Institution
Translational Research Institute
Facility•Woolloongabba, Queensland, Australia•
About: Translational Research Institute is a facility organization based out in Woolloongabba, Queensland, Australia. It is known for research contribution in the topics: Population & Cancer. The organization has 817 authors who have published 1163 publications receiving 25513 citations.
Topics: Population, Cancer, Kidney disease, Medicine, Dialysis
Papers published on a yearly basis
Papers
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TL;DR: Investigation of the effect of chlorpyrifos, a broad spectrum organophosphorus insecticides, on the expression of vitamin D3 receptor (VDR) in human keratinocytes cell line HaCaT and fibroblasts cell line BJ concluded that OPs pesticide might interfere with vitamin D 3 metabolism in skin cells.
3 citations
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TL;DR: This hypothesis that activation of PAR2 in cultured tubular epithelial cells induces extracellular signal‐regulated kinase signalling and secretion of fibronectin, C–C Motif Chemokine Ligand 2 and transforming growth factor‐β1 is tested in unilateral ureteric obstruction.
Abstract: Aim: Protease-activated receptor 2 (PAR2) has been implicated in the development of renal inflammation and fibrosis. In particular, activation of PAR2 in cultured tubular epithelial cells induces extracellular signal-regulated kinase signalling and secretion of fibronectin, C–C Motif Chemokine Ligand 2 (CCL2) and transforming growth factor-β1 (TGF-β1), suggesting a role in tubulointerstitial inflammation and fibrosis. We tested this hypothesis in unilateral ureteric obstruction (UUO) in which ongoing tubular epithelial cell damage drives tubulointerstitial inflammation and fibrosis. Methods: Unilateral ureteric obstruction surgery was performed in groups (n = 9/10) of Par2−/− and wild type (WT) littermate mice which were killed 7 days later. Non-experimental mice were controls. Results: Wild type mice exhibited a 5-fold increase in Par2 messenger RNA (mRNA) levels in the UUO kidney. In situ hybridization localized Par2 mRNA expression to tubular epithelial cells in normal kidney, with a marked increase in Par2 mRNA expression by tubular cells, including damaged tubular cells, in WT UUO kidney. Tubular damage (tubular dilation, increased KIM-1 and decreased α-Klotho expression) and tubular signalling (extracellular signal-regulated kinase phosphorylation) seen in WT UUO were not altered in Par2−/− UUO. In addition, macrophage infiltration, up-regulation of M1 (NOS2) and M2 (CD206) macrophage markers, and up-regulation of pro-inflammatory molecules (tumour necrosis factor, CCL2, interleukin-36α) in WT UUO kidney were unchanged in Par2−/− UUO. Finally, the accumulation of α-SMA+ myofibroblasts, deposition of collagen IV and expression of pro-fibrotic factors (CTGF, TGF-β1) were not different between WT and Par2−/− UUO mice. Conclusion: Protease-activated receptor 2 expression is substantially up-regulated in tubular epithelial cells in the obstructed kidney, but this does not contribute to the development of tubular damage, renal inflammation or fibrosis.
3 citations
01 Jan 2016
TL;DR: The Colorado Richly Annotated Full-Text (CRAFT) Corpus, a collection of full-length, open-access biomedical journal articles that have been manually annotated both syntactically and semantically with select Open Biomedical Ontologies, is created, the first release of which includes 100,000 annotations of concepts mentioned in the text of 67 articles and mapped to the classes of eight prominent OBOs.
Abstract: Ontologies are increasingly used for semantic integration across disparate curated biomedical resources, while gold-standard annotated corpora are needed for accurate training and evaluation of text-mining tools. Bringing together the respective power of these, we created the Colorado Richly Annotated Full-Text (CRAFT) Corpus, a collection of full-length, open-access biomedical journal articles that have been manually annotated both syntactically and semantically with select Open Biomedical Ontologies (OBOs), the first release of which includes ~100,000 annotations of concepts mentioned in the text of 67 articles and mapped to the classes of eight prominent OBOs. Here we present our continuing work on the corpus, including updated versions of these annotations with newer versions of the ontologies, new annotations made with two additional OBOs, annotations made with newly created extension classes defined in terms of existing classes of the ontologies, and new annotations of roots of prefixed and suffixed words. Keywords—annotation, corpus, markup, ontology.
