecules endowed with antioxidant properties deserve attention in this regard.

Silicon nanowire luminescent sensor for cardiovascular risk in saliva

Abstract: Cardiovascular diseases are some of the today major cause of death in the world. C-reactive protein (CRP) is well known as the main biomarker related to cardiovascular risk and heart attack occurrence. The standard CRP analyses are performed in a hospital or in a biochemical laboratory with blood analysis after a long chemical and labelling preparation that require expert personnel. In this scenario, a health care analysis that can be performed by the same patient at his own home appears extremely revolutionary. In this paper, the study of an innovative sensing platform based on the luminescence at room temperature of silicon nanowires (NWs) is reported. This NWs sensor is label-free and does not require a chemical treatment of the analyte, is strongly selective to the CRP demonstrating a femtomolar limit of detection and a wide operating range. This proposed silicon sensing platform can be realized with an industrial compatible approach and permits to reveal the strategic CRP level in saliva in order to prevent a heart attack, with great advantages for the patient.

Low cost synthesis of silicon nanowires for photonic applications

Abstract: Achieving light management in nanostructured materials is a recent challenge of great resonance among the scientific community, which is generally attained by expensive surface patterning requiring advanced technologies. In this paper, we report the realization of 2D random fractal arrays of silicon nanowires (NWs) synthesized with a low cost approach compatible with Si technology, without the use of any lithography or mask. Their innovative photonic properties are exploited in comparison to non-fractal nanowires. In particular, a remarkable room temperature luminescence is attained in Si NWs due to quantum confinement effect. The NWs fabrication was engineered in order to produce two-dimensional random fractal arrays of Si NWs whose structural properties were investigated and compared to other non-fractal Si NW systems. The impressive light trapping and strongly enhanced Raman signal of our fractal Si NW array is of significant interest for potential applications spanning from photonics, to photovoltaics and sensing.

Interacting Discovery Processes on Complex Networks.

Abstract: Innovation is the driving force of human progress. Recent urn models reproduce well the dynamics through which the discovery of a novelty may trigger further ones, in an expanding space of opportunities, but neglect the effects of social interactions. Here we focus on the mechanisms of collective exploration, and we propose a model in which many urns, representing different explorers, are coupled through the links of a social network and exploit opportunities coming from their contacts. We study different network structures showing, both analytically and numerically, that the pace of discovery of an explorer depends on its centrality in the social network. Our model sheds light on the role that social structures play in discovery processes.

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors.

Abstract: Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, evaluated by three anxiety-related paradigms in rats. First, we confirmed that acute treatment with GUO exerts an anxiolytic-like effect. Subsequently, we investigated the effects of pretreatment with ADO or A1R (CPA, CCPA) or A2AR (CGS21680) agonists 10 min prior to GUO on a GUO-induced anxiolytic-like effect. All the combined treatments blocked the GUO anxiolytic-like effect, whereas when administered alone, each compound was ineffective as compared to the control group. Interestingly, the pretreatment with nonselective antagonist caffeine or selective A1R (DPCPX) or A2AR (ZM241385) antagonists did not modify the GUO-induced anxiolytic-like effect. Finally, binding assay performed in hippocampal membranes showed that [3H]GUO binding became saturable at 100-300 nM, suggesting the existence of a putative GUO binding site. In competition experiments, ADO showed a potency order similar to GUO in displacing [3H]GUO binding, whereas AR selective agonists, CPA and CGS21680, partially displaced [3H]GUO binding, but the sum of the two effects was able to displace [3H]GUO binding to the same extent of ADO alone. Overall, our results strengthen previous data supporting GUO-mediated anxiolytic-like effects, add new evidence that these effects are blocked by A1R and A2AR agonists and pave, although they do not elucidate the mechanism of GUO and ADO receptor interaction, for a better characterization of GUO binding sites in ARs.

A characterization of the Arf property for quadratic quotients of the Rees algebra

Abstract: We provide a characterization of the Arf property in both the numerical duplication of a numerical semigroup and in a member of a family of quotients of the Rees algebra studied in [V. Barucci, M. ...

Graphene Oxide Nanosheets Tailored With Aromatic Dipeptide Nanoassemblies for a Tuneable Interaction With Cell Membranes.

Abstract: Engineered graphene-based derivatives are attractive and promising candidates for nanomedicine applications because of their versatility as 2D nanomaterials. However, the safe application of these materials needs to solve the still unanswered issue of graphene nanotoxicity. In this work, we investigated the self-assembly of dityrosine peptides driven by graphene oxide (GO) and/or copper ions in the comparison with the more hydrophobic diphenylalanine dipeptide. To scrutinize the peptide aggregation process, in the absence or presence of GO and/or Cu2+, we used atomic force microscopy, circular dichroism, UV-visible, fluorescence and electron paramagnetic resonance spectroscopies. The perturbative effect by the hybrid nanomaterials made of peptide-decorated GO nanosheets on model cell membranes of supported lipid bilayers was investigated. In particular, quartz crystal microbalance with dissipation monitoring and fluorescence recovery after photobleaching techniques were used to track the changes in the viscoelastic properties and fluidity of the cell membrane, respectively. Also, cellular experiments with two model tumour cell lines at a short time of incubation, evidenced the high potential of this approach to set up versatile nanoplatforms for nanomedicine and theranostic applications.

Patterns on the Numerical Duplication by Their Admissibility Degree

Abstract: We develop the theory of patterns on numerical semigroups in terms of the admissibility degree. We prove that the Arf pattern induces every strongly admissible pattern, and determine all patterns equivalent to the Arf pattern. We study patterns on the numerical duplication Open image in new window when d ≫ 0. We also provide a definition of patterns on rings.