Institution
Translational Research Institute
Facility•Woolloongabba, Queensland, Australia•
About: Translational Research Institute is a facility organization based out in Woolloongabba, Queensland, Australia. It is known for research contribution in the topics: Population & Cancer. The organization has 817 authors who have published 1163 publications receiving 25513 citations.
Topics: Population, Cancer, Kidney disease, Medicine, Dialysis
Papers published on a yearly basis
Papers
More filters
University of Queensland1, University of Melbourne2, Translational Research Institute3, Griffith University4, University of Louisville5, World Health Organization6, University of Western Australia7, University of London8, University of Leicester9, University Medical Center Groningen10, University of Bergen11, Norwegian Institute of Public Health12, University of Michigan13, University of Sydney14, University of Manchester15, Central Manchester University Hospitals NHS Foundation Trust16, Boston Children's Hospital17, University of Groningen18, Research Triangle Park19, University of Pretoria20, Karolinska Institutet21, University of Bristol22, University of Utah23, University of Cambridge24
TL;DR: The World Health Organization (WHO) application of the International Classification of Diseases for perinatal mortality (ICD‐PM) aims to improve data on stillbirth to enable prevention.
129 citations
TL;DR: In this paper, the authors summarize patients' perspectives of dietary and fluid management in chronic kidney disease to inform clinical practice and research, and suggest strategies to help patients adjust to dietary regimens in order to reduce their impact on quality of life.
129 citations
TL;DR: The results indicate that cardiotoxicity is a class effect, but the magnitude of the risk is widely variable between individual NSAID drugs.
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs with analgesic, anti-inflammatory, and antipyretic activity. Their effect is achieved by the reduction in synthesis of prostanoids. Inhibition of prostanoids is responsible for a substantial risk of adverse effects. The risk of side effects affecting the gastrointestinal tract and kidneys has long been known. The possibilities of blood pressure elevation and the development of congestive heart failure are also widely recognized. Increased incidence of acute myocardial infarction in clinical trials with rofecoxib drew attention to the potential cardiotoxicity of selective cyclooxygenase-2 inhibitors, and similarly, concerns have been raised regarding the cardiovascular safety of non-selective NSAIDs. The safety of NSAIDs with regards to cardiovascular events has been studied in recent years in a large number of retrospective and prospective clinical studies and meta-analyses. The results indicate that cardiotoxicity is a class effect, but the magnitude of the risk is widely variable between individual NSAID drugs. This article aims to summarize the available data on the risk of adverse cardiovascular events with NSAIDs, the clinical impact of these events and possible underlying mechanisms.
128 citations
TL;DR: The data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.
Abstract: Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was genotyped in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.
127 citations
TL;DR: None of the prospective studies show that measurements of HDL cholesterol subfractions improve the identification of persons at risk, and HDL2 and HDL3 cholesterol do not distinguish cardioprotective differences between HDL subclasses.
126 citations
Authors
Showing all 830 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David W. Johnson | 160 | 2714 | 140778 |
| Peter M. Visscher | 143 | 694 | 118115 |
| Jian Yang | 142 | 1818 | 111166 |
| David A. Hume | 113 | 573 | 59932 |
| David J. Hill | 107 | 1364 | 57746 |
| Matthew A. Brown | 103 | 748 | 59727 |
| Claude B. Sirlin | 98 | 475 | 33456 |
| Bret H. Goodpaster | 94 | 281 | 37874 |
| Irene Litvan | 91 | 380 | 46029 |
| Erik W. Thompson | 90 | 420 | 29715 |
| Kenneth J. O'Byrne | 87 | 629 | 39193 |
| Michael S. Roberts | 82 | 740 | 27754 |
| Ross Arena | 81 | 671 | 39949 |
| Anne M Johnson | 77 | 302 | 24780 |
| Takayuki Asahara | 76 | 252 | 44827 |