3 citations
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30 Jun 2019TL;DR: It is recommended that reporting clinical research should include sufficient information on study design and analysis plan that contains data processing, quality assurance, and appropriate methods used for rigorous statistical analysis or modeling.
Abstract: Transparency in reporting the results of clinical and preclinical research is critical for unbiased publications. Funding agencies, publishers, and regulators have the responsibility to advocate and implement reporting standards for rigorous design. While individual study protocols may have included these standards, the items reported in the respective publications have often been inconsistent or lack transparency. This editorial intends to provide some specific guidelines for reporting results of clinical research with standards required for rigorous study design. We recommend that reporting clinical research should include sufficient information on study design and analysis plan that contains data processing, quality assurance, and appropriate methods used for rigorous statistical analysis or modeling. Any discrepancy between publications and original study design should be disclosed and discussed. Additionally, recent advances in the analysis of outcome with repeated measurements and statistical modeling should be employed to obtain unbiased estimates. Finally, we briefly discuss some issues reporting real-world evidence in clinical research.
3 citations
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04 Aug 2021TL;DR: In this paper, the authors explored the technical feasibility of a 7T magnetic resonance scanner using an ECG trigger learning algorithm to quantitatively assess cardiac volumes and vascular flow, which was performed using a learning phase outside of the magnetic field, with a trigger algorithm overcoming severe ECG signal distortions.
Abstract: Objective: Ultra-high-field B0 ≥ 7 tesla (7T) cardiovascular magnetic resonance (CMR) offers increased resolution. However, electrocardiogram (ECG) gating is impacted by the magneto-hydrodynamic effect distorting the ECG trace. We explored the technical feasibility of a 7T magnetic resonance scanner using an ECG trigger learning algorithm to quantitatively assess cardiac volumes and vascular flow. Methods: 7T scans were performed on 10 healthy volunteers on a whole-body research MRI MR scanner (Siemens Healthineers, Erlangen, Germany) with 8 channel Tx/32 channels Rx cardiac coils (MRI Tools GmbH, Berlin, Germany). Vectorcardiogram ECG was performed using a learning phase outside of the magnetic field, with a trigger algorithm overcoming severe ECG signal distortions. Vectorcardiograms were quantitatively analyzed for false negative and false positive events. Cine CMR was performed after 3rd-order B0 shimming using a high-resolution breath-held ECG-retro-gated segmented spoiled gradient echo, and 2D phase contrast flow imaging. Artefacts were assessed using a semi-quantitative scale. Results: 7T CMR scans were acquired in all patients (100%) using the vectorcardiogram learning method. 3,142 R-waves were quantitatively analyzed, yielding sensitivity of 97.6% and specificity of 98.7%. Mean image quality score was 0.9, sufficient to quantitate both cardiac volumes, ejection fraction, and aortic and pulmonary blood flow. Mean left ventricular ejection fraction was 56.4%, right ventricular ejection fraction was 51.4%. Conclusion: Reliable cardiac ECG triggering is feasible in healthy volunteers at 7T utilizing a state-of-the-art three-lead trigger device despite signal distortion from the magnetohydrodynamic effect. This provides sufficient image quality for quantitative analysis. Other ultra-high-field imaging applications such as human brain functional MRI with physiologic noise correction may benefit from this method of ECG triggering.
3 citations
Authors
Showing all 830 results
Name | H-index | Papers | Citations |
---|---|---|---|
David W. Johnson | 160 | 2714 | 140778 |
Peter M. Visscher | 143 | 694 | 118115 |
Jian Yang | 142 | 1818 | 111166 |
David A. Hume | 113 | 573 | 59932 |
David J. Hill | 107 | 1364 | 57746 |
Matthew A. Brown | 103 | 748 | 59727 |
Claude B. Sirlin | 98 | 475 | 33456 |
Bret H. Goodpaster | 94 | 281 | 37874 |
Irene Litvan | 91 | 380 | 46029 |
Erik W. Thompson | 90 | 420 | 29715 |
Kenneth J. O'Byrne | 87 | 629 | 39193 |
Michael S. Roberts | 82 | 740 | 27754 |
Ross Arena | 81 | 671 | 39949 |
Anne M Johnson | 77 | 302 | 24780 |
Takayuki Asahara | 76 | 252 | 44827 |